One health
Communicable diseases remain one of the major causes of mortality worldwide. There are disparities in the numbers of individuals affected by disease between low-and-middle-income countries and those in developed nations. Microbes will play in important role in drug discovery: producing anticancer drugs and antimicrobials. Applying One Health principles, to understand the interaction of pathogens and the human host, development of diagnostics, treatments, and disease prevention, applied microbiologists can shape global health and wellbeing outcomes.
News
Bacteria ‘pills’ could detect gut diseases — without the endoscope
Researchers report that they’ve developed a sensor made of tiny microspheres packed with blood-sensing bacteria that detect markers of gastrointestinal disease. Taken orally, the miniature “pills” also contain magnetic particles that make them easy to collect from stool. Excreted from mouse models with colitis, the bacterial sensor detected gastrointestinal bleeding within minutes.
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NewsGSK and Fleming Initiative scientists unite to target AMR with advanced AI
GSK and the Fleming Initiative have announced six major new research programmes, called ‘Grand Challenges’ which harness some of the best scientific expertise and the latest technologies, including advanced AI, to find new ways to slow the progress of antimicrobial resistance (AMR).
NewsProbiotic bifidobacterium may boost cancer treatment and suppress tumors
A new review explores how bifidobacterium, a common probiotic found in the gut, may contribute to cancer prevention and therapy. The authors highlight the growing importance of gut health in cancer treatment and shed light on how bifidobacterium could complement standard cancer therapies.
NewsGut bacterium impairs liver cancer treatment, inducing immunotherapy resistance
Researchers discovered that transplanting the gut bacterium Phocaeicola vulgatus into mouse models of liver cancer induced immunotherapy resistance. The finding is consistent with clinical observations in patients, showing that patients with low levels of P. vulgatus responded better to treatment.
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Scripps Research scientists receive $1.1 million to advance AI modeling for HIV vaccine development
Scripps Research scientists will purchase high-performance computing equipment to accelerate the identification of more effective HIV vaccine candidates through enhanced computational infrastructure, reduced data-processing bottlenecks, and state-of-the-art artificial intelligence (AI) technology.
News$3.7 million awarded for research into sand flies, vectors of parasitic disease leishmaniasis
Professor Gideon Wasserberg at UNC Greensboro has been awarded a prestigious $3.7 million National Institutes of Health R01 grant to advance his research on controlling sand flies, the vectors of the parasitic disease leishmaniasis.
NewsResearchers expand virus-based treatment options for antibiotic-resistant infections
Phages are extremely specific about which strains of a bacterial species they will attack. This has limited their effectiveness against the most antibiotic-resistant strains. To overcome this problem, the research team “trained” the phages by allowing them to evolve together with the bacteria in a controlled laboratory setting for 30 days.
NewsPhase 2 clinical trial results show potential to shorten TB treatment time
New clinical trial results show that the novel antibiotic candidate sorfequiline (TBAJ-876), a next-generation diarylquinoline, has the potential to improve tuberculosis (TB) treatment when combined with pretomanid and linezolid in a treatment regimen known as “SPaL.”
NewsDid US cities’ indoor vaccine mandates affect COVID-19 vaccination rates and outcomes?
New research reveals that despite widespread adoption of indoor vaccine mandates in major US cities during the COVID-19 pandemic, there is no consistent evidence that these policies significantly increased vaccination rates or reduced COVID-19–related outcomes. The findings contrast with those from other countries, as national mandates abroad boosted vaccine uptake.
NewsGreen chemistry for sustainable personal care
A recent review examined microbial biosurfactants as sustainable alternatives to synthetic surfactants in shampoo formulations. The authors addressed the growing demand for environmentally friendly and dermatologically safe cleansing agents, and emphasized the need to transition from petrochemical-based ingredients such as sodium lauryl sulfate (SLS) to biodegradable biosurfactants.
