All Plasmodium falciparum articles
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NewsResearchers identify potential new route for antimalarial drug design
Researchers have uncovered a promising new potential target for drug discovery. The team focused on an enzyme called aminopeptidase P (PfAPP) from Plasmodium falciparum, the parasite responsible for the most severe form of malaria in humans.
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NewsMalaria’s mRNA: Messages that mess with the immune system
A new study uncovers the malaria parasite’s RNA strategies – mechanisms that could inspire unexpected applications for RNA-based tools in multiple areas of medicine.
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NewsPlasmodium uses its own PI3K to suppress eat-me signal and evade host immune clearance
A study finds that Plasmodium PI3K actively suppresses the externalization of phosphatidylserine on the surface of infected erythrocytes. When the activity of parasite PI3K was chemically inhibited or genetically disrupted, phosphatidylserine exposure on infected red blood cells increased markedly.
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NewsSeparating signal from noise: How African biostatisticians are reshaping the fight against malaria
Biostatistics is unlocking smarter malaria solutions, linking parasite diversity, vaccines, and human behaviour to drive more effective prevention and protection.
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NewsMalaria shaped distribution of early human populations
Scientists investigated whether Plasmodium falciparum induced malaria shaped human habitat choice between 74,000 and 5,000 years ago, finding that malaria influenced habitat choice by pushing human groups away from high-risk environments and separating populations across the landscape.
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NewsMalaria: Newly identified ‘crown’ stage controls parasite reproduction
Researchers studying Plasmodium falciparum have found that the parasite relies on a brief but essential stage, nicknamed the “Crown” stage, to make sure a crucial internal structure is passed on correctly when it divides.
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NewsA rapid test using a mobile phone will be able to identify the most severe cases of imported malaria within minutes
A new malaria tool uses a mobile phone to combine rapid diagnostic tests with video analysis and is capable not only of detecting the infection in under six minutes but also of predicting which patients may develop severe forms of malaria.
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NewsScientists identify potential therapy and diagnostic markers for cerebral malaria
Researchers examined whether methylene blue could mitigate brain injury during severe malaria, and whether a practical set of blood biomarkers could help clinicians identify cerebral malaria early and track how patients respond to treatment.
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NewsNew antimalarial drug candidate shows potential for fighting resistance and reducing malaria transmission
Researchers have developed a new antimalarial drug candidate designed to address the growing challenge of drug resistance and potentially reduce malaria transmission.
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NewsNew compound cuts off protein supply to parasites
There is an urgent need for new active ingredients that are capable of circumventing existing resistances in malaria. Researchers have now identified a new drug candidate, ’Substance 31’, which could enable the development of a new malaria drug.
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NewsNew monoclonal antibody shows promise for preventing malaria infections
A new early-stage clinical trial has found that a novel monoclonal antibody provided dose-dependent full protection against the malaria parasite with minimal side effects.
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NewsResearchers probe how malaria harms unborn babies
UK-based Wellcome has awarded over €2 million to an international research effort to uncover how malaria can injure developing babies.
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NewsToxoplasmosis: how the pathogen exploits its own envelope
Researchers have developed a novel imaging technique that allows reliable visualization of the process of endocytosis in Toxoplasma for the first time. The material enters the pathogen through a micropore in its cell membrane.
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NewsSubstances isolated from marine sponges show potential for treating malária
In pre-clinical tests, compounds called batzelladins were found to be effective even against strains of Plasmodium that are resistant to conventional antimalarial drugs.
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NewsPair of malaria parasite proteins could lead to targeted therapies
Scientists have made an advance in the basic understanding of Plasmodium falciparum, the parasite responsible for the deadliest form of human malaria, that could make novel, highly targeted anti-malarial therapies possible.
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NewsTargeting malaria parasite’s protein control system could be key to innovative treatments
By inducing protein aggregation in Plasmodium falciparum, researchers have observed considerable disorders in protein homeostasis and a significant reduction in parasite growth.
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NewsNew malaria control strategy efficiently kills parasites in the mosquito
A potent combination of antimalarial compounds added to bed nets blocked parasite transmission in mosquitoes while circumventing insecticide resistance, according to a new study.
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NewsNovel molecular maneuver helps malaria parasite dodge the immune system
Researchers have discovered how a parasite that causes malaria when transmitted through a mosquito bite can hide from the body’s immune system. Plasmodium falciparum can shut down a key set of genes, rendering itself “immunologically invisible.”
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NewsFamily of parasite proteins presents new potential malaria treatment target
Researchers from the Francis Crick Institute and the Gulbenkian Institute for Molecular Medicine (GIMM) have shown that the evolution of a family of exported proteins in the malaria-causing parasite Plasmodium falciparum enabled it to infect humans. Source: Ernst Hempelmann Ring stage of Plasmodium falciparum in human red blood ...
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NewsCutting off parasite’s energy supply could help fight malaria
Once inside the body of an infected person, the malaria parasite relies on a process called glycolysis to produce energy and stay alive. Blocking the enzymes involved in this process could cut off the parasite’s primary energy source and kill it.