All Mass General Brigham articles
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NewsTrial finds vitamin D supplements don’t reduce Covid severity but could reduce long COVID risk
In a large, randomized trial, researchers have found that high-dose vitamin D3 did not reduce COVID-19 infection severity, but may impact long COVID outcomes.
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NewsVirus-based therapy boosts anti-cancer immune responses to brain cancer
A study has shown that a single injection of an oncolytic virus—a genetically modified virus that selectively infects and destroys cancer cells—can recruit immune cells to penetrate and persist deep within brain tumors.
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NewsHow genes influence the microbes in our mouths
A new study has found human genetic factors that influence the oral microbiome and may increase risk of cavities and tooth loss in some people. Analysis of the now largest collection of oral microbiome profiles reveals interactions between human and bacterial DNA.
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NewsWhat causes some people’s gut microbes to produce high alcohol levels?
A study of people with a rare condition known as auto-brewery syndrome has found a link between gut microbes and symptoms of intoxication, pointing to new treatment strategies.
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NewsCholera vaccine completes phase 1 trial
A clinical trial shows promising results for PanChol, a single-dose oral vaccine aimed at the up to 4 million annual cholera cases worldwide.
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NewsEngineered virus boosts immune response against glioblastoma in preclinical models
Researchers have modified a herpes simplex virus (HSV-1) that stimulates the immune system to attack glioblastoma cells. A single dose of the modified virus increased T-cell, natural killer cell, and myeloid cell responses in the tumor microenvironment and increased the overall survival in preclinical models.
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NewsResearchers identify why some people with HIV achieve remission after antibody treatment
Researchers have discovered why some people living with HIV who are given broadly neutralizing anti-HIV antibodies (bNAbs) can safely stop taking standard, lifelong HIV medications and maintain control of the virus for years, while others given the same treatment do not achieve this remission.
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NewsCOVID-19 during pregnancy linked to higher risk of neurodevelopmental disorders in children
Children born to mothers who had COVID-19 while pregnant face an elevated risk of developmental disorders by the time they turn 3 years old, including speech delays, autism, motor disorders, and other developmental delays, according to new research.
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NewsStudy finds HEPA purifiers alone may not be enough to reduce viral exposure in schools
In a secondary analysis of a study of 200 classrooms, researchers found respiratory viral exposures were still high in those with HEPA purifiers, suggesting additional interventions are needed.
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NewsBlood test identifies HPV-associated head and neck cancers up to 10 years before symptoms
Researchers show that a novel liquid biopsy tool called HPV-DeepSeek can identify HPV-associated head and neck cancer up to 10 years before symptoms appear.
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NewsClinical trial finds safe, effective treatment for children with severe post-Covid syndrome
Researchers have discovered that a drug designed to treat Celiac disease supported a more rapid return to normal activities for patients following COVID. A small, randomized clinical trialfound the oral drug larazotide was both safe and effective in treating children with MIS-C.
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NewsNew blood test shows superior sensitivity in detecting HPV-associated head and neck cancers
A new liquid biopsy blood test could help detect cases of human papillomavirus (HPV)-associated head and neck cancers with significantly higher accuracy than currently used methods, including before patients develop symptoms.
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NewsEliminating HIV funding program would lead to >600k deaths in South Africa alone: warning
A new analysis finds that eliminating PEPFAR would lead to 601,000 HIV-related deaths, 565,000 new HIV infections, and would increase population-level healthcare expenditure by $1.7 billion over the next decade in South Africa alone.
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NewsLong-term yogurt consumption tied to decreased incidence of certain types of colorectal cancer
A new study finds that yogurt consumption over time may protect against colorectal cancer through changes in the gut microbiome. Long-term consumption of two or more servings per week of yogurt was tied to lower rates of proximal colorectal cancer positive for Bifidobacterium.
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NewsUltrasensitive test detects, serially monitors intact virus levels in patients with COVID-19
A highly sensitive approach, adapted from cancer vesicles detection, was discovered to be able to detect SARS-CoV-2 viral particles in fluid samples of patients with acute COVID-19 infections.
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NewsStudy reveals best timing for getting the RSV vaccine during pregnancy to protect newborns
Researchers found that getting vaccinated on the early side of the recommended window was best for transferring maternal antibodies to the fetus.
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NewsExperts develop laboratory toolkit for patients with viral hemorrhagic fevers such as Marburg virus disease
New resource provides guidance for healthcare facilities to perform basic laboratory testing in a safe and effective manner for patients at risk for Viral Hemorrhagic Fevers.
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NewsObesity may increase susceptibility to contracting COVID-19
Electronic health record data revealed that individuals with obesity were 34% more likely to become COVID positive after reported exposure than individuals without obesity.
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NewsCOVID-19 infection causes teen’s vocal cord paralysis in first-of-its-kind case
Physician-researchers have reported the first pediatric case of bilateral vocal cord paralysis after COVID-19 infection.
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NewsB cell deficient patients gain protective T cell immunity after SARS-CoV-2 vaccination, infection
Researchers found that vaccinated B cell-deficient individuals had significantly reduced risk of moderate and severe disease in comparison to those who were not vaccinated, despite an absence of anti-spike antibody responses.