All Clostridioides difficile articles
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NewsNew antibiotic to fight superbug C. diff proves effective in clinical trial
As the effectiveness of antibiotics meant to fight the deadly superbug Clostridioides difficile wanes, a research team is seeing positive results of a new antibiotic on the scene – ibezapolstat – which is proving successful in fighting these infectious bacteria in clinical trials.
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NewsDisarming a hidden killer: Predicting – and preventing – C. diff before it strikes
Researchers have developed a powerful, personalized modeling framework to predict whether Clostridioides difficile is likely to colonize an individual’s gut, and to test whether specific probiotic therapies might prevent and/or reverse that colonization.
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NewsProbiotics can help or hinder gut recovery after antibiotic treatment
All probiotics are not created equal, according to new research. In a mouse model, researchers found that different probiotic strains can either accelerate or delay the gut microbiome’s recovery after antibiotic treatment.
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NewsFiber consumption protects gut from serious bacterial infection, study suggests
Brazilian researchers have gained better understanding of the role of soluble dietary fibre in the mechanism of immune modulation and fight against gut pathogen Clostridioides difficile that causes severe diarrhoea and colon inflammation.
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NewsPartnering diet and intestinal microbes to protect against GI disease
New research suggests that we could get more out of our diets by harnessing intestinal microbes to break down plant compounds collectively known as phenolic glycosides. These compounds pair sugar molecules with a host of small molecules beneficial to human health.
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NewsC. diff uses toxic compound to fuel growth advantage
The pathogen C. diff — the most common cause of health care-associated infectious diarrhea — can use a compound that kills the human gut’s resident microbes to survive and grow, giving it a competitive advantage in the infected gut.
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NewsA review of Clostridioides difficile infection and treatments
<i>Clostridioides difficile</i> is a serious nosocomial infection that could cause from mild diarrhea to fatal colitis. Here presents a general overview that describes the current and emerging treatment practices for the prevention of <i>Clostridioides difficile</i> infection and its recourrences.
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NewsSynthetic microbiome therapy suppresses bacterial infection without antibiotics
A synthetic microbiome therapy, tested in mice, protects against severe symptoms of a gut infection that is notoriously difficult-to-treat and potentially life threatening in humans. Clostridioides difficile is a bacterium that can cause severe diarrhea, abdominal pain and colon inflammation.
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NewsExploring the impact of probiotics on gut microbiota disruption caused by antibiotics
In a new review, eight scientists comprehensively examined the evidence on using probiotics to restore the gut bacterial community during and after antibiotic treatment.
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NewsProbiotic delivers anticancer drug to the gut
Researchers have engineered a probiotic that delivers immunotherapy directly to the gut to shrink tumors in mice, offering a potentially promising oral drug for hard-to-reach cancers.
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NewsNew evidence links gut microbiome to chronic disease outcomes
A new review consolidates recent findings that demonstrate a causal role for the gut microbiome in the progression of multiple diseases, ranging from gastrointestinal conditions to immune-related and psychiatric disorders.
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NewsStudy expands understanding of how fecal microbiota transplants may work to restore gut health
In a novel study that identified male chromosome genetic material in the intestines of female patients undergoing fecal transplants, researchers say they have significantly expanded scientific understanding of how some of these transplants may succeed and work.
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NewsResearchers hope to develop novel drugs for gastrointestinal disorders by fermenting feces
In a new study, researchers have been cultivating ‘good viruses’ from feces. The goal is to replace fecal capsules now being used in so-called fecal transplants and improve this life-saving treatment through standardization.
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NewsmRNA vaccine created to prevent and treat C. difficile
The vaccine is the first mRNA vaccine against C. difficile and would be the first vaccine in general to successfully ward off the bacterial infection.
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NewsLachnospiraceae could be key to successful fecal transplants
Fecal microbiota transplants are a magic bullet for patients with recurring infections from Clostridioides difficile (C. diff), but researchers are only beginning to understand why.
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NewsHospitals that are understaffed for infection prevention and control have higher rates of infection, study says
Inadequate infection prevention and control staffing levels are associated with higher rates of healthcare-associated infections, according to a new study published today in the American Journal of Infection Control. The study, conducted by the APIC Center for Research, Practice & Innovation, summarizes a pilot project to evaluate ...
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News Scientists discover superbug’s rapid path to antibiotic resistance
Researchers have discovered how a hospital superbug Clostridioides difficile (C.diff) can rapidly evolve resistance to vancomycin. In less than two months the bacteria could develop resistance to 32 times the initial antibiotic concentration.
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NewsStudy identifies protein that affects health of gut microbiota and response to bacterial infection
A new study shows how the presence of a specific protein called IL-22BP affects the composition of the gut microbiota and the body’s response to bacterial infection.
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CareersA conversation at the forefront of human microbiome research
Yang Yue and Professor Alan Walker discuss everything from precision medicine and the omics approach, to challenges in the road ahead and the future of microbiome research.
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NewsDiagnostic stewardship approach to C. diff reduces unnecessary testing
Revised rules for when Clostridioides difficile tests could be ordered helped to reduce inappropriate testing by 20%, which in turn can help rein in the overtreatment of patients.