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Pediatric investigation review discusses the challenges, innovations, and future directions in dengue vaccine development
A new review discusses the current status and implications of dengue vaccines like CYD-TDV, TAK-003, and Butantan-DV while exploring the challenges in Dengue vaccine development like ADE, and proposes future directions in this field.
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Researchers reveal core cellular network modulating immune phenotype switching in hepatitis B
A new study explores the immune dynamics across different phases of HBV infection, including acute hepatitis B, immune tolerance, immune activation, and inactive chronic infection, using single-cell RNA and TCR/BCR sequencing.
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Chiral phytovirucide targets viral Nia protein to inhibit proliferation
A new study focuses on the search for small molecules to target the Nia protein of Potato virus Y (PVY), one of the most economically destructive viruses affecting Solanaceous crops such as potatoes, peppers, and tomatoes.
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Researchers reveal how human genetics and intratumoral microbiota affect colorectal cancer
A study shows that the single-nucleotide polymorphism (SNP) rs2355016—a tiny DNA change that some people carry—affects how intratumoral microbiota adhere to tumor cells, promoting colorectal cancer progression.
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Broader antibiotic use could change the course of cholera outbreaks, research suggests
Disease modeling research suggests that, for some cholera outbreaks, prescribing antibiotics more aggressively could slow or stop the spread of the disease and even reduce the likelihood of antibiotic resistance.
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National-level actions effective at tackling antibiotic resistance
National-level policies can reduce the impact of antibiotic resistance across diverse countries, according to a new study. The comparison of countries found that national action was consistently associated with improved indicators of antibiotic resistance.
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Fungi dwelling on human skin may provide new antibiotics
Researchers have uncovered a molecule produced by yeast living on human skin that showed potent antimicrobial properties against a pathogen responsible for a half-million hospitalizations annually in the United States.
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A hidden control center: How bacteria regulate their attack strategies
Researchers have discovered that a key bacterial protein, CsrA, gathers in a droplet-like structure inside cells to control when and how bacteria activate their disease-causing genes.
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Human protein HSF2 helps wake up sleeping cancer-linked viruses
A new study demonstrates the ability of the human protein HSF2 to remodel the viral DNA to enable the transition from dormant viral latency to active lytic reactivation.
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COVID-19 vaccinations are metabolically safe, research finds
New research confirms that multiple doses of COVID-19 vaccines do not cause significant metabolic changes, offering reassurance for those concerned about potential long-term side effects of vaccination.
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Now is the time to strengthen infection prevention and control (IPC) programs in healthcare facilities
A joint position paper urges United States healthcare facilities to elevate the standards and effectiveness of their Infection Prevention and Control (IPC) programs.
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How math helps to protect crops from invasive disease
New research demonstrates how mathematical modeling can predict outbreaks of toxic fungi in Texas corn crops—offering a potential lifeline to farmers facing billions in harvest losses.
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Measles may be making a comeback in the US, research finds
If immunization rates drop further over a prolonged period of time, measles and even other wiped-out diseases — such as rubella and polio — could one day make a comeback in the United States, according to a new study.
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Bacteria’s mysterious viruses can fan flames of antibiotic damage, according to new model
Researchers built a model that allows them to diminish phage communities from a mouse gut microbiome — and then bring them back — without affecting the bacteria. A test run found evidence that phages may increase gut bacteria’s sensitivity to antibiotics.
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Global virus network issues urgent call to action to mitigate the rising threat of H5N1 avian influenza
The Global Virus Network (GVN) has issued a call-to-action, calling on world governments to address the threat of H5N1 avian influenza by enhancing surveillance, implementing biosecurity measures, and preparing for potential human-to-human transmission.
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Every dose counts: Safeguarding the success of vaccination in Europe
Marking European Immunization Week (EIW) 2025, a new report highlights the risks of suboptimal vaccination coverage in Europe and publishes a set of operational tools that public health authorities can use to improve vaccination acceptance and uptake.
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Influenza virus hacks cell’s internal system
The influenza virus manipulates the body’s gene regulation system to accelerate its own spread, according to researchers. Their study shows that an already approved drug could help strengthen immune defenses—though its effect in humans remains to be confirmed.
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Antibiotic resistance: Towards drugs to disarm bacteria
Researchers have identified the mutation frequency decline (Mfd) protein, a virulence factor produced by all bacteria and essential for them to resist the host immune system. This protein has the additional function of promoting spontaneous and random mutations.
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European Immunization Week 2025: Inequalities in immunisation against measles could contribute to outbreaks
Research reveals inequalities in MMR vaccination that may contribute to measles outbreaks and epidemics, emphasising the importance of socioeconomic and demographic data in driving public health efforts.
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Updated recommendations to prevent infections through effective sterilization and high-level disinfection of reusable medical devices
New comprehensive guidance has been released in the US to help healthcare facilities prevent the transmission of infections through improved practices in sterilization and high-level disinfection (HLD) of reusable medical devices.