All viral reservoirs articles
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NewsThe Wistar Institute wins $15M+ NIH investment to advance HIV cure research strategies
The Wistar Institute has announced the National Institutes of Health (NIH) has awarded two major grants totaling more than $15M to Luis J. Montaner, D.V.M., D.Phil., director of Wistar’s HIV Cure and Viral Diseases Center.
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NewsStudy finds HIV-1 proviruses may drive chronic systemic inflammation
People living with HIV are at higher risk of developing inflammatory diseases of many tissues, even when receiving antiviral treatments. A new study suggests that persistent hidden HIV contributes to this inflammation.
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NewsHow bats tolerate viruses: study sheds light on one of nature’s biggest immune mysteries
Researchers have found that the world’s largest family of bats has two distinct copies of the genes that produce antibodies, the specialized proteins that help the immune system recognize and fight infections. Every other known mammal has only one such set.
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NewsNext-generation ‘molecular scissors’ may offer hope for chronic hepatitis B sufferers
Researchers have developed engineered precision ’molecular scissors’ that can permanently disable the genetic blueprint of the hepatitis B virus (HBV). The approach directly targets covalently closed circular DNA (cccDNA), the stubborn viral reservoir.
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NewsHIV discovery could open door to long-sought cure
Scientists have uncovered a key reason why HIV remains so difficult to cure: Their research shows that small changes in the virus affect how quickly or slowly it replicates, and how easily or stubbornly it can reawaken from hiding.
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NewsScientists develop new natural killer cell strategy to target HIV
Scientists have successfully identified a new approach using natural killer (NK) cells to target and kill the HIV-positive cells that allow the virus to persist. They genetically modified NK cells to express CD64, a protein not normally expressed by NK cells.
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NewsCovid persistence in lungs linked to failure of innate immunity
A new study shows that SARS-CoV-2 is found in the lungs of certain individuals for up to 18 months after infection, and that its persistence appears to be linked to a failure of innate immunity (the first line of defense against pathogens).