All Clostridioides difficile articles
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NewsQ&A: Meet Letters in Applied Microbiology Junior Reviewer Md. Ekramul Karim
We caught up with Md Ekramul Karim, a Ph.D. candidate at the University of Houston, who is one of the newest Junior Reviewers with Letters in Applied Microbiology.
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NewsEngineered gut bacteria therapy emerges as scalable potential alternative to fecal microbiota transplants following clinical trial
Researchers have developed a new manufacturing platform for producing targeted mixtures of beneficial gut bacteria, an approach that could help expand access to microbiome-based therapies for patients with recurrent Clostridioides difficile (C. difficile) infection.
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NewsPost-discharge antibiotics may offer limited benefit after pediatric appendicitis
Acute appendicitis is one of the most common surgical emergencies among children, and complicated acute appendicitis (CAA), including perforated or gangrenous disease, carries a higher risk of infection and longer hospitalization. While intravenous antibiotics during hospitalization are standard practice, the role of oral home antibiotics (OHA) after discharge remains controversial. ...
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News To thwart pathogens, researchers are giving beneficial microbes what they really want
Researchers have developed a new method that allows precise modification of any microbiome with prebiotics, helping beneficial organisms outcompete dangerous pathogens.
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NewsNovel treatment protocol targets the deadliest cases of C. difficile infection
A new study demonstrated that fecal microbiota transplantation (FMT) can rapidly reverse systemic inflammation and improve survival in patients with fulminant Clostridioides difficile infection.
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NewsStay or stray? Scientists discover why some gut microbes persist after fecal transplants
Scientists have identified why some gut microbes successfully stay in the gut after faecal transplants, whilst others are much more transient. They tracked key genetic features of gut bacteria in 86 healthy adults over the course of a year.
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NewsNew studies reveal how Clostridioides difficile behaves inside the body
Researchers studying C. diff at multiple levels, from how individual bacterial cells behave inside the gut to the molecular switches that help them survive and spread, are revealing hidden vulnerabilities.
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NewsGut health home-testing kit outcomes vary between kits and manufacturers
Results and health assessments from gut microbiome home-testing kits vary whether they are produced by the same or different manufacturers. The findings on testing kits from seven providers highlight the need for caution when interpreting or acting on test results, according to the authors.
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NewsPersonalized predictions of probiotic and prebiotic therapy success by computer models
A new study demonstrated that computer models of gut metabolism can predict which probiotics will successfully establish themselves in a person’s gut and how different prebiotics affect production of health-promoting short-chain fatty acids.
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NewsNovel vaccine protects against C. diff disease and recurrence
A novel vaccination approach cleared the harmful gut bacterium Clostridioides difficile in an animal model of infection. An experimental vaccine administered to the mucosal lining of the colon protected against illness, death, tissue damage and infection recurrence.
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NewsClostridioides difficile: A suspected pro-carcinogenic bacterium for gastrointestinal tumors
A new review proposes that C. difficile infection (CDI) may be a previously underappreciated pro-carcinogenic factor in CRC and possibly other gastrointestinal cancers, offering a fresh angle for research and prevention strategies.
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CareersScientific Event Travel Grant: how the Safepork conference surpassed my expectations
Shan Goh from the University of Hertfordshire reports back on the International Symposium on the Epidemiology and Control of Biological, Chemical and Physical Hazards in Pigs and Pork held in Rennes, France, in October. Shan was supported with a Scientific Event Travel Grant awarded by AMI.
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NewsStudy reveals promising gut-targeted therapy for C. difficile infections
Researchers have uncovered how the body’s bile acids bind to block C. diff’s most dangerous toxin. The research has informed the development of a new compound that can protect against C. diff in preclinical models, offering hope for safer, more effective treatments.
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NewsScientists develop a way to track donor bacteria after fecal microbiota transplants
Researchers have developed a new technology to track beneficial bacteria for up to 5 years after fecal microbiota transplants (FMT). The method allows scientists to distinguish even closely related bacterial strains and identify each one’s unique genetic “fingerprint.”
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NewsMap of bacterial gene interactions reveals potential drug targets
Researchers have developed a new technique called Dual transposon sequencing (Dual Tn-seq), which allows for rapid identification of genetic interactions. It maps how bacterial genes work together, revealing vulnerabilities that could be targeted by future antibiotics.
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NewsNew antibiotic to fight superbug C. diff proves effective in clinical trial
As the effectiveness of antibiotics meant to fight the deadly superbug Clostridioides difficile wanes, a research team is seeing positive results of a new antibiotic on the scene – ibezapolstat – which is proving successful in fighting these infectious bacteria in clinical trials.
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NewsDisarming a hidden killer: Predicting – and preventing – C. diff before it strikes
Researchers have developed a powerful, personalized modeling framework to predict whether Clostridioides difficile is likely to colonize an individual’s gut, and to test whether specific probiotic therapies might prevent and/or reverse that colonization.
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NewsProbiotics can help or hinder gut recovery after antibiotic treatment
All probiotics are not created equal, according to new research. In a mouse model, researchers found that different probiotic strains can either accelerate or delay the gut microbiome’s recovery after antibiotic treatment.
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NewsFiber consumption protects gut from serious bacterial infection, study suggests
Brazilian researchers have gained better understanding of the role of soluble dietary fibre in the mechanism of immune modulation and fight against gut pathogen Clostridioides difficile that causes severe diarrhoea and colon inflammation.
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NewsPartnering diet and intestinal microbes to protect against GI disease
New research suggests that we could get more out of our diets by harnessing intestinal microbes to break down plant compounds collectively known as phenolic glycosides. These compounds pair sugar molecules with a host of small molecules beneficial to human health.