All Plasmodium falciparum articles
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NewsNew antimalarial drug candidate shows potential for fighting resistance and reducing malaria transmission
Researchers have developed a new antimalarial drug candidate designed to address the growing challenge of drug resistance and potentially reduce malaria transmission.
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NewsNew compound cuts off protein supply to parasites
There is an urgent need for new active ingredients that are capable of circumventing existing resistances in malaria. Researchers have now identified a new drug candidate, ’Substance 31’, which could enable the development of a new malaria drug.
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NewsNew monoclonal antibody shows promise for preventing malaria infections
A new early-stage clinical trial has found that a novel monoclonal antibody provided dose-dependent full protection against the malaria parasite with minimal side effects.
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NewsResearchers probe how malaria harms unborn babies
UK-based Wellcome has awarded over €2 million to an international research effort to uncover how malaria can injure developing babies.
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NewsToxoplasmosis: how the pathogen exploits its own envelope
Researchers have developed a novel imaging technique that allows reliable visualization of the process of endocytosis in Toxoplasma for the first time. The material enters the pathogen through a micropore in its cell membrane.
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NewsSubstances isolated from marine sponges show potential for treating malária
In pre-clinical tests, compounds called batzelladins were found to be effective even against strains of Plasmodium that are resistant to conventional antimalarial drugs.
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NewsPair of malaria parasite proteins could lead to targeted therapies
Scientists have made an advance in the basic understanding of Plasmodium falciparum, the parasite responsible for the deadliest form of human malaria, that could make novel, highly targeted anti-malarial therapies possible.
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NewsTargeting malaria parasite’s protein control system could be key to innovative treatments
By inducing protein aggregation in Plasmodium falciparum, researchers have observed considerable disorders in protein homeostasis and a significant reduction in parasite growth.
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NewsNew malaria control strategy efficiently kills parasites in the mosquito
A potent combination of antimalarial compounds added to bed nets blocked parasite transmission in mosquitoes while circumventing insecticide resistance, according to a new study.
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NewsNovel molecular maneuver helps malaria parasite dodge the immune system
Researchers have discovered how a parasite that causes malaria when transmitted through a mosquito bite can hide from the body’s immune system. Plasmodium falciparum can shut down a key set of genes, rendering itself “immunologically invisible.”
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NewsFamily of parasite proteins presents new potential malaria treatment target
Researchers from the Francis Crick Institute and the Gulbenkian Institute for Molecular Medicine (GIMM) have shown that the evolution of a family of exported proteins in the malaria-causing parasite Plasmodium falciparum enabled it to infect humans. Source: Ernst Hempelmann Ring stage of Plasmodium falciparum in human red blood ...
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NewsCutting off parasite’s energy supply could help fight malaria
Once inside the body of an infected person, the malaria parasite relies on a process called glycolysis to produce energy and stay alive. Blocking the enzymes involved in this process could cut off the parasite’s primary energy source and kill it.
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NewsStudy identifies how malaria can lead to childhood cancer
New data has uncovered the role of Plasmodium falciparum infection (malaria) in the development of Burkitt lymphoma (BL), the most common childhood cancer in equatorial Africa and New Guinea.
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NewsPromising new class of antimalarial drugs discovered
A new study identifies an inhibitor of gene regulation that specifically kills the malaria pathogen. The chromatin remodeler PfSnf2L is a key regulator of genes that play an important role in various stages of the pathogen’s development.
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NewsScientists explain how a compound from sea sponge exerts its biological effects
Girolline, a compound extracted from the sea sponge Pseudaxinyssa cantharella, has been investigated for possible antitumor effects and also found to have anti-malarial effects. Now researchers have a better idea of how it works.
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NewsNew discovery provides hope in fighting drug-resistant malaria
Researchers have described how they may have found a new target in Plasmodium falciparum, the deadliest malaria parasite: a cholesterol-managing protein called PfNCR1.
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NewsGlobal research uncovers critical weakness in malaria parasite
Scientists exploring how immunity develops against Plasmodium falciparum found that broadly reactive antibodies from various individuals consistently bound to the same site on a key virulence protein of the malaria parasite.
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NewsA new approach to predicting malaria drug resistance
Researchers analyzed the genomes of hundreds of malaria parasites to determine which genetic variants are most likely to confer drug resistance.
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NewsNew tool reveals how malaria sticks to red blood vessels
Scientists have unveiled a new tool for studying the highly variable traits that allow malaria parasites to stick to red blood cells and evade the immune system.
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NewsHuman antibodies could prevent the malaria parasite from causing life-threatening infections
Malaria, particularly in its severe forms, remains a global health and economic burden. It causes the deaths of more than 600,000 people every year – most of them African children under five. In a new study, published in the journal Nature, researchers from EMBL Barcelona, the University of Texas, the ...