All Ruhr University Bochum articles
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NewsHep E virus can live out entire life cycle in kidney cells
Scientists have succeeded in proving in cell culture that hepatitis E viruses can infect kidney cells and can multiply with their help. The entire replication cycle of the virus takes place in kidney cells in the same way as in liver cells, their study shows.
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NewsScientists uncover shortcut to miniaturized hydrogen production
Researchers have figured out a way to simplify the highly complex hydrogenase biocatalyst to facilitate its integration into industrial processes, offering a route to clean energy.
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NewsYeast produces human DNase1 for the first time
The protein DNase1 is used to treat cystic fibrosis but it takes considerable effort and cost to produce it in immortalized hamster cells. Researchers have now produced it in yeast cells for the first time.
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NewsScientists ID previously unknown enzymes that can produce potentially antimicrobial agents
Micro-organisms generate potential agents for combating bacteria and fungi. Researchers have identified and optimized enzymes that can specifically generate a certain functional group of these natural substances, expanding the toolkit of potential agents.
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NewsNovel point of attack to combat dangerous tropical diseases
Researchers have compiled a high-precision inventory of the membrane proteins of cell organelles of the African sleeping sickness pathogen, offering hope for new treatment approaches for dangerous tropical diseases.
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NewsOnly few disinfectants are capable of inactivating hepatitis A virus
Researchers tested nine different surface disinfectants against Hepatitis A virus. According to their findings, only two aldehyde-based products proved effective at inactivating HAV.
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NewsInsight into key enzyme paves way towards hydrogen from algae
Researchers investigating algae that can produce hydrogen have identified how a vital cofactor, the so-called hydrogen cluster, is assembled.
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NewsPathway into cell influences the outcome of SARS-CoV-2 infection
The protein TMPRSS2 acts as a helper to bring the virus into the cell via the receptor ACE2. This TMPRSS2-mediated uptake significantly alters the immune response of the host cells and drives the evolution of the virus, a new study shows.
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NewsPeople with infections feel less empathy for others, study reveals
When people are ill, they feel less empathy for others than when they are healthy, as confirmed by a study which investigated ’sickness behavior’, whereby the body reorganizes its biological priorities in the context of acute infection.
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NewsResearchers detect hepatitis viruses in wastewater
High-throughput sequencing of river water samples showed that it is possible to identify different genetic variants of the hepatitis E virus in wastewater.
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NewsMutating hepatitis viruses make drug treatment more difficult
Sofosbuvir and Ribavirin combination therapy efficiently decreased viral RNA in blood and stool in patients with chronic HEV infection, but variants that are associated with antiviral resistance emerged during treatment.
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NewsNew method builds fluorescent nanotubes to detect bacteria and viruses
Researchers have developed a new approach to construct modular optical sensors which are capable of detecting viruses and bacteria.
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NewsSingle hepatitis E mutation renders sofosbuvir therapy ineffective
A single mutation of the hepatitis E virus has been shown to cause treatment with the hepatitis C drug sofosbuvir to become much less effective, according to a study that provides new insights for future drug development.
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NewsMonkeypox virus remains stable on surfaces for days
Researchers warn that it is extremely important to disinfect surfaces to decrease the risk of monkeypox in the event of an outbreak.
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NewsScientists unlock indole in soil bacteria to create prodrugs
Researchers from Bochum and Leipzig have successfully used a soil bacterium to specifically produce prodrugs. The key to this step was a detailed understanding of the metabolisation of indole, a natural compound which first must be activated in microorganisms. To do this, they needed a monooxygenase, the molecular structure of ...
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NewsSpotlight on how hepatitis E is able to infect cells
A recently developed cell culture model has finally made it possible for researchers to investigate how hepatitis E is able to infect cells.
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NewsIncrease in multidrug-resistant pathogens since Ukraine war
Researchers in Germany have recommended screening patients from Ukraine for multi-drug resistant pathogens prior to hospital admission following a series of outbreaks.
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NewsResearchers modify hydrogen-producing enzyme to protect it from oxygen destruction
Researchers have genetically modified a hydrogen-producing enzyme so that it is protected from oxygen, countering a key barrier to producing molecular hydrogen with enzymes from bacteria and algae.