All Infection Prevention & Control articles
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Cohort data from Denmark show real-world evidence of stable protection against HPV-related cervical cancer
Denmark has been offering free vaccination against human papillomavirus (HPV) to girls since 2008. New data show vaccination has effectively reduced infections with cancerogenic HPV 16/18 types covered by the vaccine, indicating population immunity.
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Researchers develop mRNA-based vaccine against a deadly plague-causing bacterium
Researchers have used the platform developed for COVID-19 vaccines to create the world’s first mRNA-based vaccine against the deadly, antibiotic-resistant bacterium behind pneumonic plague.
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Scientists ID new drug target for treating cancer and viral infections
An international team of researchers has identified a molecular mechanism that regulates the activity of N-myristoyltransferases, enzymes that ensure the proteins’ function by chemically modifying them during their production.
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New strategy developed to engineer high-affinity receptor-containing antibodies against malaria
Researchers have introduced an innovative approach to developing high-affinity receptor-containing antibodies in vitro, offering a promising strategy to combat malaria.
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Structure of tick-borne virus revealed at atomic resolution for the first time
One emerging tick-borne virus in North America is the Powassan virus (POWV), which can cause encephalitis, seizures, paralysis and coma. Rates of POWV infections have increased in recent years and currently, there are no treatments available.
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Study reveals negative consequences of trained immunity in the lungs
Exposure to a common fungal molecule can reprogram immune cells in the lungs, causing them to overreact to infection-like signals and worsen lung damage, according to new research.
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Comprehensive review sheds light on rare blood clotting syndrome linked to COVID-19 vaccines
A new analysis has provided critical insights into the rare but serious condition known as vaccine-induced immune thrombotic thrombocytopenia (VITT). The findings confirm a higher risk of arterial and venous thrombosis after COVID-19 infection compared to vaccination.
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Vanderbilt and Parse Biosciences collaborate on new measles treatment
Vanderbilt University Medical Center and Parse Biosciences, an innovator in single-cell sequencing, are collaborating on a new treatment to help unvaccinated measles victims, as the U.S. measles outbreak has now reached its highest case count in 30 years.
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New study suggests Florida has the potential for local Chagas disease transmission
Researchers in Florida have discovered local kissing bugs are harboring the parasite that can lead to Chagas disease, demonstrating that this rare, chronic disease has a secure foothold in the U.S. and warrants more preventative measures.
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Clinical trials reveal promising alternatives to high-toxicity tuberculosis drug
Research shows two novel antibiotics could spare patients from severe side effects. The drugs sutezolid and delpazolid have demonstrated strong antimicrobial activity and a notably better safety profile compared to linezolid.
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Low dose of hydroxychloroquine is associated with reduced COVID-19 mortality: study
A new study provides observational evidence that low-dose hydroxychloroquine is associated with reduced COVID-19 mortality in hospitalized patients, particularly those with severe illness, when administered within the first week of symptoms.
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Researchers develop AI tool to detect surgical site infections from patient-submitted photos
Researchers have developed an artificial intelligence (AI) system that can detect surgical site infections (SSIs) with high accuracy from patient-submitted postoperative wound photos, potentially transforming how postoperative care is delivered.
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New breakthrough uncovers how to kill ‘zombie’ TB cells resistant to antibiotics
Researchers exposed a library of over 500,000 genetically modified tuberculosis bacteria to two commonly used antibiotics. By analysing the survivors, they pinpointed genes whose disruption significantly reduced the number of surviving persisters.
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Scientists find flawed data in recent study relevant to coronavirus antiviral development
A new study shows why scientists still don’t know how the NiRAN domain works. The findings could have sweeping implications for drug developers already working to design antivirals based on flawed assumptions, and underscore the importance of rigorous validation.
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T cells take aim at Chikungunya virus
A new study offers the first-ever map of which parts of Chikungunya virus trigger the strongest response from the body’s T cells, bringing researchers closer to developing Chikungunya vaccines or therapies that harness T cells to strike specific targets to halt infection.
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World’s first AI system for single-tooth prediction of early childhood caries detection with over 90% accuracy
Scientists have developed the world’s first artificial intelligence (AI) system capable of predicting early childhood caries risk for individual teeth based on microbial characteristics, achieving an accuracy rate of over 90%.
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Study reveals engineered bacterial vesicles to combat antimicrobial resistance
Researchers studying extracellular vesicles (EVs)-membrane-bound nanoparticles released by cells that transport biologically active molecules like proteins or nucleic acids have engineered EVs derived from lactic acid bacteria to carry pathogen-specific endolysins on their surface.
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Vaccination support program reduces pneumonia-related mortality by 25 per cent among the elderly
Findings based on efforts in Sera Town, Japan showed the pneumococcal vaccination support program reversed the previously increasing trend in pneumonia mortality rate in the community.
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The gut’s secret weapon: viruses that heal
A comprehensive new review reveals how gut viruses interact with gut bacteria and host immunity, highlighting their roles in conditions like inflammatory bowel disease, colorectal cancer, and C. difficile infection. The findings offer a compelling case for harnessing the virome in novel therapies to reshape gut ecology and restore health.
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Study yields new insights into infection strategy of Pseudomonas aeruginosa
Scientists have uncovered a previously unknown trick used by Pseudomonas aeruginosa - the bacterium can functionally organize itself in diverse ways within a population of identical clones, as if it were not just one germ, but many at once. A mechanism of epigenetic memory preserves the activity of certain genes across generations.