One health
Communicable diseases remain one of the major causes of mortality worldwide. There are disparities in the numbers of individuals affected by disease between low-and-middle-income countries and those in developed nations. Microbes will play in important role in drug discovery: producing anticancer drugs and antimicrobials. Applying One Health principles, to understand the interaction of pathogens and the human host, development of diagnostics, treatments, and disease prevention, applied microbiologists can shape global health and wellbeing outcomes.
News
Researchers discover how tuberculosis bacteria use a “stealth” mechanism to evade the immune system
New research reveals that mycobacteria release tiny packages called extracellular vesicles that fuse with the membranes of immune cells. These vesicles contain specialized lipids—fatty molecules—that make the cell membrane more rigid.
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NewsPrenatal infection increases risk of heavy drinking later in life
Exposure to infection and other immune stress in the womb increases the likelihood of alcohol misuse in adulthood, a risk that may be reduced through prenatal antioxidant treatment, a new study shows.
NewsScientists discover ‘bacterial constipation’, a new disease caused by gut-drying bacteria
Scientists have found two gut bacteria working together that contribute to chronic constipation. The duo, Akkermansia muciniphila and Bacteroides thetaiotaomicron, destroy the intestinal mucus coating essential for keeping the colon lubricated and feces hydrated.
NewsMissing microbes in UK infant gut and probiotics highlighted by global microbiome atlas
A global atlas mapping two key gut bacteria in infants around the world has uncovered a treasure trove of bacterial strains adapted to the infant gut and not found in commercial probiotic products. It lays the foundation for more effective, tailored infant probiotics.
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News
A ring to transcribe them: The unique path of poxviruses
A study shows for the first time the mechanical elegance with which the viral protein VITF-3 controls the transcription process. Vaccinia viruses, the most widely studied model viruses from the poxvirus family, were examined at the molecular level.
NewsInvasive death cap mushrooms are changing their chemistry
Scientists have just published new research about the chemistry of death cap mushrooms (Amanita phalloides) - the species is not only spreading rapidly as an invasive fungal species in the United States, but the move across continents has changed the chemistry of the species.
NewsNovel vaccine protects against C. diff disease and recurrence
A novel vaccination approach cleared the harmful gut bacterium Clostridioides difficile in an animal model of infection. An experimental vaccine administered to the mucosal lining of the colon protected against illness, death, tissue damage and infection recurrence.
NewsGlobal scientific paper establishes first consensus definition of gut health
A global group of 13 scientists and clinicians is helping establish clarity by publishing a consensus definition of gut health. They define gut health as “a state of normal gastrointestinal function without active gastrointestinal disease and gut-related symptoms that affect quality of life.”
NewsAntimicrobial resistance in foodborne bacteria remains a public health concern in Europe
Antimicrobial resistance (AMR) in common foodborne bacteria such as Salmonella and Campylobacter continues to be a public health concern across Europe, according to a new joint report from EFSA and ECDC.
NewsComplexity key to preventing infection after heart surgery
Research indicates that uniform materials could be the culprit behind deadly infections that can occur when using synthetic materials for cardiovascular grafts.
NewsMacrophage immune cells need constant reminders to retain memories of prior infections
Researchers have discovered that immune cells known as macrophages remain poised to fight repeat infections due to the persistent presence of signaling molecules left behind during previous infections.
NewsPower grids to epidemics: study shows small patterns trigger systemic failures
Why do some systems collapse suddenly after what seems like a minor disturbance? In nature, a local disease outbreak can quickly escalate into an epidemic. New research suggests that in many cases, the key isn’t the entire system – but its smallest building blocks.
NewsBooster jabs reduce the risks of COVID-19 deaths, study finds
Booster vaccines reduced the risk of COVID‑19–related hospitalisation and death, according to a new study of over 3 million adults who had the autumn 2022 vaccine in England.
NewsDebilitating virus can spread in cool weather, increasing health risk in Europe
Chikungunya virus, a debilitating tropical disease caused by infected mosquito bites, poses a greater health threat in Europe than previously thought because it can be spread when air temperatures are as low as 13 degrees Celsius.
NewsHow bacteria may promote breast cancer
Researchers have discovered how certain pathogenic bacteria in gut and breast tissue can promote breast cancer development and progression by hijacking a key metabolic enzyme known as spermine oxidase (SMOX).
NewsScientists develop first-of-its-kind antibody to block Epstein Barr virus
Using mice with human antibody genes, scientists have developed new genetically human monoclonal antibodies that prevent two key antigens on the surface of the Epstein Barr virus (EBV) from binding to and entering human immune cells.
NewsStrategic changes in water treatment could prevent disease outbreaks
A breakthrough new study shows how strategic changes in water treatment effectively treated a deadly outbreak of Legionnaires’ Disease. For the first time, the study provides evidence of an outbreak being stopped by introducing disinfection to previously untreated groundwater.
NewsChildren with sleep apnea face higher risk of flu and COVID-19, new study finds
A five-year study has revealed that children with sleep apnea are twice as likely to contract the flu or COVID-19, regardless of their age or weight. Even after undergoing surgery to remove tonsils or adenoids, this increased vulnerability persists due to long-term changes in the immune system.
NewsNew antibody–drug conjugate strategy to block HIV infection
New antibody–drug conjugates (ADCs) combine a CD4 mimic with neutralizing antibodies for enhanced suppression of HIV infection. By targeting the gp120 on the viral envelope via a two-step mechanism, the ADCs effectively block viral entry.
NewsNew clinical guidelines to reduce central line-associated bloodstream infection
Central line-associated bloodstream infections remain a major challenge in ICUs. A team of clinicians has proposed updated guidelines to standardize the clinical practices addressing CLABSI, aiming to reduce infection rates and improve outcomes for critically ill patients.
NewsGlobal commitment on display as countries negotiate key annex to the Pandemic Agreement
Member States of the World Health Organization (WHO) concluded a weeklong round of negotiations on draft annex for Pathogen Access and Benefit Sharing (PABS) – a key component of the WHO Pandemic Agreement.
NewsNew biosensor offers early warning system for disease
Researchers have developed a tissue-adhesive sensor for real-time oral health monitoring to combat long-term issues such as gum disease and tooth loss.
NewsBacteria frozen in ancient underground ice cave found to be resistant against 10 modern antibiotics
Researchers tested antibiotic resistance profiles of a bacterial strain that until recently was hidden in a 5,000-year-old layer of ice of an underground ice cave – and found it could be an opportunity for developing new strategies to prevent the rise of antibiotic resistance.