All Vaccinology articles
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Study links influenza A viral infection to microbiome, brain gene expression changes
Infection with influenza A is found to be associated with disruptions in newborn piglets’ nasal and gut microbiomes and with potentially detrimental changes in gene activity in the hippocampus, a brain structure that plays a central role in learning and memory.
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Supercharged HIV vaccine could offer strong protection with just one dose
Researchers have shown that they can generate a strong immune response to HIV with just one vaccine dose, by adding two powerful adjuvants — materials that help stimulate the immune system.
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Vaccine disguised as a virus tricks the body into stronger immunity
A simple addition to mRNA vaccines can significantly enhance their effectiveness. Scientists have shown that mice develop a stronger and longer-lasting immune response when the mRNA vaccine is disguised as virus-like particles.
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New vaccine works against multiple fungal infections
A vaccine developed by University of Georgia researchers successfully protects against and treats vaginal yeast infections in mice, according to a study.
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Launch of first-in-human clinical trial of next-generation rotavirus vaccine delivered via dissolvable microarray technology
Scientists have announced the first clinical trial of a novel rotavirus vaccine, CC24, delivered via dissolvable microarray technology, is now enrolling participants.
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Vaccinated patients hospitalized with COVID-linked acute kidney injury less likely to need dialysis after discharge
Vaccinated patients hospitalized with COVID-19 who developed acute kidney injury had better outcomes than unvaccinated patients with the same condition, new research suggests. The study found vaccinated patients were less likely to stay on dialysis after discharge, and more likely to survive, than unvaccinated patients.
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An oral cholera vaccination campaign aims to reach more than 2.6 million people in Sudan’s Khartoum State
A 10-day reactive oral cholera vaccination campaign, launched on 10 June in 5 localities in Sudan’s Khartoum State, aims to protect more than 2.6 million people aged 1 year and above from cholera infection, interrupt transmission and help contain the cholera outbreak.
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People with inflammatory RMD tolerate zoster vaccine well, study finds
New work presented at the 2025 annual EULAR congress in Barcelona focuses on the recombinant zoster vaccine (RZV), which contains recombinant glycoprotein E – the major target of CD4+T-cells. The abstract describes the tolerability and safety of RZV in patients with inflammatory rheumatic and musculoskeletal diseases (iRMD).
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SHEA affirms trust in ACIP and supports science-based vaccine policy
Public health experts have commented on the removal by the US Department of Health and Human Services (HHS) of all 17 members of the Advisory Committee on Immunization Practices (ACIP), which advises the Centers for Disease Control and Prevention (CDC) on the use of vaccines in the US.
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Researchers pioneer nanoparticle approach to fight poultry disease
Researchers have demonstrated that a novel protein-based nanoparticle can make mRNA vaccines more effective to tackle a troublesome pathogen in chickens.
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Global Virus Network issues scientific guidance on new COVID-19 variant NB.1.8.1 and vaccine protection
The Global Virus Network (GVN) is closely monitoring the emergence of a newly identified SARS-CoV-2 variant, NB.1.8.1, a sublineage of the Omicron family first identified in January 2025 and which has rapidly spread across Asia and into other regions.
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Global study: COVID-19 and adenoviral vaccines tied to GBS risk, not mRNA vaccines
A large-scale study in a population covering more than 230 million people sheds light on the relationship between Guillain-Barré syndrome after COVID-19 vaccines or SARS-CoV-2 infection.
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New mRNA vaccine is more effective and less costly to develop, Pitt study finds
A new type of mRNA vaccine is more scalable and adaptable to continuously evolving viruses such as SARS-CoV-2 and H5N1, according to a study.
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New data shows MMR vaccination rate decline across US
A new county-level dataset reveals a national decline in the measles-mumps-rubella (MMR) vaccination rate among U.S. children since the start of the COVID-19 pandemic.
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Earlier measles vaccine could help curb global outbreak
The global measles outbreak must trigger an urgent debate into whether a vaccine should be recommended earlier to better protect against the highly contagious disease during infancy, a new review states.
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Careers
How structural imaging is revolutionising vaccines
Dr. Peijun Zhang, Director of the Electron Bio-Imaging Centre (eBIC) at the UK’s national synchrotron facility Diamond Light Source, reveals how Cryo-ET is powering some of the most important advances in vaccine research.
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Engineered bacteria can deliver antiviral therapies and vaccines
New research demonstrates how specially engineered bacteria taken orally can operate as a delivery system for antiviral therapies and vaccines.
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Particles carrying multiple vaccine doses could reduce the need for follow-up shots
Researchers are working to develop microparticles that can release their payload weeks or months after being injected. This could lead to vaccines that can be given just once, with several doses that would be released at different time points.
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Two HIV vaccine trials show proof of concept for pathway to broadly neutralizing antibodies
A new study combining data from two separate phase 1 clinical trials shows that a targeted vaccine strategy can successfully activate early immune responses relevant to HIV, and, in one trial, further advance them.
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Proof of concept for HIV vaccination that deploys germline-targeting
For a preventative HIV-vaccine to work it should induce broadly neutralising antibodies against all the diverse strains of the virus. The first in-human assessment of germline-targeting strategy with a trimer displays positive results.