The National Institutes of Health recently awarded the University of Kansas $5.8 million for Phase 3 of KU’s Chemical Biology of Infectious Disease center, an NIH Center of Biomedical Research Excellence (COBRE) that was established in 2016. The center recruits, mentors and supports investigators across KU, KU Medical Center, Kansas State, Wichita State and other regional partners as they address urgent challenges in infectious disease and antibiotic resistance using chemical-biology approaches. A Phase 3 award is intended to help a research center along a sustainable path beyond COBRE support at the federal level.
Until now, no one has observed a human gene that is both mobile and required for bodily functions. Scientists have found a human genetic element in a poxvirus and discovered it was both an important gene for brain function and a jumping gene capable of moving and inserting itself in genomes.
A polyphenol-rich extract from Cistus salviifolius demonstrated fungicidal activity against several dermatophytes and decreased fungal infection in a laboratory model of human epidermis.
A new tool to mutate bacteriophages – viruses that infect bacteria – provides a big leap forward in both our understanding of how they function, and our ability to harness their full potential. The new method allows for genome-wide mutagenesis of bacteriophages using CRISPR-Cas technology.
Before the parasite Toxoplasma gondii can invade a cell, it has to know it has reached the right place. New research from the Whitehead Institute reveals that the parasite doesn’t simply recognize a ready-made doorway into the cell. Instead, it helps create the conditions for its own entry.
Researchers have created an inexpensive, quick and accurate handheld device that can detect seven mosquito-borne illnesses. Their design could help clinicians in low-resource or remote settings — from clinics in rural Haiti to farm animal veterinarians — diagnose patients without the need for a power supply, bulky equipment or extensive training.
Until now, no one has observed a human gene that is both mobile and required for bodily functions. Scientists have found a human genetic element in a poxvirus and discovered it was both an important gene for brain function and a jumping gene capable of moving and inserting itself in genomes.
Scientists have often thought of cells as small bustling cities with parts that resemble factories, power grids, and shipping systems. Past research hasn’t had the tools to probe more deeply into how those different components interact, but researchers have now deployed cryo-electron tomography to visualise how different cellular processes are connected.
Researchers characterized changes in brain microRNAs during Powassan virus infection. MicroRNAs are tiny, natural molecules that help regulate how cells function by controlling protein production. The researchers found that these important regulators were widely disrupted as the infection progressed.
Scientists develop a database of validated guide RNAs to improve engineering of microbes for manufacturing applications.
A new recyclable system uses baker’s yeast to store H₂ in organic molecules and iron ions to release it when needed - offering a promising route toward more sustainable hydrogen production and storage.
Scientists have engineered yeasts that can simultaneously use different sugars in biomass crops.
A new tool to mutate bacteriophages – viruses that infect bacteria – provides a big leap forward in both our understanding of how they function, and our ability to harness their full potential. The new method allows for genome-wide mutagenesis of bacteriophages using CRISPR-Cas technology.
Researchers have created an inexpensive, quick and accurate handheld device that can detect seven mosquito-borne illnesses. Their design could help clinicians in low-resource or remote settings — from clinics in rural Haiti to farm animal veterinarians — diagnose patients without the need for a power supply, bulky equipment or extensive training.
This technology enables the direct rescue of segmented negative-sense RNA viruses from complementary DNA in monkey kidney Vero cells, facilitating safer and more efficient live-attenuated vaccine production.
The Food and Agriculture Organization of the United Nations is redesignating Mississippi State University as an FAO Reference Centre on Antimicrobial Resistance and Aquaculture Biosecurity.
A new clinical trial is recruiting people diagnosed with anorexia nervosa as researchers hope to discover if fecal microbiota transplant (FMT) capsules could help better manage this eating disorder.
Scientists are investigating how fungi can be harnessed to transform demolished concrete into reliable, high-value materials for future infrastructure.