One health
Communicable diseases remain one of the major causes of mortality worldwide. There are disparities in the numbers of individuals affected by disease between low-and-middle-income countries and those in developed nations. Microbes will play in important role in drug discovery: producing anticancer drugs and antimicrobials. Applying One Health principles, to understand the interaction of pathogens and the human host, development of diagnostics, treatments, and disease prevention, applied microbiologists can shape global health and wellbeing outcomes.
News
Cat disease challenges what scientists thought about coronaviruses
Researchers have uncovered new details about how a once-deadly coronavirus disease in cats spreads through the immune system. For years, the prevailing belief was that the virus behind feline infectious peritonitis infected just one type of immune cell.
Read story
NewsResearcher reveals secrets of bacteria that can swim upstream
Rather than washing pathogens away, strong fluid currents act as “guide rails” that align bacteria and accelerate their upstream migration. They discovered that this creates a “two-way invasion” where pioneer cells reach the source within minutes, seeding colonies that spread threefold faster than in still water.
NewsResearchers deploy bacteria to make healthier sugar substitute
Researchers have developed a way to biosynthetically produce an otherwise rare sugar called tagatose, which could very well provide the sweetness and natural taste of table sugar without its potential harms. It might even provide some health benefits.
NewsResearchers uncover the secret route of prostate infections
A research team has developed a “mini prostate” organoid model using adult stem cells. Using this model, the scientists could follow a bacterial prostatitis infection step by step under controlled conditions and identify exactly how the bacteria attack.
More One Health
News
UK: COVID-19 vaccine hesitancy decreased over time, though mistrust persists among certain groups
Most COVID-19 vaccine hesitancy is rooted in concerns that can be addressed and effectively reduced over time, according to a new study following more than 1.1 million people in England between January 2021 and March 2022 during the COVID-19 pandemic.
NewsChanges in genetic structure of yeast lead to disease-causing genomic instabilities
Researchers studying a yeast model have discovered that the loss of heterochromatin can kickstart genetic changes, potentially resulting in the development of diseases like cancer.
NewsClinical trial in Ethiopia targets the trachoma scourge
A new study documents the outcomes of an evaluation of fluorometholone as adjunctive medical therapy for trachomatous trichiasis surgery, part of an initiative to better prevent blindness and improve quality of life for those affected.
NewsNew study finds higher hantavirus risk in drier, underdeveloped areas
In a recent study of the contiguous USA, researchers found that the risk of disease from hantavirus is higher in drier, underdeveloped geographic areas with more socioeconomic vulnerability and increased numbers of unique rodent species.
NewsScientists decode tree genome to unlock terpenoid-based disease resistance
Researchers reported a chromosome-scale genome and multi-omics analysis of a Lauraceae medicinal tree. The study reveals how specific terpene synthase (TPS) genes contribute to antimicrobial compound production and enhanced resistance to plant diseases.
NewsResearchers revive failing antibiotics with two-faced Janus nanoparticles
Researchers have restored the power of failing antibiotics by combining them with two-sided nanoparticles, ultra-small building blocks of materials less than 100 nanometers across. The nanoparticles showed a remarkable ability to compromise bacterial cell walls, leaving them vulnerable to attack.
NewsEarthworms turn manure into a powerful tool against antibiotic resistance
Earthworms could become unexpected allies in the global fight against antibiotic resistance, by helping farmers turn manure into safer, high-value organic fertilizer through vermicomposting. Researchers report it can remove antibiotic resistance genes far more consistently than conventional composting.
NewsA tug-of-war explains a decades-old question about how bacteria swim
Whether a bacterium’s tail spins clockwise or counterclockwise was previously thought to depend on a ‘domino effect’ among proteins inside the tail. However, new research proposes that a tug-of-war is the deciding factor.
NewsHow Mtb safeguards itself from foreign DNA
Researchers have discovered how a key protein in the tuberculosis bacterium helps protect it from the influence of foreign DNA inserted into its genome. Understanding how this protein – called Lsr2 – functions could help develop drugs that target it, thereby aiding in the fight against TB.
NewsThe secret room a giant virus creates inside its host amoeba
Researchers examined Acanthamoeba polyphaga mimivirus-infected amoeba cells using a combination of sequencing methods, including Ribosome profiling to estimate the frequency of translation pausing and tRNA sequencing to determine tRNA composition.
NewsNew test shows which antibiotics actually work
Drugs that act against bacteria are mainly assessed based on how well they inhibit bacterial growth under laboratory conditions. A critical factor is whether the active substances actually kill the pathogens in the body. Researchers have presented a new method for measuring how effectively antibiotics kill bacteria.
NewsTB harnesses part of immune defense system to cause infection
Scientists have made a discovery that helps explain why humans and animals are so susceptible to contracting tuberculosis – and it involves the bacteria harnessing part of the immune system meant to protect against infection. They team discovered that MTB survives within the cells of its host by targeting Dectin-1.
NewsBiodegradable and conventional plastics shape very different antibiotic resistance risks in river microbiomes
Biodegradable plastics are not always safer for rivers and oceans, according to a new study that tracked how different plastics change the risk of antibiotic resistant bacteria over time in a real river.
NewsMelting glaciers may release hidden antibiotic resistance into vital water sources
Researchers report that glaciers act as long-term reservoirs of antibiotic resistance genes. Once released by glacier melt, these genes can enter rivers, lakes, and ecosystems that supply drinking water and support wildlife in polar and high-altitude regions.
NewsWhat causes some people’s gut microbes to produce high alcohol levels?
A study of people with a rare condition known as auto-brewery syndrome has found a link between gut microbes and symptoms of intoxication, pointing to new treatment strategies.
NewsPlastic particles can increase intestinal inflammation
Researchers investigating a possible link between the rising number of people with chronic inflammatory bowel disease and the increasing exposure to micro- and nanoplastics show that plastic particles influence the immune cells and the intestinal microbiome and can thus increase inflammation.
NewsVictoria’s Secret grant backs cutting-edge ovarian cancer research
Promising ovarian cancer research by Melanie Rutkowski, PhD, at the University of Virginia Comprehensive Cancer Center has won $700,000 in support from the Victoria’s Secret Global Fund for Women’s Cancers in partnership with Pelotonia and AACR, the American Association for Cancer Research.
NewsA high-protein diet can defeat cholera infection
A new study has found that diets high in casein, the main protein in milk and cheese, as well as wheat gluten, could make a dramatic difference in the amount of cholera bacteria able to infect the gut.
NewsStudy: How can we stop the spread of flu?
Researchers wanted to find out how the flu spreads, so they put college students already sick with the flu into a hotel room with healthy middle-aged adult volunteers. The result? No one caught the flu.