All Mark Brönstrup articles
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NewsNew agent inhibits Staphylococcus aureus toxin – hope for pneumonia patients
Researchers have developed a miniaturized test system that allowed them to screen over 180,000 compounds for their ability to block the effect of the key virulence factor α-hemolysin in S aureus. Drug candidates from the quinoxalinedione class, in particular the compound H052, proved to be highly effective, both in cell culture and in animal models.
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NewsTowards improved pandemic preparedness: Launch of new EU project COMBINE
A project for the targeted development of antiviral therapies for newly emerging viruses, COMBINE focuses on the critical virus-cell binding step, aiming to identify key factors and potential therapeutic targets involved early in viral infections.
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NewsChemical trick activates antibiotic directly at the pathogen
Scientists have seen promising results after experimenting with a click-to-release approach that deploys a masked form of colistin to the site of an infection so that it is no longer as damaging to the kidneys while maintaining its high antibiotic efficacy.