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    Gut bacterial enzyme worsens colitis by switching off a protective intestinal signal

    2026-09-16T11:51:00Z

    Microbiome research often focuses on which microbes are present in the gut and what small molecules they produce. But gut bacteria also make enzymes that can act directly on molecules produced by the host. Researchers report that one such bacterial enzyme can weaken a protective intestinal signal and aggravate colitis in a preclinical model.