One health
Communicable diseases remain one of the major causes of mortality worldwide. There are disparities in the numbers of individuals affected by disease between low-and-middle-income countries and those in developed nations. Microbes will play in important role in drug discovery: producing anticancer drugs and antimicrobials. Applying One Health principles, to understand the interaction of pathogens and the human host, development of diagnostics, treatments, and disease prevention, applied microbiologists can shape global health and wellbeing outcomes.
News
How a single viral protein hijacks immune cells to supercharge COVID-19 infection
A new discovery reveals how a SARS-CoV-2 protein reprograms immune cells to accelerate viral spread—and points to a new strategy for therapeutic intervention.
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NewsBoosted BCG vaccine strategy significantly reduces tuberculosis relapse
A new study reveals that combining an immunotherapy with the traditional Bacille Calmette-Guérin (BCG) vaccine drastically lowers the risk of TB relapse in preclinical models.
NewsA tiny bacterium with a huge impact
Researchers have discovered that gut bacteria and the compounds they produce trigger biological processes that the human body on its own can only activate with difficulty. They help suppress inflammation and may also have beneficial effects on fatty liver disease.
NewsNew study uncovers how the malaria parasite boosts its transmission potential under stress conditions
Researchers reveal the molecular mechanism by which Plasmodium falciparum responds to stress by increasing the production of the sexual forms required for transmission.
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News
New study uncovers the complex history of the plague after the Black Death
A new study sheds fresh light on the long and complex history of the plague by analysing the DNA of the bacterium. Researchers reconstructed 26 genomes of Yersinia pestis from archaeological sites in Estonia, Russia, England, the Netherlands, and Switzerland.
NewsA classic metabolic enzyme reveals a hidden role in broad-spectrum antiviral defense
Researchers find that the phosphoglycerate kinase 1 (PGK1) uses its non-canonical protein kinase activity to disrupt a host chaperone required by multiple viruses, suggesting a potential strategy for host-directed antiviral therapy.
NewsVaccination: why don’t we all experience the same side effects?
Researchers have found that, even before vaccination, some people’s innate immune systems are more reactive than others, showing a heightened response to interferons. The stronger this response, the more likely individuals are to experience these transient symptoms.
NewsOral chiral nanozyme protects the heart during chemotherapy by reshaping the gut-heart axis
A chirality-engineered nanozyme restores gut microbiota and host metabolism to prevent doxorubicin-induced cardiotoxicity without compromising anticancer efficacy.
NewsGlobal Virus Network comments on H5N1 detections in Australian mammals
The Global Virus Network (GVN) is closely monitoring detections of highly pathogenic avian influenza A (H5N1), commonly known as bird flu, in several mammal species in Australia as the virus continues to spread among birds and mammals worldwide.
NewsNew sepsis guidelines seek to reduce infection’s deadly toll
Experts have developed important new guidelines to improve care for patients who develop sepsis, a dangerous full-body infection that kills at least 350,000 Americans every year.
NewsLong-acting antibodies may work with the immune system to control HIV and help reduce the reservoir
Results from a clinical trial have offered a new HIV strategy, suggesting that just one or two doses of broadly neutralizing antibodies (bNAbs) can suppress the virus long-term, keeping it at undetectable levels for months and even years.
NewsUS officials suppressed warnings over flawed covid vaccine safety algorithm
US health officials knowingly relied on a compromised algorithm to detect signals of harm from mRNA covid-19 vaccines and silenced efforts to fix it, finds an investigation.
NewsTwo coronavirus master keys: new study unveils the mechanisms Covid-19 virus uses to enter our cells
To enter our cells, the Covid-19 virus fuses its surrounding membrane with the membrane of the target cell. The fusion peptides of the spike protein function as molecular keys that allow the virus to open the door to the target cell . A new study shows that SARS-CoV-2 does not have just one key, but two.
NewsNew test could dramatically speed diagnosis of hard-to-detect lung infections
Nontuberculous mycobacteria can cause chronic, tuberculosis-like lung infections. Researchers have developed a new diagnostic platform that can identify the precise species of bacteria causing a patient’s infection in just a few hours — a dramatic improvement over the current standard, which can take four to six weeks.
NewsNew method reveals how virus particles can build themselves, molecule by molecule
Researchers have captured the step-by-step assembly of individual virus-like particles, revealing how simple molecular interactions can reliably build these complex biological structures. The process works rather like finding a route through a maze in which only the productive turns lock into place.
NewsYour gut makes a molecule that fights a leading cause of food poisoning
Researchers have discovered that a molecule called indole can inhibit the growth of Campylobacter jejuni, a leading cause of food poisoning worldwide. Their study builds on years of research aimed at understanding how C. jejuni manages to thrive in the gut and cause disease.
NewsDeleting yeast DNA to save lives
People with weakened immune systems and some other conditions can experience an overgrowth of Candida yeasts, leading to a type of infection known as candidiasis. It might be possible to save these patients by using CRISPR to delete the very genes that let infectious Candida resist treatment - but which genes are responsible?
NewsWas Nîmes depopulated by the Plague of Cyprian?
Analyses of the carbonate deposits in the aqueduct featuring the famous Pont du Gard shed light on the water supply of the ancient city of Nîmes - and support the theory that the city was depopulated by the plague.
NewsGut microbiome features predict devastating disease affecting preemies
In a discovery that challenges long-standing assumptions about necrotizing enterocolitis, researchers have identified previously unknown predictors for the disease. They found that bacteria-infecting viruses and bacterial antibiotic resistance genes in the gut microbiomes of babies are additional harbingers of necrotizing enterocolitis.
NewsAn IBEC device simulates natural conditions to grow biofilms and test their antibiotic susceptibility more accurately
Researchers have developed XpertBiofilm, a simple and accessible device that allows biofilms to be grown under continuous, controlled liquid flow, similar to what bacteria encounter in the human body — for example, in lung mucus, blood or urine.
NewsWhat you need to know about rabies after recent North Carolina cases
In late August, the North Carolina Department of Health and Human Services confirmed multiple rabies cases in baby goats at a mobile petting zoo based in Iredell County. Hundreds of people may have been exposed to rabies from the goats when the zoo visited various locations over a five-week period.
NewsFirst-of-its-kind preventative phage therapy provides promising results
The mammalian gut microbiome is teeming with a delicate balance of bacteria and the phages that keep them in check. What if the phages in the gut could prepare for an orally ingested pathogen and strike it down as it enters the gut, negating the need for a battle?
NewsStudy supports effectiveness of RSV preventive antibody treatments for infants and provides new way to monitor viral resistance
An analysis of more than 60,000 respiratory syncytial virus (RSV) sequences from around the world found that viral variants associated with resistance to current RSV prevention tools remain rare, according to a study.