All USA & Canada articles – Page 104
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Engineered bacteria guide CAR-T cells to poorly infiltrated solid tumors
A new probiotic-guided chimeric antigen receptor (CAR)-T platform uses engineered bacteria to infiltrate and produce synthetic antigen targets, enabling CAR-T cells to find, identify, and destroy tumor cells in situ, according to a new study.
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Using different flours for sourdough fosters different bacteria – and flavours
A new study of the microbial ecosystem in sourdough finds that using different types of flour fosters distinct bacterial communities, and that these differences contribute to the variation of sourdough aromas and flavours.
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AI tool can help forecast viral outbreaks
A new AI tool called EVEscape uses evolutionary and biological information to predict how a virus could change to escape the immune syste, and successfully predicted the most concerning new variants that occurred during the COVID-19 pandemic.
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A mother mouse needs a diverse gut microbiome to form a healthy placenta
Pregnant mice with no gut microbiome or diminished microbiomes aren’t able to form the healthy placentas necessary for proper fetal development, but supplementing these mice with short-chain fatty acids promotes healthy placental development.
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World-first comprehensive pan-genome analysis of lactic acid bacteria
A team of international researchers has published the first comprehensive comparative pan-genome analysis of lactic acid bacteria (LAB), a family of microorganisms essential to natural ecosystems and the food industry.
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TB vaccine discovery paves path to end no. 1 killer of people living with HIV
Scientists have discovered a tuberculosis (TB) vaccination strategy that could prevent the leading cause of death among people worldwide living with HIV.
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Remains of 1918 flu pandemic victims contradict belief that healthy young adults were particularly vulnerable
New analysis of the remains of victims of the 1918 influenza pandemic, which killed an estimated 50 million people worldwide, contradicts the widespread belief the flu disproportionately impacted healthy young adults.
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Prior exposure to common virus shields against birth defects and miscarriage
A new study uncovers how pre-existing immunity to Cytomegalovirus (CMV) may significantly reduce the risk of birth defects and miscarriage during pregnancy, offering hope for a future vaccine.
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Wastewater surveillance research provides 12-day lead time for RSV season
Researchers using wastewater surveillance over conventional indicators have predicted the start of the annual respiratory syncytial virus (RSV) season 12 days early, providing more lead time for hospital preparedness.
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Single vaccine shot could thwart eight hospital superbugs
A single dose of an experimental vaccine, administered in mouse models, can provide rapid protection against eight different bacteria and fungi species.
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Researchers receive international funding to study spiderwebs as biosensors
The dew-covered spiderweb you see in your yard might soon become a platform to detect airborne viruses, according to Jiangtao Cheng, who hopes to build bio-inspired technology that could serve as an early warning system for pathogens.
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Scientists discover alternative base modification for mRNA therapeutics
Researchers have incorporated a newly discovered base, called base Z, into mRNA to create Z-mRNA that has improved translational capacity, decreased cytotoxicity and drastically reduced immunogenicity compared to unmodified mRNA.
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Emerging diseases threatening trees around the world are accelerating
A study analyzing more than 900 new disease reports on 284 tree species in 88 countries found that the number of new disease emergences globally is doubling every ~11 years, with pines accumulating the most new diseases.
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New recommendation on meningitis vaccines for infants in sub-Saharan Africa
An IDCRC study assessing the meningococcal pentavalent (five in one) vaccine for infants in Africa shows vaccine provides protection against meningococcal meningitis.
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Acid-tolerant yeast engineered to produce valuable organic acid from plants
Researchers have engineered an acid-tolerant yeast to economically produce succinic acid, a key chemical in food, agricultural and pharmaceutical products, savings on money and emissions.
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Researcher awarded $1.9m to develop model to test phages in the gut
Bryan Hsu, an assistant professor of biological sciences at Virginia Tech, has received a five-year $1.9 million award to develop a model to test the role of lytic bacteriophages, or phages as they are commonly called, in the mammalian gut.
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Oral lipid nanoparticle drug can prevent development of colitis-associated cancer
An oral lipid nanoparticle drug prevents tumor development in mice, suggesting this is a promising drug formulation for preventing colitis-associated cancer, according to a study led by researchers in the Institute for Biomedical Sciences at Georgia State University. The findings published in the journal Pharmaceutics report the ...
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Gut bacteria from wild wolves may be key to improving domestic dogs’ health
Gut microbes found in wild wolves may be the key to alleviating a debilitating gastrointestinal condition common to domestic dogs, according to a new study.
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Metal-loving microbes could replace chemical processing of rare earths
Scientists have characterized the genome of a metal-loving bacteria with an affinity for rare earth elements, paving the way towards replacing the harsh chemical processing of these elements with a benign practice called biosorption.
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Versatile vaccine candidate fights measles, mumps and Covid
Altered measles and mumps viruses could be used as a platform to create a trivalent COVID-19 vaccine that triggers immunity to multiple variant strains of the SARS-CoV-2 virus, new research in animals suggests. The study builds upon previous studies that involved inserting a highly stable segment of ...