Adults hospitalised with the SARS-CoV-2 Omicron variant have a higher death rate than those hospitalised with seasonal influenza, even though Omicron is considered less virulent with lower case fatality rates than the delta and alpha strains, new research being presented at this year’s European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) in Copenhagen, Denmark (15-18 April) suggests.


The study by Dr Alaa Atamna and colleagues from the Rabin Medical Center at Belinison Hospital in Israel found that adults (18 years or older) hospitalised with influenza were 55% less likely to die within 30 days than those hospitalised with Omicron during the 2021-2022 influenza season.

Influenza and COVID-19 are both respiratory diseases with similar modes of transmission. In December 2021, influenza re-emerged in Israel after it went undetected since March 2020. At the same time, the Omicron had substituted Delta as the predominant variant. But data directly comparing Omicron with seasonal influenza are scarce.

Clinical outcomes

To find out more, researchers compared the clinical outcomes of patients hospitalised with COVID-19 (Omicron variant) and those hospitalised with influenza at a large academic hospital in Israel.

Consecutive patients hospitalised with laboratory confirmed COVID-19 (167 patients; average age 71 years, 58% male) and influenza infection (221 patients; average age 65 years, 41% male) during December 2021 and January 2022 were included in the study.

 Overall, 63 patients died within 30 days—19 (9%) admitted with influenza and 44 (26%) hospitalised with Omicron.

Patients with Omicron tended to have higher overall comorbidity scores, needed more assistance performing activities of daily living (e.g., washing and dressing), and were more likely to have high blood pressure and diabetes, whereas asthma was more common in those hospitalised with influenza (see table 1 in notes to editors).

Respiratory complications and need for oxygen support and mechanical ventilation were also more common in Omicron cases than in seasonal influenza.

Underlying reasons

“A possible reason for the higher Omicron death rate is that patients admitted with Omicron were older with additional major underlying illnesses such as diabetes and chronic kidney disease,” says Dr Atamna. “The difference might also be due to an exaggerated immune response in COVID-19, and that vaccination against COVID-19 was far lower among patients with Omicron.”

He continues, “The double whammy of overlapping influenza and COVID-19 epidemics will increase the complexity of disease and the burden on health systems. There is one basic step people can take that may alter the trajectory of either epidemic - get the vaccines for flu and COVID-19, especially if you are older and have underlying illnesses.”

The authors point out that the study was observational so can’t prove causation, and it was conducted in one hospital in Israel so the results may not apply to other countries and populations. And they cannot rule out the possibility that other unmeasured factors such as influenza and COVID19 vaccination status may have influenced the results.

They also note that the excess mortality observed for Omicron could be the result of an influenza season that was less severe than usual. Finally, the study included only hospitalised patients, so could not estimate the proportion of hospitalised patients in the total number of infected patients.