All cyclic dinucleotides articles
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NewsScientists reveal key bacterial immune mechanism
Researchers have uncovered a pivotal mechanism by which bacteria defend themselves against viral infection. Cyclic dinucleotides (CDNs), synthesized during activation of the cyclic oligonucleotide-based anti-phage signaling system (CBASS) immune mechanism, trigger the filamentous assembly of phospholipase effectors, which execute the downstream immune response.