NewsVaccine skepticism on social media can predict public health crises
Researchers have developed a new approach that could help public health officials predict where outbreaks might occur. By analyzing social media posts, the method identifies early signs of increasing vaccine skepticism — a warning signal that could emerge before any disease begins to spread.
NewsMicropores pave the way for infection research
Organ-on-a-chip technology often contains gels that imitate the 3D environment of our tissues - however, many of these gels are too dense, hindering the passage of microbes and immune cells, and movement is essential to recreate how infections really develop. In this study, the research team developed a new type of porous gel that solves this problem.
NewsTime to act and not react: how can the European Union turn the tide of antimicrobial resistance?
Despite determined efforts by countries and healthcare professionals, Europe is not on track to meet four of the five AMR targets set by the EU Council for 2030*, according to data released on EAAD.
NewsApriori Bio and A*STAR Infectious Diseases Labs Announce strategic partnership to advance next generation influenza vaccines
Apriori Bio and the Agency for Science, Technology and Research Infectious Diseases Labs (A*STAR IDL) announced a strategic research partnership to co-develop and evaluate next generation self-amplifying RNA (saRNA) vaccines targeting seasonal and pandemic influenza.
NewsMedications change our gut microbiome in predictable ways
A study shows that many of the changes to the gut microbiome are driven by competition for nutrients – medications reduce certain bacterial populations and change the availability of nutrients, and the bacteria most able to capitalize on those changes are the ones to survive.
NewsWastewater from most countries favours non-resistant bacteria
Municipal wastewater contains a large range of excreted antibiotics and has therefore long been suspected to be a spawning ground for antibiotic-resistant bacteria. By testing the potential of untreated municipal wastewater from 47 countries to select for resistant E. coli, researchers show that while some samples indeed do so, most instead suppress them.
NewsHepatitis E virus from rats can also infect humans in individual cases – a new zoonotic pathogen?
It has only been known for a few years that humans can also be infected with a variant of the hepatitis E virus that is usually prevalent in rats. Following reports of individual cases, mainly from Hong Kong and Spain, the first infection with ratHEV has now also been described in a patient from Germany.
NewsSugar transporter discovery offers promising avenue for improving antibiotic efficacy
Scientists have recently demonstrated that aminoglycosides enter bacteria by using sugar transporters. They have also successfully doubled the number of transporters, even in the most resistant Escherichia coli strains, thus improving antibiotics’ penetration rate and efficacy.
NewsSingle-celled organisms found to have a more complex DNA epigenetic code than multicellular life
Researchers discovered that in more ‘primitive’ unicellular organisms, both the adenine and the cytosine bases are methylated. This would suggest that in some ways, these unicellular organisms are more complex than their multicellular peers.
NewsA new gateway to global antimicrobial resistance data
To support global AMR research, EMBL’s European Bioinformatics Institute (EMBL-EBI) has launched the AMR portal, a central hub that connects bacterial genomes, resistance phenotypes, and functional annotations, all in one place. The AMR portal ensures long-term availability, standardisation, and reusability of AMR data.
CareersSummer studentship: Megan investigates the mobile gene element that gives MRSA its clout
Megan Stenton reports back on her AMI-sponsored summer studentship which investigated the frequency of the SCCmec gene - a mobile gene element that houses the methicillin resistance gene - across members of the same species of Staphylococcus aureus.
NewsTraces of bacteria inside brain tumors may affect tumor behavior
Scientists have uncovered unexpected traces of bacteria within brain tumors. This discovery offers new insights into the environment in which brain tumors grow and sets the stage for future studies seeking to improve treatment outcomes.
NewsNext-generation microbiome medicine may revolutionize the treatment of Parkinson’s and similar disorders
Scientists have engineered the probiotic bacterium Escherichia coli Nissle 1917 as a drug-delivery system that continuously produces and delivers the gold-standard Parkinson’s drug Levodopa, which is converted to dopamine in the brain. E. coli Nissle strain was chosen for its century-long record of safely treating gastrointestinal disorders in humans.