One health
Communicable diseases remain one of the major causes of mortality worldwide. There are disparities in the numbers of individuals affected by disease between low-and-middle-income countries and those in developed nations. Microbes will play in important role in drug discovery: producing anticancer drugs and antimicrobials. Applying One Health principles, to understand the interaction of pathogens and the human host, development of diagnostics, treatments, and disease prevention, applied microbiologists can shape global health and wellbeing outcomes.
News
Roasted and browned: how gut bacteria break down heated foods
Heating food generates new dietary compounds. A study shows that an enzyme in gut bacteria can expand its functional repertoire to process them.
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NewsEven invertebrates can specifically distinguish between bacteria
Researchers have found that the immune system of a sea anemone is capable of selectively distinguishing between different microorganisms and thus protecting beneficial over harmful bacteria – an ability that has only been attributed to vertebrates to date.
NewsScientists map how the flu virus rewires the human cell from the inside
Researchers have gained new insights into how the influenza A virus reprograms cellular machinery by tracking molecular interactions directly inside infected cells.
NewsLast-line antibiotics at risk as children’s resistance rises
Antimicrobial resistance in children is rising globally and will worsen over the next decade, threatening the effectiveness of life‑saving antibiotics, according to a world-first monitoring platform.
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When it comes to brain health, is microbiome science missing much of the world?
For more than two decades, scientists have uncovered remarkable links between the trillions of microbes living in our gut and the health of our brains. What if much of this science is based on studying only a narrow slice of global diversity?
NewsCOVID-19 vaccines remain effective despite helminth-induced immune modulation
In a preclinical study, researchers have found that mRNA- and protein-based SARS-CoV-2 vaccines effectively protected Schistosoma-infected mice against the virus, despite the mice’s distinct immune response profiles.
NewsNew Piem concept proposed: Reshaping human microbiome research and opening a new chapter in precision medicine
Researchers systematically proposed the novel concept of “Persistent Intracellular Extraintestinal Microbes” (PIEM). This expands the scope of microbiome research from external surfaces to the body’s interior.
NewsExpanding uses for bioengineered bacterial spores
Fused to the outer layer of bacterial spores, things like enzymes, biosensors, and drugs are easily stored under even extreme conditions.
NewsFrog protein could become first antidote to deadly red tide toxin
Red tide algal blooms produce one of the most potent neurotoxins known: saxitoxin, or STX. Researchers have found that a protein called saxiphilin can neutralize saxitoxin in mice, preventing and even reversing otherwise lethal poisoning.
NewsResearchers to tackle overlooked tropical disease
Two researchers are teaming up to build foundational knowledge concerning leishmaniasis, a common, but neglected protozoan parasitic disease. The project combines research into the cell biology of membrane repair with parasitology knowledge.
NewsNovel antifungal drug shows promise in some patients with Valley Fever
A study found that olorofim, a first-in-class orotomide antifungal agent, showed efficacy in patients with disseminated coccidioidomycosis (DCM), a rare complication of Valley Fever where the fungus spreads from the lungs to other parts of the body.
NewsMultisite test strip boosts mosquito-borne virus detection
A research team has developed a multisite bridging-mediated lateral flow immunoassay (mbLFIA) that enables highly sensitive, portable detection of mosquito-borne viruses, using Chikungunya virus (CHIKV) as a model target.
NewsAntivaccine legislation is rising rapidly in US states, driven primarily by GOP push
A new study revealed that Republican lawmakers were responsible for 86 per cent of antivaccine bills introduced across state legislatures after the onset of the COVID-19 pandemic, raising concerns about public health.
NewsData may reveal the hidden communication of pathogenic fungi
Researchers creating the first comprehensive fungal EV atlas will investigate vesicles produced by fungi belonging to the Candida, Aspergillus and Cryptococcus genera, while also working to standardise the methods used for their isolation and analysis.
NewsWHO Member States continue negotiations on the Pathogen Access and Benefit Sharing Annex
WHO Member States have advanced negotiations on the Pathogen Access and Benefit Sharing (PABS) annex, while agreeing that continued discussions are needed to finalize a framework that supports a faster, more effective and equitable response to future pandemics.
NewsHow bacteria sacrifice themselves to render antibiotics ineffective
Bacteria can defend themselves against antibiotics with the help of an enzyme released by dying cells, reveals a study that helps scientists understand the survival mechanisms of bacteria and to improve the effectiveness of antibiotics.
NewsNew approaches against fungal infections discovered
Researchers have used state-of-the-art cryo-electron microscopy to decode the structure of a key fungal transporter - the UapA transporter of the model fungus Aspergillus nidulans.
NewsCyanobacterial toxins can be inhaled
Research on Southwest Florida cyanobacterial blooms shows that the toxins they produce are aerosolized, potentially being inhaled by people far from contaminated water bodies.
News COVID-19 booster strategies provide lasting immunity
Smaller doses of COVID-19 booster vaccines can provide long-lasting immunity, helping to reduce costs and improve access to vaccination, according to research. The findings could also inform vaccine dosing and options during future pandemics.
NewsPartners launch development of a portable rapid diagnostic system for Ebola virus disease
Professor Yasutoshi Kido of the Graduate School of Medicine, Osaka Metropolitan University (OMU), in collaboration with K.K. DNAFORM and the National Institute for Biomedical Research (INRB) of the Democratic Republic of the Congo, is developing a portable rapid diagnostic system for Ebola virus disease (EVD) caused by Bundibugyo virus (BDBV). ...
NewsDrug-resistant gonorrhea on the rise in Europe, ECDC warns
An increasing number of European countries have detected gonococcal strains resistant to the antibiotic ceftriaxone, the first-line drug to treat gonorrhea infection.
NewsROS–Jak2/Stat3 signaling drives HBV-induced liver inflammation
Scientists investigated the mechanisms underlying HBV-induced liver inflammation and identified a reactive oxygen species (ROS)-dependent signaling cascade that activates the Jak2/Stat3 pathway, thereby triggering hepatic inflammatory responses.
FeaturesAdvancing animal disease outbreak management in support of a One Health approach
Animal health is often overlooked, with global expenditure reaching just a fraction (around 0.4 percent) of total human health spending, yet it is a crucial component of the World Health Organization’s (WHO) One Health approach. The One Health initiative highlights the commonalities between human, animal and environmental health and aims ...