All Mycobacterium tuberculosis articles
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NewsSusceptibility to bovine TB in cattle traced to key genes
A new study identifying genetic factors contributing to bovine tuberculosis (bTB) susceptibility has found several key genes and pathways involved in the bovine response to Mycobacterium bovis, the causative agent of the disease in cattle.
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NewsFour advances that could change tuberculosis treatment
World Tuberculosis Day commemorates Robert Koch’s discovery of the source bacterium Mycobacterium tuberculosis. Scientists are still refining TB diagnosis methods and treatment strategies - some of the latest innovations are revealed here.
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NewsTB vaccine candidate provides ‘elite’ protection
A tuberculosis vaccine candidate under development shows complete protection and superior immune response in nonhuman primates compared to the existing BCG vaccine.
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NewsDesigning self-destructing bacteria to make effective tuberculosis vaccines
Preclinical studies have demonstrated a more effective tuberculosis (TB) vaccine through engineering bacteria to self-destruct and swiftly stops the infection on cue, which activates a more robust immune response.
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NewsNovel antibiotic BTZ-043 also reaches tuberculosis bacteria hiding in dead lung tissue
Researchers have shown that the novel antibiotic BTZ-043 effectively penetrates tubercolous lesions and accumulates there in high concentrations. Consequently, the drug can fight Mtb bacteria even in hard-to-reach areas.
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NewsAI accelerates the search for new tuberculosis drug targets
A novel biotechnology was developed to utilize artificial intelligence (AI) as a high-throughput way to identify more effective antimicrobial candidates to treat the multi-drug resistant Mycobacterium tuberculosis and understand their underlying modes of action.
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NewsSelf-destructing vaccine offers enhanced protection against tuberculosis in monkeys
A self-destructing vaccine administered intravenously provides additional safety and protection against tuberculosis (TB) in macaque monkeys, suggests new research.
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NewsTuberculosis strains resistant to new drugs are transmitted between patients
Researchers have identified 514 Mycobacterium tuberculosis strains that are resistant to TB drugs, including both old and new treatment regimens, in 27 countries across four continents. 28% of these strains were transmitted directly from one patient to another.
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NewsSystem to auto-detect new variants will inform better response to future infectious disease outbreaks
Researchers have come up with a new way to identify more infectious variants of viruses or bacteria that start spreading in humans - including those causing flu, COVID, whooping cough and tuberculosis.
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NewsPeat-bog fungi produce substances that kill tuberculosis-causing bacteria
An analysis of fungi collected from peat bogs has identified several species that produce substances toxic to the bacterium that causes the human disease tuberculosis.
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NewsResearchers reveal why a key tuberculosis drug works against resistant strains
Research has uncovered why a relatively new antibiotic for tuberculosis (TB) works against multidrug-resistant strains, potentially inspiring improved treatments and drug development strategies.
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NewsStudy identifies ‘Achilles heel’ of drug-resistant pathogens
A study has found a highly vulnerable weakness in drug-resistant Mycobacterium tuberculosis, using a genetic platform to identify biological pathways in a drug-resistant strain of the bacterium that are highly sensitive to inhibition.
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NewsStudy identifies potential novel drug to treat tuberculosis
A new study demonstrates that a novel semi-synthetic compound can be derived from natural compounds to produce potent activity against Mycobacterium tuberculosis, including multi-drug resistant strains.
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NewsPlant compound used in traditional medicine may help fight tuberculosis
A compound found in African wormwood — a plant used medicinally for thousands of years to treat many types of illness — could be effective against tuberculosis, according to a new study.
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NewsResearchers discover mechanism driving immune perturbations after severe TB infections
Rsearchers have discovered a mechanism that drives the long-term decline in immune response that is observed after tuberculosis (TB) has been successfully treated.
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NewsMarine sponge microbe provides insights into the evolution of tuberculosis
The surprising discovery of a bacterium in a marine sponge from the Great Barrier Reef with striking similarity to the pathogen responsible for tuberculosis (TB) could unlock and inform future TB research and treatment strategies.
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NewsNew findings on TB could change how we treat inflammatory disorders
Researchers have found rare mutation that leaves its carriers much more likely to become ill with TB—but, curiously, not with other infectious diseases, potentially upending long-held assumptions about the immune system.
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NewsSuper cally molecules take down tuberculosis
Researchers have identified and synthesised a group of molecules that can act against the cause of tuberculosis in a new way. The callyaerins act against TB by employing a fundamentally different mechanism compared to antibiotic agents used to date.
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NewsResearchers reveals why recombinant BCG induces a stronger and longer-lasting response
Researchers are working on a more potent version of the BCG vaccine that protects against TB. While the conventional immunizer reduced infection by 90% in experiments with mice, the recombinant BCG increased protection rates to 99%.
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NewsNovel 3D hydrogel culture to study TB infection and treatment
Researchers have designed a novel 3D hydrogel culture system that mimics the mammalian lung environment, providing a platform to track and study how tuberculosis bacteria infect lung cells and test the efficacy of therapeutics used to treat TB.