All Paxlovid articles
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NewsStudy of oral azvudine versus nirmatrelvir/ritonavir in elderly hospitalized COVID-19 patients
A study used five analytical methods to show that oral azvudine has a therapeutic effect in elderly COVID-19 patients aged over 60 years.
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NewsNew COVID-19 drug shows greater promise against resistant viral strains
A new standalone oral drug candidate has proven to be effective against Paxlovid-resistant COVID-19 strain in animal models. It works with low doses and cause no drug interaction-induced side effects.
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NewsPaxlovid’s impact on hospitalization and death in COVID-vaccinated older adults far weaker than previously thought
A new study overturns the assumption that Paxlovid’s effectiveness in reducing COVID-19 hospitalizations and deaths in unvaccinated adults also applies to vaccinated adults.
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NewsA new class of antivirals could help prevent future pandemics
A new study introduces a proof-of-concept for a novel class of antivirals that would target a type of enzyme essential not just to SARS, but also many RNA viruses, including Ebola and dengue, as well as cytosolic-replicating DNA viruses, including Pox viruses.
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NewsScientists assess efficacy of clinical drugs targeting SARS-CoV-2 main protease
A critical player in the virus’s life cycle is the main protease (Mpro), also known as NSP5 or 3CL protease, which plays a crucial role in the cleavage and maturation of SARS-CoV-2 proteins within the host cells.
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NewsAntiviral-resistant variants of SARS-CoV-2 can emerge in immunocompromised people
Individuals with compromised immunity and persistent COVID-19 infections can harbor drug-resistant variants of the SARS-CoV-2 virus, which have the potential to spread to the general population.
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NewsOptimal timing maximises Paxlovid benefits for treating COVID-19
Study suggests using the anti-COVID-19 treatment Paxlovid three to five days after symptoms emerge in patients and expanding global access to the drug may help reduce the severity and transmission of the SARS-CoV-2 virus.
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NewsScientists uncover how coronavirus defends itself against our immune system
A research team identifies “protective switches” in the protein of the SARS-CoV-2 virus.
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NewsOne in five patients experience rebound COVID after taking Paxlovid, new study finds
While Paxlovid remains a ‘life-saving drug,’ researchers found that patients experiencing virologic rebound after treatment may remain contagious.
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NewsMolnupiravir dose of human effect size-equivalent blocks Covid transmission in ferrets
Two oral drugs provide equivalent therapeutic benefit in preventing severe COVID-19 in animal models, but only molnupiravir efficiently blocked SARS-CoV-2 transmission when administered at a human effect size-equivalent dose.
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NewsResearchers use mass spectrometry to explore antimicrobial resistance
Researchers are using single-cell mass spectrometry to determine whether cells with persistent pathogens will also have less intracellular drug levels to potentially explain antimicrobial treatment failure.
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NewsStudy finds evidence of resistance to COVID-19 drugs
Resistance to Paxlovid is already evident among viral SARS-CoV-2 variants currently circulating globally, indicating that this stand-alone drug known as a protease inhibitor could soon become less effective in treating COVID-19 infections, a new study suggests.