One health
Communicable diseases remain one of the major causes of mortality worldwide. There are disparities in the numbers of individuals affected by disease between low-and-middle-income countries and those in developed nations. Microbes will play in important role in drug discovery: producing anticancer drugs and antimicrobials. Applying One Health principles, to understand the interaction of pathogens and the human host, development of diagnostics, treatments, and disease prevention, applied microbiologists can shape global health and wellbeing outcomes.
News
Gut microbes rewrite the rules of cancer immunotherapy
A review synthesizes growing evidence showing that commensal microbes enhance anti-tumor immunity by producing immune-active metabolites, remodeling the tumor microenvironment, and activating key immune cells such as dendritic cells and cytotoxic T cells.
Read story
NewsMicrobe exposure may not protect against developing allergic disease
The “hygiene hypothesis” suggests exposure to diverse types of microbes may protect against developing diseases caused by allergens, but a new study in mice reveals that adults’ exposure to diverse microbes and allergens may in fact worsen certain allergic conditions.
NewsNew studies reveal how Clostridioides difficile behaves inside the body
Researchers studying C. diff at multiple levels, from how individual bacterial cells behave inside the gut to the molecular switches that help them survive and spread, are revealing hidden vulnerabilities.
NewsHerpes virus fluidizes cell nuclei to multiply faster
A new study finds that herpes simplex virus uses a protein called infected cell protein 4 (ICP4) to make the human nucleus more fluid-like, which in turn makes it easier for the virus to replicate itself. Blocking the ability of ICP4 to fluidize the nuclear compartment caused a drop in viral copy production.
More One Health
News
How viruses mess with our brains
What impact does a viral infection have on our memory, attention, and concentration? A new review has identified several biological markers associated with cognitive decline in the context of infection. It also provides a solid foundation for future research.
NewsOne Health antimicrobial resistance modelling: from science to policy
Researchers have identified fundamental gaps in current mathematical modelling approaches that prevent translation of science into policy, including data limitations, knowledge gaps about AMU-AMR relationships, and the absence of international coordination mechanisms similar to climate change efforts.
NewsNew compound stops common complications after intestinal surgery
Researchers have synthesized and tested a new compound in mice that shows promise in protecting the liver from damage and improving nutrient absorption after small bowel resection. They also found that the drug works only on the gastrointestinal tract.
NewsScientists engineer ‘living eye drop’ to support corneal healing
A proof-of-concept study demonstrates that the harmless eye-dwelling microbe Corynebacterium mastitidis can be genetically modified to secrete an anti-inflammatory therapeutic that promotes healing following corneal injury in a mouse model.
News Natural dye produced by Amazonian fungus can be used in cosmetics
A red extract made from Talaromyces amestolkiae was tested in the bases of potential products, including face cream, shampoo, and gel sticks, for its antioxidant and antibacterial properties.
NewsStudy reveals how gut bacteria and diet can reprogram fat to burn more energy
A new study shows that a low‑protein diet activates a precise set of gut microbes that send chemical signals throughout the body, prompting fat tissue to burn energy instead of storing it. The findings uncover a previously unknown biological pathway linking diet, the gut microbiome and metabolic health.
NewsStudy warns of underrecognized Lassa Fever threat with global implications
A new study shows an urgent need for improved detection and treatment of Lassa fever. The study in Liberia found a high prevalence of Lassa fever among febrile admissions: 11% of patients with fever had Lassa fever despite not being suspected clinically.
NewsFrom gut to lung: A microbial signal that strengthens early immune defense
Researchers report that a gut microbiota–derived metabolite can directly shape immune responses in bacterial pneumonia. Using a Klebsiella pneumoniae infection model, the team demonstrated that butyric acid restores the function of CX3CR1-positive natural killer cells.
NewsHow periodontitis-linked bacteria accelerate osteoporosis-like bone loss through the gut
Researchers reveal that salivary bacteria from gum disease alter gut metabolism, driving osteoclast activity and systemic bone loss. They analyzed salivary microbiota from individuals with advanced periodontitis and compared them with samples from periodontally healthy donors.
NewsGut microbiome connected with heart disease precursor
Before the onset of cardiovascular disease symptoms, people often develop dyslipidemia, or abnormal levels of lipids in the blood. Microbiologists have identified microbial taxa more likely to be found in people with dyslipidemia than in people with healthy levels of cholesterol and triglycerides.
NewsAntibacterial coatings with short-term effect may fail over longer periods of time
Researchers have shown that antibacterial coatings which initially appear highly effective at destroying bacteria may lose their performance over time. Therefore, long-term testing is essential for developing the best antibacterial materials.
NewsTargeting the gut–lung microbiome to reduce infections in severe pancreatitis
Researchers report new clinical evidence that a fungal probiotic may reduce hospital-acquired infections in patients with severe acute pancreatitis. Patients receiving Saccharomyces boulardii alongside standard enteral nutrition experienced significantly fewer infections than those receiving nutrition alone.
NewsResearchers identify ‘neuroimmune signature’ that can predict viral hepatitis complications
A network of genes linked to the nervous and immune systems can predict cancer risk and even explain symptoms such as fatigue and depression resulting from viral hepatitis infection.
NewsScientists develop shape-shifting scaffold that fights infection and rebuilds bone
Scientists have developed a body-temperature–responsive, 3D-printed shape-memory scaffold coated with a metal–polyphenol network to treat infectious bone defects. It is designed to adapt to irregular bone defects while providing antibacterial activity, immune regulation, and osteogenic support.
News Thermo Fisher Scientific launches new color-based culture media to help detect Candida infections faster
Thermo Fisher Scientific today announced the launch of Thermo Scientific™ Brilliance™ Candida 2 Agar and Spectra™ Candida Agar, new color-based (chromogenic) culture media to help laboratories quickly detect and differentiate clinically important Candida species.
NewsBacteria found in mouth and gut may help protect against severe peanut allergic reactions
One of the big mysteries in food allergy is why two people with similar levels of peanut specific antibodies can react so differently. A new study shows for the first time how gut bacteria break down parts of an allergenic food and influence how a person reacts to peanuts.
NewsStudy finds natural fungal supplement improves COVID-19 vaccine response
Researchers have found that a natural fungal supplement taken at the time of COVID-19 vaccination reduced short-term vaccine side effects and helped antibodies last longer in people who had not previously been exposed to the virus.
NewsNew tool reveals the secrets of HIV-infected cells
Scientists have developed a novel tool—named HIV-seq—for profiling the features of rare HIV-infected cells from people with HIV. Using the new tool, they’ve found key differences in people’s HIV-infected cells before versus after starting antiretroviral therapy.
NewsChemically ‘stapled’ peptides used to target difficult-to-treat cancers
Researchers have developed a new technology that uses bacteria to build, chemically stabilise, and test millions of potential drug molecules inside living cells. The bacteria produce vast libraries of peptide molecules, and chemically stabilise them into defined shapes while they are being tested inside the cell.