All One Health Content – Page 134
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Scientists uncover cause of mysterious deaths of elephants in Zimbabwe
A bacterium, closely associated with deadly septicaemia, could have caused the deaths of six African elephants in Zimbabwe and possibly more in neighbouring countries. The findings place infectious diseases on the list of pressures on African elephants, whose populations continue to be under threat. During this ...
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Microbiome of fruit and vegetables positively influences diversity in the gut
In a meta-study, a research team has provided evidence that the consumption of fruit and vegetables contributes positively to bacterial diversity in the human gut.
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Boston Children’s Hospital receives a contract of up to $9 million to improve flu vaccines
The Precision Vaccines Program (PVP) at Boston Children’s Hospital has been awarded a contract from NIAID to develop a small molecule adjuvant to enhance the effectiveness of flu vaccines.
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Model can predict the evolution of new COVID variants
An international research team has developed a model that predicts the likely evolution of variants of the SARS-CoV-2 virus.
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Study shows engineered gut bacteria can treat hypertension
Scientists have proven that engineered bacteria can lower blood pressure, a finding that opens new doors in the pursuit of harnessing our body’s own microbiome to treat hypertension.
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Reduced activity of key enzyme linked to microcephaly in Zika-infected offspring
Researchers have shown that brain activity of Ndel1, an enzyme that plays an important role in neuron differentiation and migration, decreased in mice infected by Zika during pregnancy.
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Mosquito-controlling bacteria might also enhance insect fertility
A new study reveals biological mechanisms by which a specific strain of bacteria in the Wolbachia genus might enhance the fertility of the insects it infects - with potentially important implications for mosquito-control strategies.
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Probiotics delivered in biofilm state protect the intestines and brain in NEC model
Researchers have developed a novel probiotic system that harnesses the durability of biofilms to improve the administration of probiotics to patients.
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New hydrogel biomaterial mimics human tissue and fights bacteria
Scientists have created a new material, belonging to a family of substances called hydrogels, that could change the way human tissue can be grown in the lab and used in medical procedures.
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New advances in genomic surveillance tech could slow the spread of deadly ‘superbugs’
Harnessing new advances in genomic surveillance technology could help detect the rise of deadly ‘superbugs’ and slow their evolution and spread, improving global health outcomes, a new study suggests.
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Oxygen vacancy boosting Fenton reaction helps to fight bacterial infection in bone scaffold
A groundbreaking approach to address bacterial infection in artificial bone transplantation works by enriching H2O2 from the microenvironment and amplifying the ability of Fenton reaction to functionalize bone scaffold with antibacterial properties.
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Gut fungi trigger long-lasting severe COVID-19 immune response
Researchers have found that the growth of fungi in the intestinal tract, particularly strains of Candida albicans yeast, trigger an upsurge in immune cells whose actions can exacerbate lung damage.
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Lactate-producing bacteria inside tumors promote resistance to radiation therapy
Researchers have discovered that lactate-producing intratumoral bacteria drives resistance to radiation therapy, suggesting that lactic acid-producing bacteria present in various cancers may serve as novel therapeutic targets.
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Oral pathogen increases heart attack damage
Researchers have found that a periodontal pathogen, Porphyromonas gingivalis, inhibits autophagosome–lysosome fusion, and can therefore worsen cardiac remodeling and cause cardiac rupture after myocardial infarction.
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Study supports potential for injectable ‘chemical vaccine’ for malaria using atovaquone
Researchers demonstrate in mouse model that key mutation that renders malaria parasites resistant to atovaquone also makes them non-transmissible via mosquitoes.
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Broad-spectrum antiviral candidate targets dengue and SARS-CoV-2
A broad-spectrum antiviral drug candidate, 2-thiouridine, that targets positive-strand RNA viruses has been identified and characterized.
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Technique restores the function of a human cell surface protein in yeast cells
Scientists report a technique that could promote the use of yeast as a convenient platform to study human proteins and develop new drugs.
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Gut microbiota-derived 7-DHC tackles circadian rhythm disorders and IBD
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract categorized into ulcerative colitis and Crohn’s disease. Currently, aminosalicylates, glucocorticoids, immunomodulating drugs, and biological agents are common strategies for the treatment of IBD. The efficacy of these therapies is limited, however, and they are ...
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Potato supplement modifies gut microbiome, with implications for bone marrow transplants
Researchers at Baylor College of Medicine and the University of Michigan conducted a phase I pilot study to assess the feasibility of using potato starch as a dietary intervention to modify the gut microbiome in bone marrow transplant patients. The study, which appears in the journal Nature ...
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Antimicrobial peptides modulate lung injury by altering the intestinal microbiota
Researchers have identified a gut-lung axis driven by intestinal antimicrobial peptide expression and mediated by the intestinal microbiota that is linked to lung injury in newborns.