All macrophages articles
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NewsPenicillin–streptomycin influences macrophage mechanical properties and microenvironment mechano-sensation
A foundational finding in mechanobiology reveals that penicillin-streptomycin (pen-strep), the antibiotic mixture universally added to mammalian cell culture media, is not a biologically inert antimicrobial agent.
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NewsResearchers uncover how bacteria suppress immune defences in stubborn wound infections
A common bacterium can suppress the body’s early warning system in wounds, causing infections to persist and create an environment that allows other bacteria to take hold. Enterococcus faecalis releases large amounts of lactic acid in the wound, which lowers pH, weakens immune cells and prevents them from fighting an infection.
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NewsMacrophage immune cells need constant reminders to retain memories of prior infections
Researchers have discovered that immune cells known as macrophages remain poised to fight repeat infections due to the persistent presence of signaling molecules left behind during previous infections.
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News3′UTR-derived small RNA couples acid resistance to metabolic reprogramming in Salmonella within macrophages
Salmonella expresses the arginine decarboxylase AdiA, which confers acid resistance by catalyzing an H+-consuming reaction. Researchers have discovered that the 3′-untranslated region (UTR) of adiA mRNA is processed by RNase E into a regulatory small RNA, AdiZ.
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NewsTB and HIV treatments are not enough for a full recovery
Existing treatments control TB and HIV, but the immune system does not revert to normal, helping explain why people living with HIV remain susceptible to infections and underscoring the need for immunotherapies.
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NewsToxic gut bacteria may drive ulcerative colitis by killing protective immune cells
A toxin-secreting gut bacterium may fuel ulcerative colitis by killing protective immune cells that maintain intestinal homeostasis, according to a new study. The findings suggest potential for new treatment strategies.
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NewsRebalancing the gut: how AI solved a 25-year Crohn’s disease mystery
Researchers have settled a decades-long debate surrounding the role of the first Crohn’s disease gene to be associated with a heightened risk for developing the auto-immune condition.
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NewsNew study reveals diverse threats from Avian E. coli
New research has determined why various strains of Avian Pathogenic E. coli behave so differently. The study analysed a colibacillosis outbreak in turkeys in the UK, and found a strain called ST-101 was the dominant cause of the outbreak, accounting for nearly 60% of cases.
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NewsCould targeted steroid use offer a universal complimentary treatment to fight TB?
Newly published research provides evidence that treating patients with steroids may enhance the function of their macrophages to kill the mycobacteria, while diminishing pathways of inflammatory damage.
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NewsSurvival trick: Pathogen taps iron source in immune cells
The body defends itself against pathogens by depriving them of vital iron. However, researchers have discovered that Salmonella bacteria specifically target iron-rich regions within immune cells to replicate, evading the immune defense.
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NewsStudy reveals how dextran sulfate sodium-induced colitis exacerbates periodontitis
A new study provides strong evidence that the NOX2/ROS axis plays a key role in the exacerbation of periodontitis in the presence of colitis.
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NewsCOVID-19 discovery opens door to new treatments for chronic lung problems
A discovery was made to understand how severe viral infections, like COVID-19 and flu could destroy the ability of immune cells to repair the tissue damage in lungs, causing long COVID and other chronic lung diseases.
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NewsBacteria consumed by immune cells become part of the cell
Immune cells that eat bacteria in the body don’t stash them in specialized compartments as once thought, but turn them into critical nutrients that build proteins, create energy and keep the cells alive, according to a new study.
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NewsStudy uncovers porcine reproductive and respiratory syndrome virus’s impact on swine immunity
Scientists used single-cell RNA analysis to reveal key immune mechanisms in lungs of swine infected with PRRSV. They found higher numbers of protective anti-inflammatory M2-like macrophages (SPP1-CXCL14high) were observed in less virulent infections, suggesting a potential role in promoting lung healing.
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NewsBad bacteria can trigger painful gut contractions; new research shows how
After a meal of questionable seafood or a few sips of contaminated water, bad bacteria can send your digestive tract into overdrive. Your intestines spasm and contract, efficiently expelling everything in the gut. Source: Parthasarathy Lab and Guillemin Lab Immune cells (magenta) and cells expressing a reporter of ...
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NewsResearcher targets BV, a common infection affecting women
A biomedical professor is targeting one of the most common – and dangerous – infections in women. With the help of a five-uear grant, she will study Bacterial Vaginosis (BV) and, ultimately, offer more effective personalized treatments.
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NewsScientists discover new process to drive anti-viral immunity
Scientists have discovered a new process in our immune systems that leads to the production of an important family of anti-viral proteins called interferons.
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NewsCould a bout of COVID protect you from a severe case of flu?
More than 200 viruses can infect and cause disease in humans; most of us will be infected by several over the course of a lifetime. Does an encounter with one virus influence how your immune system responds to a different one?
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NewsImmunotherapy for gum disease? Study in mice shows promise
Delivering microparticles containing the immune-modulating compound CCL2 directly to the gums inhibited bone loss and sped up bone repair in a mouse model of periodontal disease, new research has found.
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NewsSuper cally molecules take down tuberculosis
Researchers have identified and synthesised a group of molecules that can act against the cause of tuberculosis in a new way. The callyaerins act against TB by employing a fundamentally different mechanism compared to antibiotic agents used to date.