All Synthetic Biology articles
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NewsResearchers rebuild microscopic circadian clock that can control genes
Researchers have solved how the circadian clocks within microscopic bacteria are able to precisely control when different genes are turned on and off during the 24-hour cycle.
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NewsResearchers enable microorganisms to build molecules with light
Researchers are continually looking for new ways to hack the cellular machinery of microbes to make useful products. A new study shows they can expand the biosynthetic capabilities of these microbes by using light to help access new types of chemical transformations.
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NewsNew platform could develop vaccines faster than ever before
Scientists are optimizing a vaccine-development platform created to accelerate how quickly life-saving vaccines can be designed and deployed during infectious-disease outbreaks such as the COVID-19 pandemic.
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NewsResurrected ancient enzyme offers new window into early Earth and the search for life beyond it
By resurrecting a 3.2-billion-year-old enzyme and studying it inside living microbes, researchers have created a new way to improve our understanding of the origins of life on Earth. The study uses synthetic biology to reverse-engineer modern enzymes and rebuild their possible ancestors.
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NewsScientists synthesize medicarpin in baker’s yeast
Scientists have developed a way to synthesize medicarpin in yeast. Like palitaxel in the 1990s, this tumor-attacking sustance has only limited natural quantitites and is considered difficult to synthesize.
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NewsGame-changer for rare sugars: alkaline media unlocks high yield of rare sugars from bacteria
Bacterial EPSs (exopolysaccharides) are emerging as a sustainable source of rare sugars, offering advantages including higher yields and lower environmental impact.
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NewsFrom small experiments to big production: how constant impeller tip speed helps scale-up
Rhamnolipids (RL) are widely used in areas such as oil recovery and bioremediation, but their industrial production has long faced key challenges in the scale-up stage, including poor scalability and reproducibility.
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NewsScientists reprogramme E. coli to transform sugars into eco-friendly surfactant
A new study demonstrates a sustainable microbial strategy for producing lauryl glucoside by engineering a non-natural biosynthetic pathway in Escherichia coli, revealing precursor availability as a key bottleneck and moving towards greener biomanufacturing.
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NewsGolden Gate method enables rapid, fully-synthetic engineering of therapeutically relevant bacteriophages
Researchers have described the first fully synthetic bacteriophage engineering system for Pseudomonas aeruginosa. In this method, researchers engineer bacteriophages synthetically using sequence data rather than bacteriophage isolates.
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NewsBrewing a rare medicine: yeast engineered to produce a valuable astragalus isoflavonoid
By reconstructing the complete biosynthetic pathway inside Saccharomyces cerevisiae and systematically removing metabolic bottlenecks, researchers created the first yeast platform capable of producing calycosin-7-glucoside from simple carbon sources.
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NewsReconstructing nature’s oxindole factory: yeast-based biosynthesis of medicinal indole alkaloids
By identifying four key enzymes from a North American plant and reconstituting them in yeast, scientists have achieved complete de novo biosynthesis of complex oxindole molecules that are difficult to obtain from plants or chemical synthesis.
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NewsEngineering yeast to make rare anticancer saponins: reconstructing the complete biosynthesis of polyphyllin II
By combining plant transcriptomics, enzyme engineering, and synthetic biology, a new study demonstrates, for the first time, the full heterologous production of polyphyllin II in Saccharomyces cerevisiae.
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NewsScientists develop new biosynthetic route to optically pure S-2-Hydroxyisovalerate
By uncovering an unexpected enzyme activity and combining it with precise metabolic engineering, scientists has transformed Escherichia coli into a microbial factory capable of producing gram-per-liter levels of optically pure S-HIV from renewable carbon sources.
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NewsNot only toxic but also a nutrient: guanidine as a nitrogen source
Cyanobacteria are key ecological players of global carbon and nitrogen cycles. They are also becoming increasingly important for carbon-neutral biotechnology. They could serve as green cell factories for a light-driven and sustainable production of chemicals and fuels – a central pillar of the sustainable bioeconomy. Source: André Künzelmann/UFZ ...
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NewsResearchers deploy bacteria to make healthier sugar substitute
Researchers have developed a way to biosynthetically produce an otherwise rare sugar called tagatose, which could very well provide the sweetness and natural taste of table sugar without its potential harms. It might even provide some health benefits.
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NewsFrom palm oil to designer enzymes: researchers reprogram yeast cells
Many everyday products contain fatty acids from palm oil or coconut oil, but the extraction of these raw materials is associated with massive environmental issues. Researchers have now developed a biotechnological approach that could enable a more environmentally friendly production method.
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NewsEngineering oncolytic bacteria as precision cancer therapeutics
A new review summarizes recent advances in the design and application of synthetic biological strategies that enhance bacterial precision, safety, and efficacy in tumor therapy.
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NewsBacteria double as Trojan horse for artificial amino acids
Researchers have hijacked a natural transport system of the bacterium E. coli to develop a solution that allows artificial amino acids to be introduced into bacteria efficiently. This means the “amino acid toolbox” can be expanded for widespread use in medicine and the biotech industry.
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CareersSummer studentship: Lucy creates a synthetic microbiome to study mosquito-borne diseases at different life stages
Lucy Ella Malvern reports back on her AMI-sponsored summer studentship which investigated microbiome assembly in mosquitoes across developmental stages.
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NewsChemists synthesize a fungal compound that holds promise for treating brain cancer
For the first time, chemists have synthesized a fungal compound known as verticillin A, which was discovered more than 50 years ago and has shown potential as an anticancer agent.