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NewsLab tackles antibiotic resistance across multiple fronts in new trio of studies
To defeat multidrug-resistant superbugs, bacterial defenses must be confronted wherever they may emerge, from basic genetic mutations in a laboratory, to complex real-world transmission in hospital rooms. A new trio of studies demonstrates how an integrated approach might yet expose and overcome these diverse survival mechanisms.
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NewsFecal microbial signatures show promise for colorectal and pancreatic cancer assessment
Gastrointestinal and pancreatobiliary cancers can be difficult to detect early, creating a need for practical, noninvasive approaches for early detection and risk assessment. The gut microbiome has emerged as a potential source of cancer biomarkers, offering practical opportunities for noninvasive testing, as microbial changes can be assessed in fecal samples. ...
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NewsKey regulator helps seafood-associated bacterium balance iron and oxidative stress
Bacteria need iron, but bioavailable iron is often scarce, and too much can fuel chemical reactions that damage cells. Many Gram-negative bacteria balance iron through ferric uptake regulator (Fur), a metal-responsive protein that controls iron-related genes. Fur’s role in V. parahaemolyticus, however, had not been clearly defined.
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NewsCan AI find drugs to fight infection?
Researchers have used artificial intelligence (AI) to identify approved drugs that may be effective against Streptococcus pneumoniae. Using a dataset of molecules shown to be active against S. pneumoniae and a larger dataset of molecules inactive against another drug-resistant bacterium, the scientists trained three different learning algorithms.
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NewsBreakthrough optimization of chlamydospore fermentation for Cladophialophora guangxiense HX2
The dark septate endophyte Cladophialophora guangxiense HX2 exhibits excellent control efficacy against tomato bacterial wilt but industrial production of its chlamydospores has been challenging. Researchers have optimized the liquid fermentation process using chlamydospore yield of strain HX2 as the key response indicator.
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NewsBeyond the gut: Necrotizing enterocolitis drives neurodevelopmental impairment through gut-derived inflammation
A severe gut disease in premature infants, known as necrotizing enterocolitis (NEC), does far more than damage the intestines—it fundamentally alters brain development, leaving up to 40% of survivors with lasting cognitive, motor, and behavioral impairments.
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