All Plasmodium falciparum articles
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NewsTargeting malaria parasite’s protein control system could be key to innovative treatments
By inducing protein aggregation in Plasmodium falciparum, researchers have observed considerable disorders in protein homeostasis and a significant reduction in parasite growth.
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NewsNew malaria control strategy efficiently kills parasites in the mosquito
A potent combination of antimalarial compounds added to bed nets blocked parasite transmission in mosquitoes while circumventing insecticide resistance, according to a new study.
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NewsNovel molecular maneuver helps malaria parasite dodge the immune system
Researchers have discovered how a parasite that causes malaria when transmitted through a mosquito bite can hide from the body’s immune system. Plasmodium falciparum can shut down a key set of genes, rendering itself “immunologically invisible.”
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NewsFamily of parasite proteins presents new potential malaria treatment target
Researchers from the Francis Crick Institute and the Gulbenkian Institute for Molecular Medicine (GIMM) have shown that the evolution of a family of exported proteins in the malaria-causing parasite Plasmodium falciparum enabled it to infect humans. Source: Ernst Hempelmann Ring stage of Plasmodium falciparum in human red blood ...
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NewsCutting off parasite’s energy supply could help fight malaria
Once inside the body of an infected person, the malaria parasite relies on a process called glycolysis to produce energy and stay alive. Blocking the enzymes involved in this process could cut off the parasite’s primary energy source and kill it.
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NewsStudy identifies how malaria can lead to childhood cancer
New data has uncovered the role of Plasmodium falciparum infection (malaria) in the development of Burkitt lymphoma (BL), the most common childhood cancer in equatorial Africa and New Guinea.
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NewsPromising new class of antimalarial drugs discovered
A new study identifies an inhibitor of gene regulation that specifically kills the malaria pathogen. The chromatin remodeler PfSnf2L is a key regulator of genes that play an important role in various stages of the pathogen’s development.
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NewsScientists explain how a compound from sea sponge exerts its biological effects
Girolline, a compound extracted from the sea sponge Pseudaxinyssa cantharella, has been investigated for possible antitumor effects and also found to have anti-malarial effects. Now researchers have a better idea of how it works.
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NewsNew discovery provides hope in fighting drug-resistant malaria
Researchers have described how they may have found a new target in Plasmodium falciparum, the deadliest malaria parasite: a cholesterol-managing protein called PfNCR1.
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NewsGlobal research uncovers critical weakness in malaria parasite
Scientists exploring how immunity develops against Plasmodium falciparum found that broadly reactive antibodies from various individuals consistently bound to the same site on a key virulence protein of the malaria parasite.
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NewsA new approach to predicting malaria drug resistance
Researchers analyzed the genomes of hundreds of malaria parasites to determine which genetic variants are most likely to confer drug resistance.
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NewsNew tool reveals how malaria sticks to red blood vessels
Scientists have unveiled a new tool for studying the highly variable traits that allow malaria parasites to stick to red blood cells and evade the immune system.
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NewsHuman antibodies could prevent the malaria parasite from causing life-threatening infections
Malaria, particularly in its severe forms, remains a global health and economic burden. It causes the deaths of more than 600,000 people every year – most of them African children under five. In a new study, published in the journal Nature, researchers from EMBL Barcelona, the University of Texas, the ...
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NewsStudy provides first evidence of African children with severe malaria experiencing partial resistance to world’s most powerful malaria drug
A new study from Uganda provides the first evidence to date that resistance to a lifesaving malaria drug may be emerging in the group of patients that accounts for most of the world’s malaria deaths: young African children suffering from serious infections.
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NewsNoninvasive malaria test could be global game changer
Researchers present a new noninvasive test that could dramatically alter the global malaria testing landscape by providing reliable, safe, and sensitive testing to low- and middle-income countries.
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NewsScientists design new drug to fight malaria
Scientists have designed a new drug against malaria and identified its mechanism of action. MED6-189 is effective against drug-sensitive and drug-resistant P. falciparum strains in vitro as well as in a humanized mouse model.
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NewsFirst-of-its-kind vaccine expands malaria protection for pregnant women
For the first time, immunization with a malaria vaccine has been shown to protect mothers from malaria during pregnancy and to protect for two transmission seasons without booster doses of vaccine.
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NewsNew agent effective against drug-resistant malaria parasites
Scientists have developed a promising new antimalarial agent, DIF-1(+3), which is a derivative of Dictyostelium differentiation-inducing factor-1 (DIF-1).
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NewsUrgent action needed to combat rising antimalarial resistance in Africa
Urgent action is needed to prevent a surge in malaria-related sickness and death in eastern Africa, scientists say.
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NewsLow birth weight linked to placental malaria in first-time mothers
A new study aimed to determine the prevalence of placental malaria infection, risk factors, types of Plasmodium causing malaria during pregnancy, and its relationship with neonatal birth weight among primigravidae.