All Infection Prevention & Control articles – Page 7
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Study links influenza A viral infection to microbiome, brain gene expression changes
Infection with influenza A is found to be associated with disruptions in newborn piglets’ nasal and gut microbiomes and with potentially detrimental changes in gene activity in the hippocampus, a brain structure that plays a central role in learning and memory.
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Herpes virus plays interior designer with human DNA
Researchers have discovered the cold sore virus reshapes the human genome’s architecture, rearranging its shape in three-dimensional space so that HSV-1 can access host genes most useful for its ability to reproduce.
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New vaccine works against multiple fungal infections
A vaccine developed by University of Georgia researchers successfully protects against and treats vaginal yeast infections in mice, according to a study.
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Scientists discover key protein that enables ‘shock & kill’ strategy for HIV latent virus clearance
Researchers have identified a specific gene transcription factor, BRD9, as a potential key to unlocking the mechanisms behind HIV-1 latency.
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Scientists discover a materials maze that prevents bacterial infections
Scientists have discovered surface patterns that can drastically reduce bacteria’s ability to multiply on plastics, which means that infections on medical devices, such as catheters, could be prevented.
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Immune ‘dysregulation’ present prior to infection predicts severe responses
A study shows that a common gene signature of immune health or dysfunction predicts severe outcomes from infection, and is present in people with known risk factors such as being a smoker or having a high body mass index, even before they encounter a pathogen.
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Launch of first-in-human clinical trial of next-generation rotavirus vaccine delivered via dissolvable microarray technology
Scientists have announced the first clinical trial of a novel rotavirus vaccine, CC24, delivered via dissolvable microarray technology, is now enrolling participants.
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Excessive use of disinfectants in intensive care patients may increase the risk of antibiotic-resistant infections
An international study has, for the first time, revealed a strong and direct link between the rise of antibiotic-resistant bacteria and universal disinfection procedures applied to patients in intensive care units.
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Study highlights role of jaundice-associated pigment in protecting against malaria
New research suggests that a pigment that causes yellowing of the skin, or jaundice, may help protect people from the most severe consequences of malaria.
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Oxymatrine, a quinoline alkaloid derived from Sophora flavescens, inhibits the Malassezia biofilm
Oxymatrine not only controls Malassezia overgrowth but also manages psoriasis symptoms, offering a dual-action mechanism for safer and more effective therapy, a new study shows.
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Researchers identify new llama-derived antibodies against current and future coronaviruses
Scientists have discovered a unique class of small antibodies that are strongly protective against a wide range of SARS coronaviruses, including SARS-CoV-1 and numerous early and recent SARS-CoV-2 variants.
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Epidemiological trends and serological profiles of respiratory pathogens in Guangzhou
A new study analyzing the epidemiological trends of multiple respiratory pathogens in Guangzhou, China, from 2013 to 2023, indicates the need for age- and gender-specific approaches to infection prevention and management.
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When bacteria get hungry, they kill – and eat – their neighbors
Scientists have discovered a gruesome microbial survival strategy: when food is scarce, some bacteria kill and consume their neighbors. The researchers show that under nutrient-limited conditions, bacteria use a specialized weapon — the Type VI Secretion System (T6SS) — to attack, kill, and slowly absorb nutrients from other bacterial cells.
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A combination of exercise and omega-3 reduces the severity of tooth root infections
Rats that exercised and took fatty acid supplements responded better to bacteria and the inflammatory process of apical periodontitis, which can occur when caries reach the root canal and cause an infection.
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New research reveals how bacteria export the building blocks of biofilms
Chemists examined how the polysaccharide “Pel” – a central component of many biofilms – is exported out of the cell by the pathogen P. aeruginosa and describe the structure of the so-called PelBC export complex, which represents the last station in the cell before “Pel” is released.
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Cultured mini-organs reveal the weapons of aggressive Shigella bacteria
Thanks to lab-grown miniature intestines, researchers have successfully mapped how aggressive Shigella bacteria infect the human gut. The study opens the door to using cultured human mini-organs to investigate a wide range of other serious infections.
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Scholars take a new look at controversial Stateville prison malaria research 75 years ago
Medical ethicists are shining a light on a buried part of the malaria research conducted on inmates at Illinois’ Stateville Penitentiary 75 years ago.
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Green light activates this antibiotic only where it’s needed
To make a more efficient antibiotic treatment, researchers have modified penicillin so that it’s activated only by green light. In early tests, the approach precisely controlled bacterial growth and improved survival outcomes for infected insects.
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Gifts from the sea: Molecules derived from coral may help fight harmful bacteria
Pus, strep throat, and even tuberculosis—most infectious diseases are characterized by a cluster of pathogenic bacteria that can be stubborn and resistant to antibiotics. Researchers have found another method to combat these bacteria using naturally sourced molecules found in corals.
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New research reveals a deadly fungal pathogen’s vulnerabilities
Scientists have disovered how the lethal pathogenic fungus, Cryptococcus neoformans, thrives, allowing them to identify potential novel therapeutic targets for treatment.