All University of Alabama at Birmingham articles
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NewsOne dose of antibiotic treats early syphilis as well as three doses
Researchers have found that a single injection of the antibiotic benzathine penicillin G (BPG) successfully treated early syphilis just as well as the three-injection regimen used by many clinicians. These findings from a late-stage clinical trial suggest the second and third doses of conventional BPG therapy do not provide a health benefit.
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NewsNovel immunologic surveillance study provides new insights into post-pandemic return of respiratory viruses
Non-pharmaceutical interventions such as masking and distancing targeted towards SARS-CoV-2 during the pandemic also decreased circulation rates of and population immunity to common respiratory pathogens in children, a new study shows.
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NewsWhy killer cells can lapse into ‘exhausted’ CD8+ T cells that no longer can stem disease
In a detailed study of exhausted T cell subsets researchers show that a transcriptional repressor called Gfi1 is a key regulator of the subset formation of exhausted CD8+ T cells and may offer a key to reducing exhaustion.
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NewsAs prevention strategy for sexually transmitted infections rolls out, experts highlight both promise and knowledge gaps
Real-world evidence demonstrates that the postexposure strategy of doxy PEP is reducing the rate of syphilis and chlamydia, but has had little to no effect on gonorrhea and needs close monitoring for signals of antibiotic resistance.
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NewsResearch yields new model for replication of BKPyV virus, a major cause of kidney transplant failure
There are no effective antivirals against BK polyomavirus in transplanted kidneys. A better understanding of its replication will offer new ways to protect those kidneys.
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NewsNew study links historical redlining to delays in HIV treatment
A new study finds that historical race-based lending practices are still impacting health in the US today, linking these discriminatory policies to delays in effective HIV treatment within affected neighborhoods.
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NewsFirst-of-its-kind national trial exploring potential of antibiotics for lowering c-section rates in women with obesity
A multicenter national clinical trial will study whether antibiotics given at the beginning of labor induction result in a decrease in C-sections. The trial is thought to be the first large-scale study of its kind in the United States.
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NewsStructural biology analysis of a Pseudomonas bacterial virus reveals a genome ejection motor
Bacterial viruses, known as phages, are the most abundant biological entities on the planet and are increasingly used as biomedicines to eradicate antibiotic-resistant pathogenic bacteria.
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NewsNIH grant establishes UAB’s Global Research Resource for Human Tuberculosis
A $5.8m grant led by Adrie Steyn, Ph.D., of the University of Alabama at Birmingham and the Africa Health Research Institute, or AHRI, in Durban, South Africa, will provide user-requested infected human lung tissue and analytical services to tuberculosis researchers worldwide.
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NewsGut microbes from aged mice induce inflammation in young mice
New findings suggest that changes to the gut microbiome play a role in the systemwide inflammation that often occurs with aging, and also revealed that antibiotics caused longer-lasting disruptions in gut microbiomes of aged mice than in young mice.
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NewsResearchers take step toward development of universal COVID-19 antibodies
Scientists have developed a promising new human monoclonal antibody that appears a step closer to a universal antibody cocktail that works against all strains of SARS-CoV-2.
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NewsKey role found for gut epithelial cells in the defense against deadly diarrheal infections
A newly identified subset of intestinal epithelial cells act as both the major target and a key responder in a mouse model of gut infection by the bacteria Citrobacter rodentium.