All Mycobacterium tuberculosis articles
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NewsNovel biosensing platform enables fingertip blood-based micro-volume t-cell immune monitoring
A new platform, known as Tip Optofluidic Immunoassay Interferon-Gamma Release Assay (TOI-IGRA), could revolutionize how people monitor their immune health. The platform allows for the precise quantification of pathogen-specific T-cell responses using a mere 15-25 μL of fingertip blood.
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NewsStudy maps how tuberculosis bacteria power themselves
A new study provides the first detailed 3D structure of a protein called EtfD, which the bacterium Mycobacterium tuberculosis uses to extract energy from lipids (fats), along with the first laboratory test capable of directly measuring its activity.
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NewsEmerging class of antibiotics to tackle global tuberculosis crisis
Researchers investigated how three naturally occurring antibiotic compounds – ecumicin, ilamycin and cyclomarin – act on a vital protein degradation machine inside Mycobacterium tuberculosis, the bacterium that causes TB.
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NewsFirst evidence of fungal pathogen becoming more deadly when co-infected with tuberculosis
Co-infection of Mycobacterium tuberculosis, together with Cryptococcus neoformans, is a grave public health concern, increasing the risk of death significantly. Researchers have found that in the presence of Mycobacteria, the fungus changed its cell density, cell diversity, and capsule size.
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NewsResearchers develop new inhalable treatment for TB
Researchers have developed an inhalable, immunomodulating, biocompatible nanoparticle system encapsulating rifampin, one of the most important TB drugs.
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NewsHow Mtb safeguards itself from foreign DNA
Researchers have discovered how a key protein in the tuberculosis bacterium helps protect it from the influence of foreign DNA inserted into its genome. Understanding how this protein – called Lsr2 – functions could help develop drugs that target it, thereby aiding in the fight against TB.
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NewsNew test shows which antibiotics actually work
Drugs that act against bacteria are mainly assessed based on how well they inhibit bacterial growth under laboratory conditions. A critical factor is whether the active substances actually kill the pathogens in the body. Researchers have presented a new method for measuring how effectively antibiotics kill bacteria.
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NewsTB harnesses part of immune defense system to cause infection
Scientists have made a discovery that helps explain why humans and animals are so susceptible to contracting tuberculosis – and it involves the bacteria harnessing part of the immune system meant to protect against infection. They team discovered that MTB survives within the cells of its host by targeting Dectin-1.
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NewsNew clinical standards strengthen antimicrobial stewardship in tuberculosis care
An international panel of experts from 32 countries has presented specific antimicrobial stewardship standards for TB care for the first time.
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NewsTuberculosis: Scientists develop novel drug candidate for combating resistant pathogens
Researchers have developed a promising new substance for targeting bacteria that cause tuberculosis. The team have produced a compound that inhibits the pathogens’ ability to produce energy and causes them to die.
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NewsBlood-based immunological signatures for extrapulmonary tuberculosis decoded
Scientists have deciphered the immunological properties of extrapulmonary tuberculosis (EPTB) in the blood of affected patients. The results may help to develop new targeted treatments and tests for this important disease.
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NewsScientists uncover tuberculosis bacterium’s ’heartbeat’, opening door to new treatments
Scientists have identified a molecular system inside Mycobacterium tuberculosis that functions like the organism’s heart or lungs, keeping it alive. The system, known as PrrAB, helps the bacterium generate energy and breathe. When researchers used a gene-silencing tool, the bacterium died.
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NewsNew study finds targets for a new tuberculosis vaccine
A large-scale screen of tuberculosis proteins has revealed several possible antigens that could be developed as a new vaccine for TB, the world’s deadliest infectious disease.
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NewsResearchers discover method to combat antibiotic treatment failure
Researchers explored ways to alter our own immune cells to help antibiotics work more effectively. They identified a small molecule that alters the body’s immune cells, forcing them to ’wake up’ dormant bacteria and make them more vulnerable to antibiotic treatment.
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NewsCould targeted steroid use offer a universal complimentary treatment to fight TB?
Newly published research provides evidence that treating patients with steroids may enhance the function of their macrophages to kill the mycobacteria, while diminishing pathways of inflammatory damage.
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NewsRare bacterium ‘plays dead’ to evade detection in NASA clean rooms
A rare novel bacterium found in an unexpected environment may be evading detection by “playing dead”. Discovered in NASA spacecraft assembly clean rooms, Tersicoccus phoenicis could have major implications for planetary protection and clean room sterilization practices.
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NewsTuberculosis vulnerability of people with HIV: a viral protein implicated
Tuberculosis accounts for one in three deaths among people living with HIV. A new study highlights the key role played by Tat 2 – a viral protein secreted by HIV-infected cells – in this hyper-vulnerability phenomenon.
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NewsNew ‘cough simulator’ mimics TB transmission with unprecedented accuracy
Researchers have developed a new experimental system called Transmission Simulation System (TSS) that replicates the airborne transmission of TB – by simulating the human cough – with unparalleled realism and never-before-seen precision.
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OpinionSafety and nutritional claims for raw milk
Robert F Kennedy Jr. famously advocates drinking raw milk and promotes its benefits. But how safe is unpasteurised milk? Nicola Holden and Gil Domingue, who sit on Applied Microbiology International’s Food Security Scientific Advisory Group, take a deep dive into the science.
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NewsSeventy-year-old Parkinson’s drug shows promise against tuberculosis
A medication developed in the 1950s to treat Parkinson’s disease may offer a powerful new tool in the fight against tuberculosis. The study found that benztropine can dramatically reduce levels of TB-causing bacteria by boosting the body’s natural immune response.