A new paper in Biology Methods and Protocols, published by Oxford University Press, suggests researchers studying SARS-CoV-2 may have developed new methods to administer vaccines orally, which would be both easier to administer and more effective at combatting illnesses.


The best way to neutralize viruses is before they can enter inside human cells but are only on the external surface of epithelial cells that line and produce mucus in the lungs, nose, and mouth. A specific class of antibodies known as Immunoglobulin A operates in mucus and can disable viruses.

However, production of specific immunoglobulins/antibodies for a given virus has to be first induced by a vaccination. Vaccination that effectively produces Immunoglobulin A antibodies rapidly would better prevent disease.

Secretion in mucosa

Since the coronavirus, like influenza, infects bronchial cells, researchers believe it is important to induce the secretion of virus antigen-specific Immunoglobulin A in the mucosa rather than in the blood.

Recently, scientists have developed vaccines administered via alternative routes, such as nasal or oral. Such vaccines are more effective in inducing Immunoglobulins A than those administered by conventional subcutaneous vaccinations.

Although doctors have used nasal vaccines in clinics, they have found that these vaccines tend to produce side effects on the central nervous system or lungs, such as headaches and fever.

Under the tongue

This study examined a new vaccination against SARS-CoV-2 designed to induce production of Immunoglobulin A orally (under the tongue) in monkeys. The method worked and animals used for the test produced the necessary antibodies against the disease without discernable side effects.

This suggests that, with further research, clinics may soon be able to offer oral vaccines against the coronavirus, which would be more popular and more successful against the disease.

The paper, “SARS-CoV-2 Sublingual Vaccine with RBD Antigen and Poly(I:C) Adjuvant: Preclinical Study in Cynomolgus Macaques,” is available at: doi.org/10.1093/biomethods/bpad017.