All Vaccinology articles – Page 16
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Smallpox vaccine induces immunity against monkeypox infection in people living with HIV
Researchers have shown that intradermal vaccination with the JYNNEOS vaccine against smallpox is the best option to protect people living with HIV from contracting the monkeypox virus.
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Nasal spray with antibodies could prevent COVID-19
Researchers have shown that nasal drops with IgA antibodies can protect mice from SARS-CoV-2 infection.
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First-in-human vaccine trial for deadly Nipah virus launched
The University of Oxford has launched a new clinical trial to test a vaccine to protect people against deadly Nipah virus. The first clinical trial participants received doses of the ChAdOx1 NipahB vaccine over the last week.
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Sickle cell raises COVID-19 risk, but vaccination lags
Adults with sickle cell disease around half as likely to have had initial doses as people without sickle cell disease, a study in Michigan shows.
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Potential nasal COVID-19 vaccine candidate offers better and longer protection
Study shows that administering a COVID-19 vaccine as a nasal spray rather than a subcutaneous injection enhances the body’s long-term immune memory, thereby increasing the vaccine’s overall effectiveness.
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Valneva vaccinates first participant in pediatric trial of single-shot Chikungunya vaccine
Valneva SE has announced that the first participant has been vaccinated in the Phase 2 clinical trial evaluating the safety and immunogenicity in children of two different dose levels of Valneva’s single-shot chikungunya vaccine.
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Vaccine boosts innate immunity in people with dormant immune cells
Epigenetic cell states predict whether or not an individual profits from the “wake-up call” to the innate immune system that is provided by the BCG vaccine.
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COVID-19 vaccine strongly effective for children and adolescents during delta and omicron
Children and adolescents who received one of the main COVID-19 vaccines were significantly protected and showed no increased signs of cardiac complications compared to young people who were not vaccinated.
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WHO prequalifies a second malaria vaccine
WHO has added the R21/Matrix-M malaria vaccine to its list of prequalified vaccines.
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Study reveals clues to how Eastern equine encephalitis virus invades brain cells
An atomic-level investigation of how Eastern equine encephalitis virus binds to a key receptor and gets inside of cells also has enabled the discovery of a decoy molecule that protects against the potentially deadly brain infection, in mice.
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Simplified formulation of oral cholera vaccine, licensed by Korean regulatory agency
Euvichol-S, a simplified formulation of oral cholera vaccine, has been licensed by Korean regulatory agency, and is expected to alleviate global cholera vaccine shortages.
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“Honey, I shrunk the cookbook” – new approach to vaccine development
Bioinformaticians have presented a method for identifying epitopes that promise safe immunisation across the broadest possible population group.
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New study explores malaria invasion to help develop life-saving vaccine
An innovative project investigates the progression of malaria infection and the role of the parasite to better aid the development of an effective malaria vaccine and significantly reduce rates of deaths from the disease.
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B cell deficient patients gain protective T cell immunity after SARS-CoV-2 vaccination, infection
Researchers found that vaccinated B cell-deficient individuals had significantly reduced risk of moderate and severe disease in comparison to those who were not vaccinated, despite an absence of anti-spike antibody responses.
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Researchers to develop vaccine candidates against Marburg viruses
The multidisciplinary European consortium MARVAX will receive 7.4 million euros over the next four years for the research and development of vaccines against Marburg viruses.
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Researchers ID opportunities to improve future HIV vaccine candidates
An effective HIV vaccine may need to prompt strong responses from immune cells called CD8+ T cells to protect people from acquiring HIV, according to a new study.
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Researchers pave way for next generation COVID-19 immunization strategies
A vaccine booster delivered directly to mucosal site of infection enhances protection against COVID-19 infection in non-human primates, a new study reveals.
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Risk of death reduces after COVID-19 vaccine but protection wanes after six months
The risk of death from COVID-19 decreases significantly after vaccination but this protection diminishes after six months, providing evidence for continued booster doses, a new study has found.
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Mpox vaccine triggers equally strong immune response in smaller doses
Delivering the two-dose mpox vaccine in smaller than the usual FDA-approved doses produced a detectable immune response. This also occurred regardless of whether people were living with or without HIV.
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Researchers develop a novel dry-powder inhaled vaccine platform
Researchers have developed a single-dose, dry-powder, inhalable vaccine platform using nano-micro composite multilevel structures, which is effective in blocking respiratory viral infection and transmission in animal models.