All National University of Singapore articles
-
NewsSafer, more effective vaccines with new mRNA vaccine technology
A new messenger ribonucleic acid (mRNA) vaccine technology could make future vaccines safer, more effective, and less burdensome for patients. The new approach uses albumin-recruiting lipid nanoparticles to deliver mRNA precisely to lymph nodes while bypassing the liver.
-
NewsResearchers uncover hidden plant–microbe strategy that boosts crop growth under nutrient stress
Scientists discovered that when soil microbes compete with each other in the rhizosphere, they release a well-known compound called glutathione. This compound enhances plant growth under sulphur-deficient conditions.
-
NewsMap of bacterial gene interactions reveals potential drug targets
Researchers have developed a new technique called Dual transposon sequencing (Dual Tn-seq), which allows for rapid identification of genetic interactions. It maps how bacterial genes work together, revealing vulnerabilities that could be targeted by future antibiotics.
-
NewsScientists uncover molecular mechanisms for bacterial lipid transport
Researchers have successfully applied cryo-electron microscopy (cryo-EM) to unveil the molecular structures of critical protein machines that transport lipids and maintain the outer membrane (OM) barrier of Gram-negative bacteria.
-
-
NewsEngineered gut bacteria improves survival outcomes in colorectal cancer tumors
A genetically modified Salmonella typhimurium strain can colonise tumours and release a therapeutic protein, LIGHT, to induce the formation of mature tertiary lymphoid structures (mTLSs) in laboratory models.
-
NewsNanoparticle smart spray helps crops block infection before it starts
As climate change fuels the spread of plant diseases worldwide, a new nanoparticle smart spray could help crops defend themselves by blocking harmful bacteria from entering through tiny pores in their leaves.
-
NewsScientists introduce new engineered drug candidate for Mycobacterium abscessus to save lives
Scientists have introduced a promising drug candidate engineered to target a deadly and emerging infection. They took a hyper-detailed look into the problem of Mycobacterium abscessus, and chemically re-engineered a widely-used rifamycin antibiotic.
-
NewsResearchers develop UV and machine learning-aided method to detect microbial contamination in cell cultures
This is the first novel technology that utilises machine learning to analyse unique ultraviolet light “fingerprints” on cell cultures to quickly identify the presence of contamination.
-
NewsBreaking antibiotic-resistant bacteria’s protective shields opens door for immune system response
Researchers have made progress in uncovering how Streptococcus pneumoniae constructs its capsule, which serves as a protective shield. This capsule is a primary target for vaccine development.
-
NewsGround-breaking technique deploys bacterium to deliver drugs directly to the brain
A landmark study using the nasal bacteria technique promises new treatments for neurological disorders by bypassing the blood-brain barrier.
-
NewsA realistic ‘micro-gut’ model reflects the relationship between gut microbes and human diseases
An innovative and more physiologically relevant 3D micro-gut model, known as Gut-Microbiome on a chip (GMoC), provides an in-depth understanding of the complex interactions between the microbial community within the gut microbiome and their impacts on human gut health.
-
-
NewsStudy uncovers how dengue virus hijacks human plasmin for infection
Scientists characterized and revealed the correct structural bindings between dengue virus and human plasmin from mosquito blood meal to allow better understanding in dengue virus pathogenesis.
-
NewsScientists lift lid on Salmonella dry surface biofilm
Food scientists have revealed key characteristics of the foodborne pathogen Salmonella dry surface biofilm (DSB), a previously overlooked type of biofilm that commonly exists in dry food processing environments.
-
NewsBioengineered yeast microbes as targeted drug delivery systems
Researchers from the Yong Loo Lin School of Medicine (NUS Medicine) have developed a groundbreaking way to engineer yeast (Saccharomyces cerevisiae) to create microbial communities that can perform complex tasks and self-regulate their composition in response to external signals. Source: Alexander Klepnev Baker’s yeast cells. Calcofluor ...
-
NewsThe secret of healthy aging may lie in our gut
A new study has revealed that gut bacteria may play a key role in aging, and that specific microbes could be targeted to promote healthy aging.
-
NewsMulti-omics strategy reveals how insect parasite fungus ameliorates sepsis-associated acute kidney injury
Scientists have found that Cordyceps sinensis significantly ameliorates renal injury and inflammation in sepsis-associated acute kidney injury (S-AKI) by regulating mitochondrial energy metabolism and macrophage polarization.
-
NewsResearchers discover new Candida auris – a possible global public health threat
Researchers have discovered a new clade (or type) of Candida auris, bringing the number of clades known globally to a total of six.
-
News$14.8 million grant supports Illinois-Singapore partnership on precision fermentation for food
The team has received a five-year, $14.8 million-dollar grant to develop the Centre for Precision Fermentation and Sustainability (PreFerS), focusing on enhancing the reliable, cost-effective production of safe, nutritious, and appetizing foods.