All Microbiological Methods articles – Page 4
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NewsNew single‑cell technique reveals how tuberculosis‑like bacteria alter human cells
Researchers have developed a new technique to measure the content of individual human cells infected with bacteria that model tuberculosis – and it is already revealing biological changes that conventional analysis would miss.
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NewsPenicillin–streptomycin influences macrophage mechanical properties and microenvironment mechano-sensation
A foundational finding in mechanobiology reveals that penicillin-streptomycin (pen-strep), the antibiotic mixture universally added to mammalian cell culture media, is not a biologically inert antimicrobial agent.
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NewsTeam simulates a living cell that grows and divides
By simulating the life cycle of a minimal bacterial cell — from DNA replication to protein translation to metabolism and cell division — scientists have opened a new frontier of computer vision into the essential processes of life.
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NewsStudy writes the catalog of plasma membrane repair proteins
A new study identifies 80 proteins involved in plasma membrane repair in budding yeast, laying the foundation for membrane repair studies and future therapeutic applications.
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NewsArtificial feeding platform transforms study of ticks and their diseases
The world’s first lab-based tick feeding system for bush ticks has transformed the study of ticks and how they transmit disease. The novel, host-free technology reduces the need for animal experiments in tick studies, facilitating more ethical, reproducible research.
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NewsThermo Fisher Scientific launches new color-based culture media to help detect Candida infections faster
Thermo Fisher Scientific today announced the launch of Thermo Scientific™ Brilliance™ Candida 2 Agar and Spectra™ Candida Agar, new color-based (chromogenic) culture media to help laboratories quickly detect and differentiate clinically important Candida species.
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NewsNew tool reveals the secrets of HIV-infected cells
Scientists have developed a novel tool—named HIV-seq—for profiling the features of rare HIV-infected cells from people with HIV. Using the new tool, they’ve found key differences in people’s HIV-infected cells before versus after starting antiretroviral therapy.
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NewsChemically ‘stapled’ peptides used to target difficult-to-treat cancers
Researchers have developed a new technology that uses bacteria to build, chemically stabilise, and test millions of potential drug molecules inside living cells. The bacteria produce vast libraries of peptide molecules, and chemically stabilise them into defined shapes while they are being tested inside the cell.
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NewsResearchers find a gentler way to treat aggressive gum disease
Researchers have discovered that the primary bacterium driving gum disease carries an internal “genetic brake” that controls its own aggression. By locking this brake in place, future treatments could silence the pathogen while leaving beneficial bacteria untouched.
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NewsA common CRISPR platform enables comparative studies of multicellularity in social amoebae
Researchers have established a CRISPR genome editing technique that enables comparative analysis of the evolution of multicellularity across different species of social amoebas (cellular slime molds). Until now, genetic studies had been largely restricted to a single model species.
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NewsNew single-cell transcriptomic clock reveals intrinsic and systemic T cell aging in COVID-19 and HIV
Scientists developed a new single-cell transcriptomic clock called T immune cell transcriptomic clock (Tictock) to measure aging in specific immune cells. They found that in patients with acute Covid-19, the infection increased the biological age of naïve CD8 T cells.
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NewsA yeast enzyme helps human cells overcome mitochondrial defects
An international team has experimentally uncoupled nucleotide synthesis from mitochondrial activity using ScURA, a yeast-derived genetic tool now available to the research community that will enable new explorations of cellular metabolism.
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NewsSilent enemies, smart weapons - switching off phage contamination using nanoparticles
Bacteriophages represent a serious threat to laboratories and industries that rely on bacterial cultures for production. Researchers have demonstrated an innovative solution that enables targeting the surface of bacteriophage through electrostatic interactions.
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NewsStiff gels slow germs: New study maps hydrogel properties that control bacterial growth
Scientists has found that firmer, lower water content hydrogels limit bacterial growth, with implications for designing antibacterial coatings, infection models, and advanced medical materials.
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NewsResearchers rebuild microscopic circadian clock that can control genes
Researchers have solved how the circadian clocks within microscopic bacteria are able to precisely control when different genes are turned on and off during the 24-hour cycle.
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NewsScientists create ‘smart underwear’ to measure human flatulence
Scientists have created Smart Underwear, the first wearable device designed to measure human flatulence. The device helps scientists revisit long-standing assumptions about how often people actually fart. It also opens a new window into measuring gut microbial metabolism in everyday life.
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NewsNew algorithm enhances microbiome biomarker discovery by integrating biological relationships
Researchers have developed a novel algorithm, Microbiome Elastic Feature Extraction (MEFE), that significantly improves the identification of microbiome biomarkers by incorporating phylogenetic, taxonomic, and functional relationships among microbes.
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News Engineered moths could replace mice in research into “one of the biggest threats to human health”
Scientists have created the world’s first genetically engineered wax moths – a development which could both accelerate the fight against antimicrobial resistance (AMR) and significantly reduce the need for mice and rats in infection research.
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NewsNext generation genetics technology developed to counter the rise of antibiotic resistance
The new Pro-Active Genetics (Pro-AG) tool called pPro-MobV is a second-generation technology that uses an approach similar to gene drives to disable drug resistance in populations of bacteria.
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NewsA standout solvent for today’s biorefineries
Researchers tested multiple distillable amine-based solvents to see how they performed in pretreatment processes for biomass. They found butylamine was a superior solvent.