Innovation – Page 3
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News Engineered moths could replace mice in research into “one of the biggest threats to human health”
Scientists have created the world’s first genetically engineered wax moths – a development which could both accelerate the fight against antimicrobial resistance (AMR) and significantly reduce the need for mice and rats in infection research.
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NewsNext generation genetics technology developed to counter the rise of antibiotic resistance
The new Pro-Active Genetics (Pro-AG) tool called pPro-MobV is a second-generation technology that uses an approach similar to gene drives to disable drug resistance in populations of bacteria.
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News
New vaccine platform promotes rare protective B cells
Based on a virus-like particle built with a DNA scaffold, the approach could generate broadly neutralizing antibody responses against HIV or influenza.
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NewsA mint idea becomes a game changer for medical devices
Researchers have developed a high‑performance coating made from peppermint essential oil that can be applied to the surfaces of many commonly used medical devices, offering a safer way to protect patients from infection and inflammation.
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NewsYeast cells can be used for rapid testing of cancer immunotherapy
An international research team has developed a new yeast-based biotechnological platform that makes it possible to test and understand advanced cancer treatments much faster and cheaper than before. It can reduce development time for new types of cancer immunotherapy from months to days or weeks.
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NewsFrom biocidal coatings to medicines: A nanocomposite sting for microorganisms
A surface capable of responding to chemical signals generated by microorganisms and automatically producing biocidal substances – a description of how the B-STING silica nanocomposite works. The new material acts as a nanofactory of reactive oxygen species, activating only when necessary.
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NewsNasal vaccine combats bird flu infection in rodents
Researchers have developed an intranasal H5N1 vaccine that elicited strong immune responses when tested in hamsters and mice and prevented infections in exposed animals. The team also confirmed their vaccine remained effective regardless of prior flu exposure.
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NewsA rapid test using a mobile phone will be able to identify the most severe cases of imported malaria within minutes
A new malaria tool uses a mobile phone to combine rapid diagnostic tests with video analysis and is capable not only of detecting the infection in under six minutes but also of predicting which patients may develop severe forms of malaria.
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NewsNew tool shows how to enter and change pneumocystis fungi
Researchers have reported success in genetically modifying the fungal pathogen Pneumocystis murina. Their approach uses extracellular vesicles from mouse lungs to deliver gene-modifying molecules inside the fungal cells. The modified fungus expressed the introduced genomic modifications.
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NewsGlowing bacterial sensors detect gut illness in mice before symptoms emerge
Researchers have engineered gut bacteria that dim their fluorescent glow in the presence of illness. Their findings could improve how we diagnose problems in the gut by using bacteria that already live there.
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NewsScientists use AI to uncover the secret lives of fungi
Scientists have developed an automated workflow that assesses scientific abstracts and accurately identifies whether a fungus has a single lifestyle or a dual, flexible one. Understanding this flexibility is vital for predicting how forests and farms will react to climate change.
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NewsNew platform could develop vaccines faster than ever before
Scientists are optimizing a vaccine-development platform created to accelerate how quickly life-saving vaccines can be designed and deployed during infectious-disease outbreaks such as the COVID-19 pandemic.
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NewsScientists develop novel live-attenuated vaccine that blocks coronavirus transmission with a single intranasal dose
A research team at the LKS Faculty of Medicine, the University of Hong Kong (HKUMed), has developed a novel live-attenuated vaccine candidate, cb1, capable of generating broad immunity against a wide range of beta-coronaviruses with a single intranasal dose. Source: NIAID-RML This colorized transmission electron microscope image shows ...
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NewsScientists engineer quantum-enabled proteins, opening a new frontier in biotechnology
A new study reports the creation of a new class of biomolecules, magneto-sensitive fluorescent proteins, that can interact with magnetic fields and radio waves. This is enabled by quantum mechanical interactions within the protein, and occur when it is exposed to light of an appropriate wavelength.
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NewsGolden Gate method enables rapid, fully-synthetic engineering of therapeutically relevant bacteriophages
Researchers have described the first fully synthetic bacteriophage engineering system for Pseudomonas aeruginosa. In this method, researchers engineer bacteriophages synthetically using sequence data rather than bacteriophage isolates.
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NewsBrewing a rare medicine: yeast engineered to produce a valuable astragalus isoflavonoid
By reconstructing the complete biosynthetic pathway inside Saccharomyces cerevisiae and systematically removing metabolic bottlenecks, researchers created the first yeast platform capable of producing calycosin-7-glucoside from simple carbon sources.
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NewsReconstructing nature’s oxindole factory: yeast-based biosynthesis of medicinal indole alkaloids
By identifying four key enzymes from a North American plant and reconstituting them in yeast, scientists have achieved complete de novo biosynthesis of complex oxindole molecules that are difficult to obtain from plants or chemical synthesis.
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NewsEngineered yeast delivers record levels of animal-free chondroitin sulfate
A new study establishes a robust yeast-based platform that overcomes the long-standing trade-off between yield and sulfation, enabling sustainable, high-level production of high-quality chondroitin sulfate without reliance on animal sources.
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NewsEngineering yeast to make rare anticancer saponins: reconstructing the complete biosynthesis of polyphyllin II
By combining plant transcriptomics, enzyme engineering, and synthetic biology, a new study demonstrates, for the first time, the full heterologous production of polyphyllin II in Saccharomyces cerevisiae.
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NewsScientists develop new biosynthetic route to optically pure S-2-Hydroxyisovalerate
By uncovering an unexpected enzyme activity and combining it with precise metabolic engineering, scientists has transformed Escherichia coli into a microbial factory capable of producing gram-per-liter levels of optically pure S-HIV from renewable carbon sources.