One health
Communicable diseases remain one of the major causes of mortality worldwide. There are disparities in the numbers of individuals affected by disease between low-and-middle-income countries and those in developed nations. Microbes will play in important role in drug discovery: producing anticancer drugs and antimicrobials. Applying One Health principles, to understand the interaction of pathogens and the human host, development of diagnostics, treatments, and disease prevention, applied microbiologists can shape global health and wellbeing outcomes.
News
New study reveals that parasite-produced dopamine can alter host behaviour
A new study has shed light on how Toxoplasma gondii, the causative agent of toxoplasmosis, can alter host behaviour. The research findings show that such behavioural changes are achieved, at least in part, through dopamine manipulation caused by dopamine produced by the parasite itself.
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NewsMajor breakthrough against diabetes thanks to a microbial molecule that disarms inflammation
Researchers have uncovered a surprising ally in the fight against insulin resistance and type 2 diabetes: a microbial metabolite called trimethylamine. TMA, produced by gut bacteria from dietary choline can block a key immune pathway and improve blood sugar control.
NewsDose of psilocybin, dash of rabies point to treatment for depression
Researchers used a combination of psilocybin and the rabies virus to map how – and where – the psychedelic compound rewires the connections in the brain. Specifically, they showed psilocybin weakens the cortico-cortical feedback loops that can lock people into negative thinking.
NewsEngineered virus boosts immune response against glioblastoma in preclinical models
Researchers have modified a herpes simplex virus (HSV-1) that stimulates the immune system to attack glioblastoma cells. A single dose of the modified virus increased T-cell, natural killer cell, and myeloid cell responses in the tumor microenvironment and increased the overall survival in preclinical models.
More One Health
News
Social lives of viruses affect antiviral resistance
Interactions among viruses can help them succeed inside their hosts or impart vulnerabilities that make them easier to treat. Scientists are learning the ways viruses mingle inside the cells they infect, as well as the consequences of their socializing.
NewsPlant phenolic acids supercharge old antibiotics against multidrug resistant E. coli
Plant derived phenolic acids can dramatically enhance the activity of existing antibiotics against multidrug resistant E. coli, offering a promising new tool in the global fight against antimicrobial resistance.
NewsMicroenvironment-feedback hydrogel enables precise staged repair of infected wounds
A research team has developed a hydrogel that can sense changes in wound pH and automatically switches its therapeutic behavior from fighting infection to promoting tissue repair.
NewsResearchers watch live as influenza viruses enter human cells
Using a microscopy technique that they developed themselves, scientists can zoom in on the surface of human cells in a Petri dish, observing live and in high resolution how influenza viruses enter a living cell. They found the cells are not passive, but actively attempt to capture the virus.
NewsChemists synthesize a fungal compound that holds promise for treating brain cancer
For the first time, chemists have synthesized a fungal compound known as verticillin A, which was discovered more than 50 years ago and has shown potential as an anticancer agent.
NewsPreviously unrecognized pathway in plants and phytoplankton offers mercury-detox powers
Primary producers—including phytoplankton—possess a previously overlooked ability to internally break down and detoxify methylmercury. The demethylation pathway rapidly converts methylmercury into less toxic inorganic mercury, which is subsequently reduced to gaseous Hg⁰.
News$1.9m grant supports research on chronic wounds
Assistant Professor Carolyn Ibberson at the University of Tennessee, Knoxville, has received a four-year, $1.9 million grant from the National Institutes of Health to support research on infections in chronic wounds.
CareersAMR in aquatic ecosystems: A One Health investigation in an irrigation dam in Thailand
Dr Kwanrawee Joy Sirikanchana outlines how her team has launched a major project to address an overlooked question: How much does aquaculture contribute to AMR in shared water systems, and what does this mean for people, animals, and wildlife living around them?
NewsResearchers identify bacterial enzyme that can cause fatal heart conditions with pneumonia infections
Researchers have identified a bacterial enzyme that may be the reason some people get heart complications with pneumonia, while others do not. Since enzymes create chemical reactions to help bacteria survive, grow, and sometimes attack tissues, zmpB could become a target for future therapies.
NewsTo treat long COVID, we must learn from historical chronic illnesses, medical researchers say
Scientists and doctors have highlighted the importance of studying long COVID in the context of other post-acute infection syndromes or chronic illnesses. By analyzing historical accounts of other epidemics, researchers can gain important perspective on the effects of these chronic illnesses.
NewsDo oral bacteria from tooth infections worsen diabetes risk?
A new study demonstrates that Porphyromonas gingivalis and its lipopolysaccharide are potent drivers of both periapical bone destruction and systemic metabolic dysfunction, acting through an IL-17–dependent inflammatory pathway.
NewsThe power of gut enzymes: why healthy eating affects everyone differently
Researchers have uncovered a mechanism that determines how our gut microbiome processes healthful plant compounds. The chemical cookbook of gut bacteria varies from person to person—and is often disrupted in chronic diseases.
NewsResearchers use ‘brain-on-a-chip’ to revolutionize fight against deadly encephalitis viruses
A transparent chip no larger than a stick of gum is helping scientists transform the way researchers study the human brain and develop treatments for some of the world’s deadliest viruses.
NewsNew roadmap reveals how everyday chemicals and microbes interact to fuel antimicrobial resistance
A new perspective outlines an urgent scientific roadmap for understanding how common chemicals interact with microbial communities to accelerate the global crisis of antimicrobial resistance.
NewsMental health conditions may heighten liver cancer risk in veterans due to increased hepatitis C
Mental health conditions, especially alcohol use disorder and post-traumatic stress disorder (PTSD), significantly increase the likelihood of developing liver cancer among U.S. veterans living with cirrhosis of any cause.
NewsStudy shows common childhood virus can drive bladder cancer development
Tackling a common childhood virus could open the door to preventing bladder cancer, according to new research. The study suggests that a virus most people pick up in childhood can trigger the type of DNA damage that can lead to bladder cancer later in life.
NewsNew test distinguishes vaccine-induced false positives from active HIV infection
A new device correctly identified those with active HIV-1 infection 95% of the time and those without active infection but with vaccine-induced molecules that could trigger a false positive, 98% of the time.
NewsFamily dogs boost adolescent mental health through the microbiome
It’s no surprise that dogs benefit people’s mental health. Researchers point to a reason as to why: dogs prompt changes in the collection of microbes that live in and on our bodies, resulting in an increase in mental health.
NewsCedars-Sinai and Exobiosphere partner to launch biomedical research aboard the Haven-1 Space Station
Cedars-Sinai is partnering with Exobiosphere, a company that has developed scientific hardware to automate biomedical research in space and on Earth, and will send experiments to Haven-1, set to become the world’s first commercial space station.