All Mycobacterium tuberculosis articles
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Researchers reveals why recombinant BCG induces a stronger and longer-lasting response
Researchers are working on a more potent version of the BCG vaccine that protects against TB. While the conventional immunizer reduced infection by 90% in experiments with mice, the recombinant BCG increased protection rates to 99%.
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Novel 3D hydrogel culture to study TB infection and treatment
Researchers have designed a novel 3D hydrogel culture system that mimics the mammalian lung environment, providing a platform to track and study how tuberculosis bacteria infect lung cells and test the efficacy of therapeutics used to treat TB.
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Recombinant protein offers potential as TB booster vaccine
No new vaccine has yet surpassed BCG, which is a highly effective live vaccine and is very effective in preventing tuberculosis in children. Creating a booster vaccine to strengthen immunity in adults is considered a promising and realistic option.
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Undernourished household members at increased risk for developing TB after exposure
Researchers have found that undernourished household contacts are three times more likely to progress to TB disease.
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Researchers uncover new reasons to target neutrophils for tuberculosis therapy
Using cell models of infection, scientists examined the cross-talk between two lung immune cells: the macrophage and the neutrophil.
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UC San Diego donates blood samples to accelerate Actiphage TB diagnostic study
Sharing samples from a previous study will help to accelerate the development of a blood-based phage diagnostic for tuberculosis. PBD Biotech has asked if more researchers would be prepared to contribute samples they no longer require to help end TB.
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New classification of tuberculosis supports efforts to eliminate the disease
A new way to classify tuberculosis (TB) that aims to improve focus on the early stages of the disease has been presented by an international team.
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Tuberculosis bacteria present in 90% of those with symptoms - including those who test negative
Mycobacterium tuberculosis (Mtb) is present in exhaled breath of 90% of those presenting with suspected tuberculosis. This includes those who were negative on conventional sputum testing and not diagnosed with TB.
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Drug-resistant tuberculosis responds rapidly to bedaquiline-based second-line therapy
Patients who have drug-resistant tuberculosis (TB) have a similar microbiological response to bedaquiline-based second-line medications as patients with drug-sensitive TB taking first-line regimens.
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Exposure to Mycobacterium seems to remodel immune response against TB
A collaborative team has uncovered how prior exposure to bacteria changes the lung’s innate immune response - and what it might mean for vaccines.
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People in prison are at very high risk of tuberculosis, even years after release
A study in Paraguay evaluates tuberculosis incidence during and after incarceration in a cohort of nearly 3,000 people.
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New antibiotics make TB bacterium less pathogenic for humans
Researchers have identified new, antibiotic molecules that target Mycobacterium tuberculosis and make it less pathogenic for humans.
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Single gene could be crucial for persistence in TB bacteria
Researchers have uncovered an important mechanism that allows the tuberculosis (TB) bacterium to persist in the human host for decades.
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Nanoparticles with antibacterial action shorten duration of tuberculosis treatment
A low-cost technology involving nanoparticles loaded with antibiotics and other antimicrobial compounds that can be used in multiple attacks on infections by the bacterium responsible for most cases of tuberculosis has been developed.
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Novel compounds promise success in the fight against tuberculosis and depression
Scientists have shown that a specific polyprenylated polycyclic acylphloroglucinol, PPAP53, is able to activate human macrophages to fight resistant tuberculosis bacteria without being toxic to the macrophages themselves.
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NIH clinical trial of tuberculous meningitis drug regimen begins
A trial of a new drug regimen to treat tuberculous meningitis (TBM) has started enrolling adults and adolescents in several countries where tuberculosis (TB) is prevalent.
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Drug-resistant tuberculosis may be under-diagnosed, reveals genomic analysis
This genomic sequencing study, in southern Mozambique, is the first to characterise the drug resistance profile at the population level and identify mutations that escape routine diagnostic tests.
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Blood glycerol levels linked to tuberculosis severity in Type 2 Diabetes
A study has uncovered that elevated glycerol levels are responsible for increased severity of tuberculosis (TB) disease in experimental models with Type 2 diabetes (T2D).
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Researchers develop a new TB vaccine testing model by leveraging old BCG vaccine
Each year, tuberculosis (TB) kills more people than any other infectious disease, falling out of the top spot only temporarily during the COVID-19 pandemic. Source: Saint Louis University Daniel Hoft, M.D., Ph.D., director of the Saint Louis University Center for Vaccine Development Despite TB’s wide reach and ...
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Potential therapeutic target found to combat TB, a disrupted NAD(H) homeostasis
A study shows how Mycobacterium tuberculosis perturbs homeostasis of the high-energy molecule NADH and reprograms glycolysis in myeloid cells - highlighting glycolysis as a potential therapeutic target.