All Clostridioides difficile articles
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NewsStay or stray? Scientists discover why some gut microbes persist after fecal transplants
Scientists have identified why some gut microbes successfully stay in the gut after faecal transplants, whilst others are much more transient. They tracked key genetic features of gut bacteria in 86 healthy adults over the course of a year.
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NewsNew studies reveal how Clostridioides difficile behaves inside the body
Researchers studying C. diff at multiple levels, from how individual bacterial cells behave inside the gut to the molecular switches that help them survive and spread, are revealing hidden vulnerabilities.
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NewsGut health home-testing kit outcomes vary between kits and manufacturers
Results and health assessments from gut microbiome home-testing kits vary whether they are produced by the same or different manufacturers. The findings on testing kits from seven providers highlight the need for caution when interpreting or acting on test results, according to the authors.
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NewsPersonalized predictions of probiotic and prebiotic therapy success by computer models
A new study demonstrated that computer models of gut metabolism can predict which probiotics will successfully establish themselves in a person’s gut and how different prebiotics affect production of health-promoting short-chain fatty acids.
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NewsNovel vaccine protects against C. diff disease and recurrence
A novel vaccination approach cleared the harmful gut bacterium Clostridioides difficile in an animal model of infection. An experimental vaccine administered to the mucosal lining of the colon protected against illness, death, tissue damage and infection recurrence.
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NewsClostridioides difficile: A suspected pro-carcinogenic bacterium for gastrointestinal tumors
A new review proposes that C. difficile infection (CDI) may be a previously underappreciated pro-carcinogenic factor in CRC and possibly other gastrointestinal cancers, offering a fresh angle for research and prevention strategies.
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CareersScientific Event Travel Grant: how the Safepork conference surpassed my expectations
Shan Goh from the University of Hertfordshire reports back on the International Symposium on the Epidemiology and Control of Biological, Chemical and Physical Hazards in Pigs and Pork held in Rennes, France, in October. Shan was supported with a Scientific Event Travel Grant awarded by AMI.
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NewsStudy reveals promising gut-targeted therapy for C. difficile infections
Researchers have uncovered how the body’s bile acids bind to block C. diff’s most dangerous toxin. The research has informed the development of a new compound that can protect against C. diff in preclinical models, offering hope for safer, more effective treatments.
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NewsScientists develop a way to track donor bacteria after fecal microbiota transplants
Researchers have developed a new technology to track beneficial bacteria for up to 5 years after fecal microbiota transplants (FMT). The method allows scientists to distinguish even closely related bacterial strains and identify each one’s unique genetic “fingerprint.”
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NewsMap of bacterial gene interactions reveals potential drug targets
Researchers have developed a new technique called Dual transposon sequencing (Dual Tn-seq), which allows for rapid identification of genetic interactions. It maps how bacterial genes work together, revealing vulnerabilities that could be targeted by future antibiotics.
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NewsNew antibiotic to fight superbug C. diff proves effective in clinical trial
As the effectiveness of antibiotics meant to fight the deadly superbug Clostridioides difficile wanes, a research team is seeing positive results of a new antibiotic on the scene – ibezapolstat – which is proving successful in fighting these infectious bacteria in clinical trials.
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NewsDisarming a hidden killer: Predicting – and preventing – C. diff before it strikes
Researchers have developed a powerful, personalized modeling framework to predict whether Clostridioides difficile is likely to colonize an individual’s gut, and to test whether specific probiotic therapies might prevent and/or reverse that colonization.
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NewsProbiotics can help or hinder gut recovery after antibiotic treatment
All probiotics are not created equal, according to new research. In a mouse model, researchers found that different probiotic strains can either accelerate or delay the gut microbiome’s recovery after antibiotic treatment.
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NewsFiber consumption protects gut from serious bacterial infection, study suggests
Brazilian researchers have gained better understanding of the role of soluble dietary fibre in the mechanism of immune modulation and fight against gut pathogen Clostridioides difficile that causes severe diarrhoea and colon inflammation.
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NewsPartnering diet and intestinal microbes to protect against GI disease
New research suggests that we could get more out of our diets by harnessing intestinal microbes to break down plant compounds collectively known as phenolic glycosides. These compounds pair sugar molecules with a host of small molecules beneficial to human health.
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NewsC. diff uses toxic compound to fuel growth advantage
The pathogen C. diff — the most common cause of health care-associated infectious diarrhea — can use a compound that kills the human gut’s resident microbes to survive and grow, giving it a competitive advantage in the infected gut.
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NewsA review of Clostridioides difficile infection and treatments
<i>Clostridioides difficile</i> is a serious nosocomial infection that could cause from mild diarrhea to fatal colitis. Here presents a general overview that describes the current and emerging treatment practices for the prevention of <i>Clostridioides difficile</i> infection and its recourrences.
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NewsSynthetic microbiome therapy suppresses bacterial infection without antibiotics
A synthetic microbiome therapy, tested in mice, protects against severe symptoms of a gut infection that is notoriously difficult-to-treat and potentially life threatening in humans. Clostridioides difficile is a bacterium that can cause severe diarrhea, abdominal pain and colon inflammation.
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NewsExploring the impact of probiotics on gut microbiota disruption caused by antibiotics
In a new review, eight scientists comprehensively examined the evidence on using probiotics to restore the gut bacterial community during and after antibiotic treatment.
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NewsProbiotic delivers anticancer drug to the gut
Researchers have engineered a probiotic that delivers immunotherapy directly to the gut to shrink tumors in mice, offering a potentially promising oral drug for hard-to-reach cancers.