All Mycobacterium tuberculosis articles
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NewsMarine sponge microbe provides insights into the evolution of tuberculosis
The surprising discovery of a bacterium in a marine sponge from the Great Barrier Reef with striking similarity to the pathogen responsible for tuberculosis (TB) could unlock and inform future TB research and treatment strategies.
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NewsNew findings on TB could change how we treat inflammatory disorders
Researchers have found rare mutation that leaves its carriers much more likely to become ill with TB—but, curiously, not with other infectious diseases, potentially upending long-held assumptions about the immune system.
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NewsSuper cally molecules take down tuberculosis
Researchers have identified and synthesised a group of molecules that can act against the cause of tuberculosis in a new way. The callyaerins act against TB by employing a fundamentally different mechanism compared to antibiotic agents used to date.
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NewsResearchers reveals why recombinant BCG induces a stronger and longer-lasting response
Researchers are working on a more potent version of the BCG vaccine that protects against TB. While the conventional immunizer reduced infection by 90% in experiments with mice, the recombinant BCG increased protection rates to 99%.
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NewsNovel 3D hydrogel culture to study TB infection and treatment
Researchers have designed a novel 3D hydrogel culture system that mimics the mammalian lung environment, providing a platform to track and study how tuberculosis bacteria infect lung cells and test the efficacy of therapeutics used to treat TB.
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NewsRecombinant protein offers potential as TB booster vaccine
No new vaccine has yet surpassed BCG, which is a highly effective live vaccine and is very effective in preventing tuberculosis in children. Creating a booster vaccine to strengthen immunity in adults is considered a promising and realistic option.
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NewsUndernourished household members at increased risk for developing TB after exposure
Researchers have found that undernourished household contacts are three times more likely to progress to TB disease.
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NewsResearchers uncover new reasons to target neutrophils for tuberculosis therapy
Using cell models of infection, scientists examined the cross-talk between two lung immune cells: the macrophage and the neutrophil.
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NewsUC San Diego donates blood samples to accelerate Actiphage TB diagnostic study
Sharing samples from a previous study will help to accelerate the development of a blood-based phage diagnostic for tuberculosis. PBD Biotech has asked if more researchers would be prepared to contribute samples they no longer require to help end TB.
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NewsNew classification of tuberculosis supports efforts to eliminate the disease
A new way to classify tuberculosis (TB) that aims to improve focus on the early stages of the disease has been presented by an international team.
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NewsTuberculosis bacteria present in 90% of those with symptoms - including those who test negative
Mycobacterium tuberculosis (Mtb) is present in exhaled breath of 90% of those presenting with suspected tuberculosis. This includes those who were negative on conventional sputum testing and not diagnosed with TB.
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NewsDrug-resistant tuberculosis responds rapidly to bedaquiline-based second-line therapy
Patients who have drug-resistant tuberculosis (TB) have a similar microbiological response to bedaquiline-based second-line medications as patients with drug-sensitive TB taking first-line regimens.
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NewsExposure to Mycobacterium seems to remodel immune response against TB
A collaborative team has uncovered how prior exposure to bacteria changes the lung’s innate immune response - and what it might mean for vaccines.
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NewsPeople in prison are at very high risk of tuberculosis, even years after release
A study in Paraguay evaluates tuberculosis incidence during and after incarceration in a cohort of nearly 3,000 people.
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NewsNew antibiotics make TB bacterium less pathogenic for humans
Researchers have identified new, antibiotic molecules that target Mycobacterium tuberculosis and make it less pathogenic for humans.
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NewsSingle gene could be crucial for persistence in TB bacteria
Researchers have uncovered an important mechanism that allows the tuberculosis (TB) bacterium to persist in the human host for decades.
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NewsNanoparticles with antibacterial action shorten duration of tuberculosis treatment
A low-cost technology involving nanoparticles loaded with antibiotics and other antimicrobial compounds that can be used in multiple attacks on infections by the bacterium responsible for most cases of tuberculosis has been developed.
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NewsNovel compounds promise success in the fight against tuberculosis and depression
Scientists have shown that a specific polyprenylated polycyclic acylphloroglucinol, PPAP53, is able to activate human macrophages to fight resistant tuberculosis bacteria without being toxic to the macrophages themselves.
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NewsNIH clinical trial of tuberculous meningitis drug regimen begins
A trial of a new drug regimen to treat tuberculous meningitis (TBM) has started enrolling adults and adolescents in several countries where tuberculosis (TB) is prevalent.
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NewsDrug-resistant tuberculosis may be under-diagnosed, reveals genomic analysis
This genomic sequencing study, in southern Mozambique, is the first to characterise the drug resistance profile at the population level and identify mutations that escape routine diagnostic tests.
