One health
Communicable diseases remain one of the major causes of mortality worldwide. There are disparities in the numbers of individuals affected by disease between low-and-middle-income countries and those in developed nations. Microbes will play in important role in drug discovery: producing anticancer drugs and antimicrobials. Applying One Health principles, to understand the interaction of pathogens and the human host, development of diagnostics, treatments, and disease prevention, applied microbiologists can shape global health and wellbeing outcomes.
News
Maternal antibodies in breast milk regulate early immune responses in mouse gut
In mice, maternal antibodies ingested in breast milk in the first week after birth help to regulate immune responses in the newborn gut, according to a new study.
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NewsArchaea can kill bacteria with new antibacterials
A first look into the molecular defenses of archaea highlights the importance of surveying diverse microbes to discover new types of antimicrobials.
News1 in 3 US adults unaware of connection between HPV and cancers
The human papillomavirus (HPV) can cause six types of cancer, yet new analysis shows that most people are unaware of the connection between HPV and all of these cancers.
NewsResearchers use generative AI to design compounds that can kill drug-resistant bacteria
With help from artificial intelligence, researchers have designed novel antibiotics that can combat two hard-to-treat infections: drug-resistant Neisseria gonorrhoeae and multi-drug-resistant Staphylococcus aureus (MRSA).
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News
A microbial DNA signature differentiates two types of cancer in the liver
Researchers have identified a microbial DNA signature in blood plasma that reliably differentiates primary liver cancer from colorectal cancer that has spread to the liver (metastatic colorectal cancer).
NewsStudy finds tiny microbes shape brain development
New research finds that microbes play an important role in shaping early brain development, specifically in a key brain region that controls stress, social behavior, and vital body functions.
News‘Essentiality’ scan reveals microbe’s ‘must-have’ list
Researchers have spent years taking apart one of the world’s simplest microbes, Mycoplasma pneumoniae, piece by piece, and created a detailed list of what molecular parts the living cell can and cannot do without.
NewsOne universal antiviral to rule them all?
Taking inspiration from a rare mutation that makes people impervious to viral diseases, a researcher is developing a therapy that could bestow this superpower on the rest of us. The mutation causes a deficiency in an immune regulator called ISG15.
News CRISPR-based therapeutics hold potential to combat AMR and cure chronic viral infections, says GlobalData
CRISPR-based therapeutics show potential to combat antimicrobial resistance (AMR) and deliver functional cures for chronic viral infections, says GlobalData, a leading data and analytics company.
NewsMount Sinai creates first manual for treating infection-associated chronic illness for clinicians
Mount Sinai has launched the country’s first clinical manual for treating infection-associated chronic illnesses (IACIs). This comprehensive guide, prepared by the Cohen Center for Recovery From Complex Chronic Illnesses, part of the Department of Rehabilitation and Human Performance, will help clinicians better diagnose and care for patients with conditions such ...
News‘Controlled evolution’ dramatically boosts pDNA production for biomedical manufacturing
Researchers have controlled the evolution of E. coli bacteria in the lab in order to dramatically increase the amount of plasmid DNA (pDNA) these modified bacteria produce. pDNA is an essential – and expensive – ingredient in many gene therapies.
NewsFlu fighters: researchers take a closer look at immune response to influenza
Researchers sought to identify which immune cells in pigs have receptors that are most reactive to influenza. They accomplished this by customizing a technology called single-cell RNA sequencing for pigs to learn more about how a body’s cells operate at a highly detailed level.
NewsBroad COVID-19 vaccination makes economic sense, especially for older adults, study finds
Vaccinating every person over 65 would actually save the U.S. money, while vaccinating all younger adults would be a reasonable investment, according to a new study.
NewsTwo-dose therapy for S. aureus bloodstream infections on par with standard treatment
A clinical trial has found that the outcome of treating complicated Staphylococcus aureus bloodstream infections with two intravenous (IV) doses of the antibiotic dalbavancin seven days apart is just as good as daily IV doses of conventional antibiotics over four to six weeks.
NewsBacterial protein therapy shows promise as first-ever antidote for carbon monoxide poisoning
Researchers have engineered a new molecule that appears promising as an effective antidote for carbon monoxide poisoning with fewer side effects than other molecules currently being tested.
NewsScientists find a microbial molecule that restores liver and gut health
Researchers have discovered that a natural molecule made by gut bacteria can reverse liver damage and repair the gut lining after aflatoxin exposure. The treatment may offer a new, non-toxic way to prevent and treat non-alcoholic fatty liver disease (NAFLD).
NewsLaser therapy enhances treatment of fungus resistant to conventional medication
Researchers have managed to reduce Candida albicans’ resistance to fungicides by incorporating photodynamic inactivation techniques into the treatment. The technology can be used in both human healthcare and the prevention of food contamination.
NewsStudy looks for markers that predict risk of severe chlamydia infection
A new study has identified markers that may predict whether a chlamydia infection is likely to ascend into the uterus and endometrium. The work could lead to new diagnostics that can predict a woman’s risk of severe infection.
NewsLignin is effective against viruses and bacteria
Lignin, a polyphenol, has antimicrobial activity against viruses and bacteria. An by-product from wood industry, lignin has potential as promising green alternative to synthetic antimicrobial agents for coating agents, packaging material, or surface disinfectants.
NewsAs school returns, so do infections & asthma emergencies. Where kids live can make it worse
A new study highlights how neighborhood conditions shape the seasonal surge of virus-triggered asthma emergencies. It found that children in under-resourced communities face sharply higher rates of asthma flare-ups tied to viral infections during the first weeks of school.
NewsFast, accurate, low-cost diagnostics - and no lab required
Researchers have developed a breakthrough diagnostic tool that could transform how quickly and reliably we detect illnesses like COVID-19, Ebola, AIDS or Lyme disease. The test uses just a single drop of blood, costs a couple of dollars and delivers results in only 15 minutes.
NewsSeventy-year-old Parkinson’s drug shows promise against tuberculosis
A medication developed in the 1950s to treat Parkinson’s disease may offer a powerful new tool in the fight against tuberculosis. The study found that benztropine can dramatically reduce levels of TB-causing bacteria by boosting the body’s natural immune response.
NewsScientists trace the evolution of the H5N1 virus
Researchers have discovered that the currently circulating 2.3.4.4b clade of H5N1 has specific mutations in its genome that increase its human adaptive potential.