All Leibniz Institute for Natural Product Research and Infection Biology articles
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Fungus uses surface protein of its spores to weaken human immune system
An international research team discovered a special enzyme on the surface of the spores of Aspergillus fumigatus apparently suppresses the release of pro-inflammatory substances by immune cells, making it easier for the pathogen to spread in the tissue.
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Pandemic stranding ended up helping to solve mystery of synthetic polymers and fungi
A chemistry PhD student who was stranded during the pandemic used the time for research on Candida albicans, leading to a successful collaboration between natural product researchers and infection biologists from Germany and Australia.
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Candida albicans toxin plays a special role in the colonization of the digestive tract
Comparative studies on mice with a complete microbiome and a microbiome reduced by antibiotics now show that the previous assumption that the yeast form of Candida albicans is better suited for colonization needs to be revised.
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Insights into release of fungal toxin promise progress in treating infections
The toxin Candidalysin of the yeast Candida albicans is incorporated into an unusual protein structure during an infection, and researchers have now succeeded in deciphering the function of this unusual arrangement.
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Aspergillus fumigatus adapts to life in humans - and shapes their lung microbiome
Aspergillus fumigatus strains that infect humans have a significantly altered metabolism compared to other strains in the environment. At the same time, infection with the fungus leads to an apparent change in the human lung microbiome. Source: CDC Photomicrograph revealing ultrastructural morphology exhibited by the fungal organism Aspergillus ...
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Just one single molecule can disrupt symbiosis
Researchers have found that the bacterial species Mycetohabitans rhizoxinica lives happily in the hyphae of the fungus Rhizopus microsporus only when the bacteria produce a certain protein.
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Streptomycetes reveal their arsenal of signalling compounds
Streptomyces bacteria produce a group of signalling molecules that trigger a variety of processes, a new study shows.
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Hydrogen-fuelled bacteria can produce wide range of chemicals
Researchers probing microbial electrosynthesis have confirmed experimentally for the first time that the bacteria use electrons from hydrogen and can produce more chemical substances than previously known.
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Intestinal bacteria influence the growth of fungi
The bacteria present in the intestine provide information about the quantities of fungi of the potentially disease-causing Candida genus - among them, surprisingly, are lactic acid bacteria that are known for their protective effect against fungal infections.
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Fungal spores bind to lung cell protein to escape human defences
The pathogenic fungus Aspergillus fumigatus escapes elimination from surface cells of the human lung by binding to a human protein.
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Deadly Keanu-inspired bacterial compound delivers excellent anti-fungal protection to plants
Researchers have proved that an antimicrobial natural product produced by Pseudomonas - and named after Keanu Reeves - is effective against both plant fungal diseases and human-pathogenic fungi.