One health
Communicable diseases remain one of the major causes of mortality worldwide. There are disparities in the numbers of individuals affected by disease between low-and-middle-income countries and those in developed nations. Microbes will play in important role in drug discovery: producing anticancer drugs and antimicrobials. Applying One Health principles, to understand the interaction of pathogens and the human host, development of diagnostics, treatments, and disease prevention, applied microbiologists can shape global health and wellbeing outcomes.
News
Efficacy of commercial disinfectants Virkon®S and Microchem Plus against poliovirus
The WHO 4th Global Action Plan for Poliovirus Containment (GAPIV) mandates poliovirus-essential facilities (PEFs) to validate on-site decontamination protocols for non-enveloped poliovirus, a pathogen resistant to many routine disinfectants. A study assessed two commercial biosecurity disinfectants.
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NewsHospital expands newborn screening to identify virus that can lead to hearing loss and developmental delays
Researchers have developed a new screening program for congenital cytomegalovirus, the most common infection passed from mothers to babies during pregnancy. While many babies with congenital cytomegalovirus have no obvious symptoms, some can develop hearing loss, developmental delays or other medical complications as they grow.
NewsResearch could lead to better prevention for a common cause of newborn meningitis
A new research project will investigate how Strep B bacteria attach to the vaginal tract and the mechanisms they use to stay there. In newborns, Strep B infections can kill and the study will look at how Streptococcus agalactiae comes to colonize the birth canal in the first place, which may lead to improved preventative measures.
News€8 million Horizon Europe grant to launch next-generation initiative to detect, assess and respond to pandemics
Led by the University of Oxford in partnership with the WHO and an international consortium the three-year PANDAI project will develop and deploy advanced AI models to transform the detection, assessment, prediction and response to global disease threats.
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Nabsys announces first publication showcasing CRISPR/Cas9 mediated approach to expand the capabilities of electronic genome mapping
This study is the first to demonstrate the potential of combining Electronic Genome Mapping (EGM) with CRISPR/Cas9 to both characterize CRISPR/Cas9 activity and enhance the capabilities of genome mapping.
NewsScientists uncover genetic changes in the bacteria causing severe Kent meningococcal disease outbreak
Scientists have used bacterial genome sequencing to understand why the meningococcal disease outbreak in Kent earlier this year was so severe. The outbreak bacteria had picked up genetic material from other, less harmful bacteria found naturally in the throats of many healthy people.
NewsNew standardised, contemporary strain panels address a long-standing barrier in AMR research
PACE and the UK Health Security Agency have released five new contemporary antimicrobial resistance (AMR) strain panels, giving innovators worldwide a resource to test novel therapeutics and diagnostics against today’s resistance patterns.
NewsGut microbiome development may help predict type 1 diabetes in children at high risk
A new prospective study found that children at high genetic risk of type 1 diabetes whose gut microbiome development plateaued early had about three times the risk of developing the disease compared with children whose microbiomes continued to mature.
NewsHow a single viral protein hijacks immune cells to supercharge COVID-19 infection
A new discovery reveals how a SARS-CoV-2 protein reprograms immune cells to accelerate viral spread—and points to a new strategy for therapeutic intervention.
NewsBoosted BCG vaccine strategy significantly reduces tuberculosis relapse
A new study reveals that combining an immunotherapy with the traditional Bacille Calmette-Guérin (BCG) vaccine drastically lowers the risk of TB relapse in preclinical models.
NewsA tiny bacterium with a huge impact
Researchers have discovered that gut bacteria and the compounds they produce trigger biological processes that the human body on its own can only activate with difficulty. They help suppress inflammation and may also have beneficial effects on fatty liver disease.
NewsNew study uncovers how the malaria parasite boosts its transmission potential under stress conditions
Researchers reveal the molecular mechanism by which Plasmodium falciparum responds to stress by increasing the production of the sexual forms required for transmission.
NewsNew study uncovers the complex history of the plague after the Black Death
A new study sheds fresh light on the long and complex history of the plague by analysing the DNA of the bacterium. Researchers reconstructed 26 genomes of Yersinia pestis from archaeological sites in Estonia, Russia, England, the Netherlands, and Switzerland.
NewsA classic metabolic enzyme reveals a hidden role in broad-spectrum antiviral defense
Researchers find that the phosphoglycerate kinase 1 (PGK1) uses its non-canonical protein kinase activity to disrupt a host chaperone required by multiple viruses, suggesting a potential strategy for host-directed antiviral therapy.
NewsVaccination: why don’t we all experience the same side effects?
Researchers have found that, even before vaccination, some people’s innate immune systems are more reactive than others, showing a heightened response to interferons. The stronger this response, the more likely individuals are to experience these transient symptoms.
NewsOral chiral nanozyme protects the heart during chemotherapy by reshaping the gut-heart axis
A chirality-engineered nanozyme restores gut microbiota and host metabolism to prevent doxorubicin-induced cardiotoxicity without compromising anticancer efficacy.
NewsGlobal Virus Network comments on H5N1 detections in Australian mammals
The Global Virus Network (GVN) is closely monitoring detections of highly pathogenic avian influenza A (H5N1), commonly known as bird flu, in several mammal species in Australia as the virus continues to spread among birds and mammals worldwide.
NewsNew sepsis guidelines seek to reduce infection’s deadly toll
Experts have developed important new guidelines to improve care for patients who develop sepsis, a dangerous full-body infection that kills at least 350,000 Americans every year.
NewsLong-acting antibodies may work with the immune system to control HIV and help reduce the reservoir
Results from a clinical trial have offered a new HIV strategy, suggesting that just one or two doses of broadly neutralizing antibodies (bNAbs) can suppress the virus long-term, keeping it at undetectable levels for months and even years.
NewsUS officials suppressed warnings over flawed covid vaccine safety algorithm
US health officials knowingly relied on a compromised algorithm to detect signals of harm from mRNA covid-19 vaccines and silenced efforts to fix it, finds an investigation.
NewsTwo coronavirus master keys: new study unveils the mechanisms Covid-19 virus uses to enter our cells
To enter our cells, the Covid-19 virus fuses its surrounding membrane with the membrane of the target cell. The fusion peptides of the spike protein function as molecular keys that allow the virus to open the door to the target cell . A new study shows that SARS-CoV-2 does not have just one key, but two.
NewsNew test could dramatically speed diagnosis of hard-to-detect lung infections
Nontuberculous mycobacteria can cause chronic, tuberculosis-like lung infections. Researchers have developed a new diagnostic platform that can identify the precise species of bacteria causing a patient’s infection in just a few hours — a dramatic improvement over the current standard, which can take four to six weeks.
NewsNew method reveals how virus particles can build themselves, molecule by molecule
Researchers have captured the step-by-step assembly of individual virus-like particles, revealing how simple molecular interactions can reliably build these complex biological structures. The process works rather like finding a route through a maze in which only the productive turns lock into place.