All malaria articles
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Across eight Amazon countries, forests on Indigenous lands reduce spread of 27 diseases
New research finds that municipalities in the Amazon region closest to healthy forests on Indigenous lands face less risk from rising cases of two categories of disease: cardiovascular and respiratory diseases due to forest fires and illnesses.
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Malaria vaccine mimics natural immunity with high precision
A detailed analysis reveals one of the reasons why the R21/Matrix-M malaria vaccine works so well: the antibodies generated following vaccination are indistinguishable from those found in people who have been infected by the parasites.
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Chemical trick could turn losing malaria drug into a winner
A new generation of malaria drugs failed clinical trials, in part because they were hard to swallow. Chemists have remodeled their structures to make them more soluble, while maintaining their effectiveness against drug-resistant parasites.
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Revealed: New vaccine target to block malaria transmission
Researchers have visualised a key protein complex in malaria parasites for the first time, uncovering a new target for next-generation vaccines that could help stop the disease from spreading.
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Vaccination could mitigate climate-driven disruptions to malaria control
Tropical cyclones in Madagascar lead to sharp spikes in malaria infections – particularly in children – due to interruptions in control efforts, according to a new study. However, newly introduced long-lasting vaccines can help to mitigate these gaps.
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New insights into malaria: Proteins in the blood can reveal the severity of the disease
Researchers have identified over 250 proteins that are strongly affected by malaria, which could help predict the severity of the disease and thus enable faster treatment for the most critical patients.
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Substances isolated from marine sponges show potential for treating malária
In pre-clinical tests, compounds called batzelladins were found to be effective even against strains of Plasmodium that are resistant to conventional antimalarial drugs.
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New strategy developed to engineer high-affinity receptor-containing antibodies against malaria
Researchers have introduced an innovative approach to developing high-affinity receptor-containing antibodies in vitro, offering a promising strategy to combat malaria.
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Paper-based devices diagnose malaria in asymptomatic people
Devices made with cheap strips of paper have outperformed two other testing methods in detecting malaria infection in asymptomatic people in Ghana – a diagnostic advance that could accelerate efforts to eliminate the disease, researchers say.
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Study highlights role of jaundice-associated pigment in protecting against malaria
New research suggests that a pigment that causes yellowing of the skin, or jaundice, may help protect people from the most severe consequences of malaria.
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Scholars take a new look at controversial Stateville prison malaria research 75 years ago
Medical ethicists are shining a light on a buried part of the malaria research conducted on inmates at Illinois’ Stateville Penitentiary 75 years ago.
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Targeting malaria parasite’s protein control system could be key to innovative treatments
By inducing protein aggregation in Plasmodium falciparum, researchers have observed considerable disorders in protein homeostasis and a significant reduction in parasite growth.
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New malaria control strategy efficiently kills parasites in the mosquito
A potent combination of antimalarial compounds added to bed nets blocked parasite transmission in mosquitoes while circumventing insecticide resistance, according to a new study.
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Novel molecular maneuver helps malaria parasite dodge the immune system
Researchers have discovered how a parasite that causes malaria when transmitted through a mosquito bite can hide from the body’s immune system. Plasmodium falciparum can shut down a key set of genes, rendering itself “immunologically invisible.”
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The Global Fund to fight AIDS, Tuberculosis and Malaria ‘should step up efforts’
The international community must protect global responses to HIV, tuberculosis (TB), and malaria to serve humanity’s collective interests, according to a new opinion article.
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Study identifies how malaria can lead to childhood cancer
New data has uncovered the role of Plasmodium falciparum infection (malaria) in the development of Burkitt lymphoma (BL), the most common childhood cancer in equatorial Africa and New Guinea.
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A 'Trojan Horse' approach to develop new antimalarial drugs
Researchers have discovered a key process whereby malarial parasites take up a human blood cell enzyme, which could provide a new approach for antimalarial treatment.
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Promising new class of antimalarial drugs discovered
A new study identifies an inhibitor of gene regulation that specifically kills the malaria pathogen. The chromatin remodeler PfSnf2L is a key regulator of genes that play an important role in various stages of the pathogen’s development.
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New study sheds light on the causes of fevers of unknown origin in sub-Saharan Africa
By conducting a retrospective observational study, the causes of fevers of unknown origin (FUO) in sub-Saharan Africa were investigated using conventional diagnostic methods, highlighting the appropriate needs of point-of-care testing in the regions.
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Scientists map essential genome of malaria parasite Plasmodium knowlesi
Comprehensive genetic mapping of Plasmodium knowlesi, a zoonotic parasite that causes malaria, has revealed the genes required for malaria infection of the blood, and those driving drug resistance.