Biobattery researchers have created a solution based on microbial fuel cells that would allow cameras to target the hard-to-reach small intestine, which winds around the human gut for an average of 22 feet.
“There are some regions in the small intestine that are not reachable, and that is why ingestible cameras have been developed to solve this issue,” said Professor Seokheun “Sean” Choi, lead researcher and faculty member in the Department of Electrical and Computer Engineering at Binghamton University, State University of New York.
“They can do many things, such as imaging and physical sensing, even drug delivery. The problem is power. So far, the electronics are using primary batteries that have a finite energy budget and cannot function for the long term.”
The Watson team’s solution builds on findings that Choi has made over the past decade about utilizing bacteria to create low levels of electricity that can power sensors and Wi-Fi connections.
Other options inside the small intestine are less viable: Traditional batteries are potentially harmful, wireless power transfer from outside the body is inefficient, temperature differences aren’t enough to harness thermal energy and intestinal movement is too slow for mechanical energy. Instead, Choi’s biobatteries utilize microbial fuel cells with spore-forming Bacillus subtilis bacteria that remain inert until they reach the small intestine.
“How do you make your micro-fuel cell selectively work in the small intestine? We use a pH-sensitive membrane that requires certain conditions to activate,” Choi said.
“When you look at our gastrointestinal tract, the esophagus has a neutral pH, the same as the small intestine, but the transit time is only 10 seconds. It will not activate in this area, and it will never work in the stomach because the stomach has a very low pH. It only works in the small intestine.
“We use these spores as a dormant, storable biocatalyst. The spores can be germinated when the nutrients are available, and they can resume vegetative life and generate the power.”
Although this research has just been published, Choi and his students already are looking ahead to improving the capsule-sized biobatteries. Once the fuel cell reaches the small intestine, it takes up to an hour to germinate completely — but faster would be better.
The cell generates around 100 microwatts per square centimetre of power density — enough for wireless transmission, but 10 times more would offer many more options for use. The batteries also would require animal and human testing as well as biocompatibility studies.
Choi can foresee several uses that low-level microbial fuel cells could power, including biological and chemical sensors, drug-delivery systems and electrical stimulation devices.
“I believe that our micro-fuel cell has a huge potential, but we have a long way to go,” he said.
The research team included PhD students Maryam Rezaie and Zahra Rafiee.
The paper, “A Biobattery Capsule for Ingestible Electronics in the Small Intestine: Biopower Production from Intestinal Fluids Activated Germination of Exoelectrogenic Bacterial Endospores,” was published in Advanced Energy Materials.
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