One health
Communicable diseases remain one of the major causes of mortality worldwide. There are disparities in the numbers of individuals affected by disease between low-and-middle-income countries and those in developed nations. Microbes will play in important role in drug discovery: producing anticancer drugs and antimicrobials. Applying One Health principles, to understand the interaction of pathogens and the human host, development of diagnostics, treatments, and disease prevention, applied microbiologists can shape global health and wellbeing outcomes.
News
CARB-X to support investigation of Exhalon’s breath-based lower respiratory tract infection testing platform
CARB-X has awarded Exhalon US$1M in seed funding to evaluate whether exhaled breath can be used as a non-invasive sample type to aid in the rapid and accurate diagnosis of lower-respiratory tract infections (LRTIs).
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NewsStudy suggests that chlorine treatment may impact the risk of legionnaires’ disease
Preliminary results of a nationwide study suggest that the disinfectant used to treat water before it is distributed through pipes may impact the incidence of Legionnaire’s disease in certain parts of the country.
NewsInside the gut: What our poo could tell us about our diet, gut microbes and health
Researchers have found that molecules in stool samples can accurately reflect what people eat and how their gut microbiome responds, offering a potential new tool to study nutrition and its impact on health.
NewsStudy reveals how bacteria resist hostile attacks from rival bacteria
When attacked by bacteria from a different species, Pseudomonas rapidly assembles the type VI secretion system (T6SS) – to inject its aggressor with a toxic cocktail. A new study probes how Pseudomonas can strike back when it has already been hit by a deadly cocktail itself.
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News
Study unlocks the key microbes contributing to postnatal growth retardation
Postnatal growth retardation (PGR) has a high incidence during early postnatal development of piglets and humans. Researchers have found that hindgut-enriched Methanobrevibacter smithii compromises the weight gain in the pig PGR model.
NewsTuberculosis: Scientists develop novel drug candidate for combating resistant pathogens
Researchers have developed a promising new substance for targeting bacteria that cause tuberculosis. The team have produced a compound that inhibits the pathogens’ ability to produce energy and causes them to die.
NewsOld molecules show promise for fighting resistant strains of COVID-19 virus
SARS‑CoV‑2 continues to mutate, with some newer strains becoming less responsive to current antiviral treatments like Paxlovid. Now, researchers have identified several promising molecules that could lead to new medications capable of combating these resistant variants.
NewsHow can nursing homes protect more patients from infections?
New US national guidance calls for full-time infection prevention staff; more training, support and vaccination for all staff; and partnerships with hospitals and public health agencies.
NewsWhat are the new guidelines for infant hepatitis B vaccination?
Public health expert and infectious disease physician Janet A. Jokela comments after the Advisory Committee on Immunization Practices of the CDC voted to discontinue its decades-long recommendation for universal vaccination against hepatitis B beginning at birth.
NewsAFYREN and ESSE Skincare begin partnership to offer 100% natural cosmetic solutions with enhanced skincare performance
AFYREN, a greentech company offering manufacturers biobased, low-carbon ingredients through a unique fermentation technology, and South Africa-based Esse Skincare, a leader in microbiome skincare science, are partnering to introduce the world’s first bio-based propionic acid for the skincare industry.
NewsNew study reveals that parasite-produced dopamine can alter host behaviour
A new study has shed light on how Toxoplasma gondii, the causative agent of toxoplasmosis, can alter host behaviour. The research findings show that such behavioural changes are achieved, at least in part, through dopamine manipulation caused by dopamine produced by the parasite itself.
NewsMajor breakthrough against diabetes thanks to a microbial molecule that disarms inflammation
Researchers have uncovered a surprising ally in the fight against insulin resistance and type 2 diabetes: a microbial metabolite called trimethylamine. TMA, produced by gut bacteria from dietary choline can block a key immune pathway and improve blood sugar control.
NewsDose of psilocybin, dash of rabies point to treatment for depression
Researchers used a combination of psilocybin and the rabies virus to map how – and where – the psychedelic compound rewires the connections in the brain. Specifically, they showed psilocybin weakens the cortico-cortical feedback loops that can lock people into negative thinking.
NewsEngineered virus boosts immune response against glioblastoma in preclinical models
Researchers have modified a herpes simplex virus (HSV-1) that stimulates the immune system to attack glioblastoma cells. A single dose of the modified virus increased T-cell, natural killer cell, and myeloid cell responses in the tumor microenvironment and increased the overall survival in preclinical models.
NewsSocial lives of viruses affect antiviral resistance
Interactions among viruses can help them succeed inside their hosts or impart vulnerabilities that make them easier to treat. Scientists are learning the ways viruses mingle inside the cells they infect, as well as the consequences of their socializing.
NewsPlant phenolic acids supercharge old antibiotics against multidrug resistant E. coli
Plant derived phenolic acids can dramatically enhance the activity of existing antibiotics against multidrug resistant E. coli, offering a promising new tool in the global fight against antimicrobial resistance.
NewsMicroenvironment-feedback hydrogel enables precise staged repair of infected wounds
A research team has developed a hydrogel that can sense changes in wound pH and automatically switches its therapeutic behavior from fighting infection to promoting tissue repair.
NewsResearchers watch live as influenza viruses enter human cells
Using a microscopy technique that they developed themselves, scientists can zoom in on the surface of human cells in a Petri dish, observing live and in high resolution how influenza viruses enter a living cell. They found the cells are not passive, but actively attempt to capture the virus.
NewsChemists synthesize a fungal compound that holds promise for treating brain cancer
For the first time, chemists have synthesized a fungal compound known as verticillin A, which was discovered more than 50 years ago and has shown potential as an anticancer agent.
NewsPreviously unrecognized pathway in plants and phytoplankton offers mercury-detox powers
Primary producers—including phytoplankton—possess a previously overlooked ability to internally break down and detoxify methylmercury. The demethylation pathway rapidly converts methylmercury into less toxic inorganic mercury, which is subsequently reduced to gaseous Hg⁰.
News$1.9m grant supports research on chronic wounds
Assistant Professor Carolyn Ibberson at the University of Tennessee, Knoxville, has received a four-year, $1.9 million grant from the National Institutes of Health to support research on infections in chronic wounds.
CareersAMR in aquatic ecosystems: A One Health investigation in an irrigation dam in Thailand
Dr Kwanrawee Joy Sirikanchana outlines how her team has launched a major project to address an overlooked question: How much does aquaculture contribute to AMR in shared water systems, and what does this mean for people, animals, and wildlife living around them?
NewsResearchers identify bacterial enzyme that can cause fatal heart conditions with pneumonia infections
Researchers have identified a bacterial enzyme that may be the reason some people get heart complications with pneumonia, while others do not. Since enzymes create chemical reactions to help bacteria survive, grow, and sometimes attack tissues, zmpB could become a target for future therapies.