All Infectious Disease articles
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Cohort data from Denmark show real-world evidence of stable protection against HPV-related cervical cancer
Denmark has been offering free vaccination against human papillomavirus (HPV) to girls since 2008. New data show vaccination has effectively reduced infections with cancerogenic HPV 16/18 types covered by the vaccine, indicating population immunity.
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Researchers develop mRNA-based vaccine against a deadly plague-causing bacterium
Researchers have used the platform developed for COVID-19 vaccines to create the world’s first mRNA-based vaccine against the deadly, antibiotic-resistant bacterium behind pneumonic plague.
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Substances isolated from marine sponges show potential for treating malária
In pre-clinical tests, compounds called batzelladins were found to be effective even against strains of Plasmodium that are resistant to conventional antimalarial drugs.
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Chameleon plant polysccharide targets acute pneumonia with H1N1 and MRSA coinfection
A new study discusses how an anti-complement homogeneous polysaccharide from Houttuynia cordata ameliorates acute pneumonia with H1N1 and MRSA coinfection through rectifying Treg/Th17 imbalance in the gut–lung axis and NLRP3 inflammasome activation.
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New strategy developed to engineer high-affinity receptor-containing antibodies against malaria
Researchers have introduced an innovative approach to developing high-affinity receptor-containing antibodies in vitro, offering a promising strategy to combat malaria.
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Global trends and cross-country inequalities of acute hepatitis E in the elderly, 1990–2021
Acute hepatitis E (AHE) in the elderly can lead to severe complications including liver failure and mortality. A new study aimed to assess the trends and health inequalities of AHE among the elderly over the past three decades, and predict its changes by 2030.
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Thirty years of research shows increased resistance in fungi
Fungi are increasingly resistant to antifungals, and the variation in resistance has significantly increased, reveals an analysis of more than 12,000 lung samples collected over thirty years in Dutch hospitals.
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Structure of tick-borne virus revealed at atomic resolution for the first time
One emerging tick-borne virus in North America is the Powassan virus (POWV), which can cause encephalitis, seizures, paralysis and coma. Rates of POWV infections have increased in recent years and currently, there are no treatments available.
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Prairie dogs carry genes linked to surviving plague
A study of the genetic basis of plague immunity in prairie dogs has broad implications for conservation. By comparing whole-genome sequences, the authors identified genetic variants associated with survivorship.
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Large-scale DNA study maps 37,000 years of disease history
A new study maps infectious diseases across millennia and offers new insight into how human-animal interactions permanently transformed our health landscape.
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Summer travel ‘will increase the spread of measles,’ expert says
The number of measles cases in the U.S. has reached its highest point in 33 years, and outbreaks are expected to continue, especially amid national and international travel.
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Scientists investigate gut microbiota in elderly patients with acute hepatitis E infection
A new study of the impact of hepatitis E virus infection on the gut microbiota identifies a bacterial species as a potential biomarker for disease outcomes.
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Vanderbilt and Parse Biosciences collaborate on new measles treatment
Vanderbilt University Medical Center and Parse Biosciences, an innovator in single-cell sequencing, are collaborating on a new treatment to help unvaccinated measles victims, as the U.S. measles outbreak has now reached its highest case count in 30 years.
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New study suggests Florida has the potential for local Chagas disease transmission
Researchers in Florida have discovered local kissing bugs are harboring the parasite that can lead to Chagas disease, demonstrating that this rare, chronic disease has a secure foothold in the U.S. and warrants more preventative measures.
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Clinical trials reveal promising alternatives to high-toxicity tuberculosis drug
Research shows two novel antibiotics could spare patients from severe side effects. The drugs sutezolid and delpazolid have demonstrated strong antimicrobial activity and a notably better safety profile compared to linezolid.
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Protecting the most vulnerable: ECDC recommendations to address ongoing local transmission of diphtheria
A new ECDC Rapid Risk Assessment highlights how ongoing circulation of diphtheria caused by Corynebacterium diphtheriae may affect some populations who are more vulnerable to infection and issues recommendations to protect those most at risk.
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Tiny antibody has big impact on deadly viruses
Researchers have discovered a strategy to neutralise two lethal viruses for which there is currently no approved vaccine or cure. The team identified the first ever nanobody to work against Nipah and Hendra, henipaviruses which have jumped from animals to people.
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Researchers find compound that inhibits cutaneous HPVs
Researchers have identified a promising new compound that inhibits cutaneous HPV. In lab studies, the compound inhibited viral replication genes in cutaneous HPVs without damaging host cells.
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Low dose of hydroxychloroquine is associated with reduced COVID-19 mortality: study
A new study provides observational evidence that low-dose hydroxychloroquine is associated with reduced COVID-19 mortality in hospitalized patients, particularly those with severe illness, when administered within the first week of symptoms.
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New breakthrough uncovers how to kill ‘zombie’ TB cells resistant to antibiotics
Researchers exposed a library of over 500,000 genetically modified tuberculosis bacteria to two commonly used antibiotics. By analysing the survivors, they pinpointed genes whose disruption significantly reduced the number of surviving persisters.