Economic Equality
Across the globe there are huge disparities in access to basic services such as healthcare, education, and economic resources, with the UN estimating over 98 million people live on less than $1.90 a day. It is vital for microbial research to identify those areas which actively maintain cycles of poverty and disparity. In recognising the interconnected nature of human financial systems and environmental health, microbial research can be a leader in working toward Economic Equality.
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Marine-inspired sunscreen ingredient made by E. coli
Researchers have engineered microbial “cell factories” to sustainably produce the UV-protective compound gadusol, which could eventually serve as a sunscreen ingredient and an antioxidant additive. Gadusol, found in the eggs of various fish and other marine organisms, helps protect against ultraviolet damage.
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NewsResearchers develop realistic ‘mock’ samples to speed cervical cancer test development
A team of bioengineers has developed a new way to create highly realistic “mock” patient samples that could help accelerate the development of faster, more accessible cervical cancer screening tests for low-resource settings.
NewsThe hunt for red: Chromatin-mediated upregulation of Monascus pigments in Talaromyces purpurogenus OUCMDZ-019 via disruption of Ash2
The industrial application of Monascus pigments has been hindered by three key bottlenecks: unstable yield, poor environmental stability, and the risk of contamination by citrinin. Researchers adopted an epigenetic derepression strategy to unlock the hidden biosynthetic potential of MPs in Talaromyces purpurogenus OUCMDZ-019.
NewsResearchers develop microalgae that photosynthetically produce and secrete biofuel precursors
A research group has developed cyanobacterial strains that produce free fatty acids (FFAs) and secrete them into the culture medium. FFAs are important precursor materials for sustainable aviation fuel and diesel fuel alternatives.
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No refrigeration needed for killer disease vaccine
Malaria kills more than half a million people every year, but a new vaccine is showing promise as it not only offers long-lasting strong protection but also inhibits transmission of malaria by mosquitos. The vaccine is predicted to be low cost and its cold-chain independence strongly enhances its deployability.
New reactor design produces renewable methane from carbon dioxide
A new reactor design efficiently converts carbon dioxide and renewable electricity into methane while scaling the system up by roughly an order of magnitude. It demonstrated that microbial electrosynthesis systems can be expanded beyond laboratory-scale devices while maintaining high energy efficiency and methane production rates.
Aging immune systems show reduced ability to clear tuberculosis during treatment
Immunosenescence increases susceptibility to infectious diseases like tuberculosis (TB) in older adults and hinder effective containment of Mycobacterium tuberculosis during therapeutic intervention.
Ten years on, the Nagoya Protocol on sharing genetic resources is still confusing scientists - so here’s some much-needed guidance
More than a decade after the Nagoya Protocol, which aims to fairly share the benefits of utilizing genetic resources, became law, scientists still face practical challenges and confusion. A new guide provides universally applicable frameworks for anyone working with biological resources.
Researchers develop next-generation CRISPR biocontainment technology for controlling microbial survival without DNA cleavage
Researchers have employed a CRISPR-dCas9-based base editing system capable of introducing precise nucleotide changes without inducing DNA double-strand breaks. The researchers targeted the start codons of essential genes and irreversibly disrupted their function, permanently blocking cell survival.
Anti-CRISPR stops the protein assembly line in bacteria
Bacteria fend off invading viruses with molecular scissors that slice up viral DNA, but viruses can fight back with a molecular trick that stops the scissors from ever being made. A viral “anti-CRISPR” protein sits on the ribosome and jams it as a CRISPR protein named Cas12 begins to form.
Global outbreaks may fuel violence against women — but most cases go unmeasured
Violence against women and girls may increase during infectious disease outbreaks — as economic strain, isolation and disrupted services reshape daily life — yet those impacts remain largely unmeasured, according to a new study.
Light without electricity? Glowing algae could make it possible
Researchers successfully turned on the “light switch” in algae and kept them lit up using simple chemical solutions. The finding opens the door for future technologies such as autonomous robots that can operate in dark environments and living sensors for water quality.
Death-defying protein found in tardigrades preserves synthetic cells
Researchers have shown how a tardigrade protein protects cell membranes, using the proteins to preserve synthetic cells that were dried out and rehydrated in the lab. The finding could lead to a way to store and transport “microfactories” for producing medicines and other biological products.
With large DNA fragment assembly, scientists can design microbes that produce countless complex products
A review demonstrates that scientists can now reliably build and combine very large pieces of DNA, making it much easier to redesign microbes such as yeast and bacteria to act as efficient “cell factories.”
Scientists highlight the cost of delaying childhood vaccination
Delaying hepatitis B vaccination after birth increases infections among newborns and decreases their survival rates and quality of life. A new study found that the longer the delay, the higher the cost in human life and health care.
A universal toolkit for editing bacterial DNA
A major collaboration involving nine labs has transferred a particularly useful DNA editing system from E. coli into 14 new species of bacteria, spanning three major branches of the bacterial family tree.
How AI can help us count the ‘good’ viruses used in biopharmaceuticals
Researchers have developed a new methodology that uses artificial intelligence (AI) tools to identify and count target viruses more efficiently than previous techniques. The new approach can be used in applications such as pharmaceutical biomanufacturing.
Cosmetics from waste? New microbial discovery could enable more sustainable production of high-value chemical products
Researchers have made a key discovery about how certain bacterial strains produce a set of economically valuable chemicals — opening the door to new, more sustainable production methods. A family of molecules could be made via bacterial fermentation instead of from palm oil, as they are today.
World-first shoe made entirely from pure mycelium unveiled at Milan Design Week
A prototype shoe made entirely from pure mycelium, the root-like network of fungi, will debut at Milan Design Week. The project is a collaboration between researcher and designer Lars Dittrich of Vrije Universiteit Brussel and head shoemaker Marie De Ryck at La Monnaie/De Munt.
Severe childhood malaria linked to cognitive impairment later in life
New findings suggest children who survive cases of cerebral malaria and severe malarial anemia experience cognitive and academic impairment that persists into adolescence.
WHO-recommended antibiotics cover only 1 in 4 neonatal sepsis infections in low- and middle-income countries
A major multi-country study has found that WHO-recommended first-line antibiotics for neonatal sepsis are likely to be effective in only one quarter of infections in low- and middle-income countries (LMICs).
Engineered dual-bacterial sensors turn chemical signals into electricity
Most bacterial information transmission is done via electricity. While electricity-emitting bacteria exist, manipulating them into useful sensors has been quite challenging. Researchers recently developed a flexible bioelectrical sensor system called electroactive co-culture sensing system.
Researchers uncover a ‘treasure trove’ of bioactive molecules in coral reefs
Researchers have found that coral reefs are home to a vast array of previously unknown bioactive metabolites — small biomolecules that have the biotechnological potential to provide the basis for new drugs, and a host of other products.