One health

Communicable diseases remain one of the major causes of mortality worldwide. There are disparities in the numbers of individuals affected by disease between low-and-middle-income countries and those in developed nations. Microbes will play in important role in drug discovery: producing anticancer drugs and antimicrobials. Applying One Health principles, to understand the interaction of pathogens and the human host, development of diagnostics, treatments, and disease prevention, applied microbiologists can shape global health and wellbeing outcomes.

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Antibiotics could trigger immune response through gut microbiome metabolites

Researchers report how one of the most abundant gut bacteria responds to tetracyclines, a class of commonly prescribed antibiotics. Newly characterized signals released by the bacterium could aid the host’s immune response, inhibit pathogens and restructure the gut microbiome.

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Common water pill may help HIV medicines work faster and reduce inflammation, early study suggests

Adding a readily available diuretic to standard HIV therapy appears to reduce circulating virus by four-fold, a new study shows. Researchers treated HIV-infected mice with human immune cells with first‑line antiretroviral therapy plus a long‑acting form of spironolactone.