A researcher has used his AI-supported Sequence Display technology to expand the targeting abilities of CRISPR/Cas9, evolving several variants of a compact Cas9 that could efficiently target stretches of DNA previously inaccessible for editing. The evolved Cas9s were successfully used to edit two genes found in coronary heart disease.
New peer-reviewed research demonstrates a strong association between residual fetal bovine serum in oil-adjuvanted vaccines and the prevalence of “cross-stitch” vertebrae, a condition linked to significant growth reduction.
A vaccine candidate developed by scientists at the University of Oxford has been recommended to enter a pivotal Phase 2/3 clinical trial in the Democratic Republic of the Congo (DRC), in a significant step towards tackling Bundibugyo virus, a potentially deadly pathogen for which no vaccine is currently approved.
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A sugar naturally found in breast milk may help newborn intestines mature and process bilirubin, the compound that builds up during jaundice. In mice, loss of 3’-sialyllactose disrupted gut development, worsened hyperbilirubinemia and was linked to greater intestinal vulnerability later in life.
A recent study reveals how astroviruses use goblet cells as an escape route from the small intestines to evade host immunity and enhance spread and transmission, presenting a new path for treating pediatric diarrhea.
Researchers are uncovering how cattle genetics and rumen microbes work together to shape methane emissions and feed efficiency. The findings could support new feed additives, probiotics and microbial strategies that reduce emissions while helping cattle extract more energy from their diet.
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