All adeno-associated virus articles
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NewsEnhanced inner ear tropism of Adeno-Associated Virus (AAV) vectors via peptide display on AAV1 capsid
Researchers improving efficiacy of AAV)-mediated gene therapy for the inner ear screened and inserted short peptide motifs onto the surface of the AAV1 capsid. These engineered vectors achieved markedly higher transduction rates in inner ear hair cells and supporting cells.
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NewsGenetic ‘Trojan horse’ selectively kills cancer cells linked to Kaposi’s sarcoma
A highly targeted gene therapy that could revolutionize treatment for cancers linked to a common herpesvirus harnesses an adeno-associated virus (AAV) to deliver a genetic “Trojan horse” into infected cells.
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News‘One and done’: A single shot at birth may shield children from HIV for years, study finds
A new study shows that delivering a single injection of gene therapy at birth may offer years-long protection against HIV, tapping into a critical window in early life that could reshape the fight against pediatric infections in high-risk regions.
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NewsScientists target viral enzymes to strengthen brain immunity against HSV-1
A new study uncovers how HSV-1 disables the brain’s antiviral defense—and how this defense can be restored. The study offers a promising new therapeutic strategy for treating HSV-1 encephalitis by reactivating the host’s intrinsic immune system.
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NewsBreakthrough gene therapy offers hope for rare, deadly heart disease in young men
Researchers have designed a gene-therapy strategy that could transform the treatment of arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5), a rare and deadly heritable disease that particularly affects young men.
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NewsEvaluating DNA impurities in recombinant adeno-associated virus
A new study indicates that DNA impurities derived from plasmid and host cell DNA are encapsulated into recombinant adeno-associated virus (rAAV) capsids as single-stranded DNA.
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NewsNovel nanosensing technique offers quality control of viral vectors in gene therapy
Researchers report a novel nanosensing technique to measure viral vector characteristics, measuring the ionic current that flows through a nanopore opening when a voltage differential is applied to a solution containing adeno-associated virus.
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NewsNew, modified CRISPR protein can fit inside virus used for gene therapy
Researchers have developed a novel version of a key CRISPR gene-editing protein that shows efficient editing activity and is small enough to be packaged within a non-pathogenic virus that can deliver it to target cells. Hongjian Wang and colleagues at Wuhan University, China, present these findings May 23rd in the ...
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NewsComplement system response to AAV vector gene therapy
Recent clinical trials utilizing high doses of adeno-associated virus (AAV) vectors have highlighted a new challenge to AAV gene transfer – activation of the complement system.
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NewsGene-editing technology eliminates EV-A71 RNA viruses
Scientists have developed a CRISPR-Cas13 therapeutic against EV-A71, the RNA virus that causes hand, foot, and mouth disease.