All Infection Prevention & Control articles – Page 5
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NewsResearchers develop new vaccine adjuvant that could make it easier to eradicate polio
Researchers have now come up with a way to modify the injectable polio vaccine so that it can also promote a mucosal immune response. This vaccine could help to achieve polio eradication while avoiding the risks of the oral polio vaccine.
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NewsStudy reveals core values that drive Black and Hispanic parents’ decisions on vaccinating their kids against COVID-19
Persistently low rates of COVID-19 vaccination in Black and Hispanic children suggest that parents in these communities tend to be hesitant about the vaccine for their kids, even when they have received it themselves. A new study sheds light on the factors influencing decisions about vaccination.
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NewsAntibiotics for common sore throats have very limited effect on Strep spread
Antibiotics for sore throats have hardly any preventive effect against serious streptococcal infections in the population, according to a study. Instead, healthcare needs to quickly recognize warning signs of a serious infection.
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News CEPI fast-tracks three Bundibugyo ebolavirus vaccine candidates
The Coalition for Epidemic Preparedness Innovations (CEPI) will urgently accelerate development of three investigational vaccines targeting the Bundibugyo ebolavirus that has caused a rapidly spreading epidemic in the Democratic Republic of the Congo (DRC) and neighbouring Uganda.
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NewsResearchers discover how to turn one germ’s drug resistance into an Achilles’ heel
As Mycobacterium tuberculosis mutates to protect itself from rifampicin, it also creates new weak points that other therapies could exploit. A new study shows that the most common rifampicin-resistance mutation slows bacterial RNA polymerase, creating vulnerabilities that future combination therapies may be able to target.
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NewsGladstone launches Center for PhAIge Therapy to harness AI in the fight against drug-resistant infections
Gladstone Institutes has received funding to establish the Center for PhAIge Therapy, a research center that will develop new phage-based treatments for antibiotic-resistant bacterial infections. The five-year grant makes Gladstone one of three institutions across the country selected to lead this coordinated effort.
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NewsT cells may be key to stopping measles virus—and its deadly relatives
Scientists have discovered how T cells target paramyxoviruses, a viral family that includes measles virus and Nipah virus. Instead of vaccinating against one virus at a time, the researchers found that activating “cross-reactive” T cells may protect against the wider paramyxovirus family.
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NewsBiomaterial made from jackfruit latex is a promising treatment for periodontitis
Researchers have developed a biomaterial containing jackfruit latex, pomegranate peel extract, and simvastatin that shows promising efficacy in treating periodontitis. This chronic inflammatory disease of infectious origin leads to the progressive destruction of the tissues supporting the teeth, resulting in bone resorption and loss of attachment.
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NewsStudy identifies serious infection risks linked to targeted cancer therapies
A major real-world study has found serious blood-related side effects associated with antibody-drug conjugates, an increasingly important class of targeted cancer therapies. Some ADCs were associated with substantial rates of severe neutropenia – dangerously low levels of infection-fighting white blood cells – and related complications.
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NewsPhase 1 clinical trial set to begin on first leishmaniasis vaccine
A phase 1 clinical trial testing the safety of a leishmaniasis vaccine is set to begin in the coming months. The live vaccine, found to be safe in animals, is expected to be tested in humans later this year.
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NewsNew study identifies key warning signs for infection after ankle fracture surgery in older patients
A new study of which patients are most at risk of a fracture-related infection post ankle surgery finds that low protein levels in the blood is the single strongest patient-related risk factor, making infection nearly 18 times more likely. Chronic alcohol abuse and failure to follow post-operative instructions each raise the risk more than fivefold.
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NewsZinc deficiency promotes fluconazole-resistant Candida auris virulence
Researchers identified key nutritional and genetic factors that drive the virulence of fluconazole-resistant Candida auris. Under zinc-deficient conditions, these drug-resistant strains gain a fitness advantage, exhibiting increased pathogenicity and resistance to macrophage-mediated killing.
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NewsHow Chinese cabbage fights downy mildew
Researchers focusing on the Brassica rapa–Hyaloperonospora parasitica pathosystem identifies DM459 as an Arg–x–Leu–Arg (RXLR) effector that interacts with BraATG8i, activates autophagy, stimulates salicylic acid (SA) signaling, and enhances resistance to downy mildew.
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News‘Accidental’ discovery lays foundation for novel flu treatment strategies
Scientists investigating how influenza viruses replicate within cells “accidentally” discovered that different flu viruses use distinct strategies to infiltrate cells in the first place. They also found that it is possible to target specific molecules to prevent the viruses from entering new cells, thereby stopping their replication.
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NewsEngineered gut bacteria therapy emerges as scalable potential alternative to fecal microbiota transplants following clinical trial
Researchers have developed a new manufacturing platform for producing targeted mixtures of beneficial gut bacteria, an approach that could help expand access to microbiome-based therapies for patients with recurrent Clostridioides difficile (C. difficile) infection.
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NewsReal-time brain monitor detects infections earlier
A research team has created a new monitoring system to save lives and significantly reduce health-care costs in brain-injury cases through the early detection of infections in intensive care units. NeuroSense connects to drainage lines to detect biomarkers of infection.
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NewsPan-European One Health Network established to bolster infectious disease response
iiCON: the Infection Innovation Consortium has successfully secured funding from COST to establish a unique pan-European COST Action network with over 70 collaborators from 21 countries and international organisations to harmonise the European response to infectious disease threats.
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NewsBehind the diagnosis: How laboratory testing guided a complex histoplasmosis case
A diagnosis of histoplasmosis forced a teenager with juvenile arthritis onto an uncertain path, one defined by months of treatment, recovery, and a long-term course of antifungal therapy expected to last up to three years. Histoplasma capsulatum, a dimorphic fungus that causes histoplasmosis, found its way into her lungs.
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NewsPost-discharge antibiotics may offer limited benefit after pediatric appendicitis
Acute appendicitis is one of the most common surgical emergencies among children, and complicated acute appendicitis (CAA), including perforated or gangrenous disease, carries a higher risk of infection and longer hospitalization. While intravenous antibiotics during hospitalization are standard practice, the role of oral home antibiotics (OHA) after discharge remains controversial. ...
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NewsPrecigen presents new long-term durability data for PAPZIMEOS, recently granted seven-year market exclusivity
Precigen, Inc. has announced updated long-term follow-up data from the pivotal study of PAPZIMEOS™ (zopapogene imadenovec-drba) for the treatment of adults with recurrent respiratory papillomatosis (RRP).