Communicable diseases remain one of the major causes of mortality worldwide. There are disparities in the numbers of individuals affected by disease between low-and-middle-income countries and those in developed nations. Microbes will play in important role in drug discovery: producing anticancer drugs and antimicrobials. Applying One Health principles, to understand the interaction of pathogens and the human host, development of diagnostics, treatments, and disease prevention, applied microbiologists can shape global health and wellbeing outcomes.
Viruses may carry a molecular ‘barcode’ hidden not just in their genetic sequence, but in the way their RNA folds and vibrates. Researchers have used Raman spectroscopy to distinguish 20 SARS-CoV-2 variants and subvariants, pointing towards a potentially faster way to screen emerging viral strains.
Read storyResearchers have found a way to amplify one of the body’s natural antiviral defence pathways, making cells significantly more resistant to infection. By boosting signalling through the protein ISG15, the approach could lead to host-directed treatments that remain effective even as viruses mutate.
Some bacteriophages can quietly replicate inside bacteria for generations without killing their hosts, making these infections difficult to detect with standard methods. A new research project will investigate this hidden life cycle and explore whether understanding it could help scientists engineer more effective phage therapies against drug-resistant infections.
Cleaner operating-room air may not be enough to prevent surgical infections. In a study of more than 110,000 procedures, advanced air-purification systems did not reduce infections, complications or deaths, suggesting hospitals may gain more by targeting direct contamination of surgical wounds.
Pure cranberry juice may do more than add a tart kick to the holiday table. In a small human study, it slowed dental plaque growth and reduced acid production, suggesting the fruit’s natural compounds could help protect tooth enamel.
Researchers found that macaque monkeys who had lived through a deadly disease outbreak became significantly more cautious about food that appeared contaminated, even though they did not know how the disease had spread. The findings suggest that pathogen-avoidance behavior can be shaped by experience, offering clues about the evolutionary roots of disgust.
Researchers ound no evidence that genetic factors played an important role in determining who was hospitalised with COVID-19. Instead, spouses of hospitalised individuals had more than three times the risk of being hospitalised themselves compared with matched controls.
Researchers examining whether COVID-19 vaccination affects persistent smell or taste problems after contracting the virus have found that, in most cases, it does not.
A new clinical trial is testing whether probiotics can help patients with ovarian cancer better tolerate chemotherapy. The trial will look at whether probiotics can help reduce treatment side effects and improve quality of life. Researchers will also study how changes in the gut microbiome may be linked to treatment response.
Beginning the global COVID-19 vaccine roll-out 100 days after the virus was sequenced could have saved more than 8 million lives by the end of 2021, most of them in lower-middle-income countries. The authors of a new Policy Brief argue that fair vaccine-sharing rules should be established before the next pandemic, rather than negotiated during the crisis itself.
A Michigan Medicine-led research consortium has secured approval for up to $52 million in federal funding to launch a multicenter study examining why some young children recover fully from viral lower respiratory tract infections while others develop severe illness or lasting problems such as asthma.
Bay Area Lyme Foundation has announced the opening of applications for the 2027 Emerging Leader Awards (ELA), which recognize researchers identifying innovative approaches to solve the challenges of Lyme and tick-borne illnesses.
Professor Chris Greening, Professor of Microbiology at Monash University in Australia, has been named as the winner of the WH Pierce Global Impact in Microbiology Prize.
Researchers have developed a label-free surface-enhanced Raman scattering (SERS) analysis technology that rapidly detects extremely low concentrations of viable bacteria by directly growing plasmonic metal nanostructures on and around bacterial cells.
Postmenopausal women are at greater risk for multiple health issues, such as hip fractures and urinary tract infections (UTIs), due to estrogen loss. Vaginal estrogen is used to prevent recurrent UTIs, but a new study suggests its use may be associated with perioperative hip fracture complications, like UTIs.
A single subcutaneous injection of a live, unattenuated influenza virus can provide durable protection against lethal flu without causing lung damage, according to new findings that challenge the long-standing trade-off between the safety of inactivated vaccines and the potent immunity of live vaccines.
A review brings together the virology, epidemiology, clinical features, diagnosis, and treatment of human hantavirus infection and examines what each means for the mouth and for dental care.
A modeling study suggests that replacing universal hepatitis B vaccination at birth with delayed vaccination or a shared decision-making approach, as recommended by the U.S. federal government this year, could lead to substantially more chronic hepatitis B infections among U.S. children.
A new research centre in Berlin is aiming to move HIV care beyond lifelong treatment and towards cure or long-term remission. Building on two rare HIV cures achieved in the city, researchers will investigate antibody, immune, gene and cell therapies designed to eliminate the virus or keep it permanently under control without medication.
Plague may sound like a disease from the history books, but Yersinia pestis still circulates in wildlife around the world. Despite recent concern over a possible laboratory-linked death in Russia, experts stress that human cases remain rare and the infection is usually treatable when diagnosed quickly.
The tiny finger-like structures lining our small intestine have inspired a new design for bacteria-powered batteries. By mimicking intestinal villi, researchers created a bioelectrode with more surface area and better nutrient flow, allowing bacteria to generate stable electricity for hours.
Researchers have uncovered previously unknown viruses that appear to bridge the evolutionary gap between viruses and protein compartments found inside cells. The discovery suggests these systems may have evolved from one another repeatedly, offering new clues about the origins of cellular organisation and the early evolution of life.
Vegan honey alternatives could be engineered to have similar antimicrobial properties to prized mānuka honey from New Zealand, according to research. Two components of mānuka honey proved to be particularly effective when added to vegan honey formulations - methylglyoxal (MGO) and hydrogen peroxide.