All Microbial Genetics articles – Page 2
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NewsEndogenous retroviruses promote early human zygotic development
New findings offer insight into why some embryos fail to develop past zygotic genome activation (ZGA), pointing to an unexpected root of human infertility.
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NewsPlant discovery could lead to new ways of producing medicines
Scientists studying a plant called Flueggea suffruticosa, which produces a particularly powerful alkaloid known as securinine, investigated how this chemical is made - and discovered that the process is driven by a gene that looks more like it comes from bacteria than from a plant.
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NewsChanges in genetic structure of yeast lead to disease-causing genomic instabilities
Researchers studying a yeast model have discovered that the loss of heterochromatin can kickstart genetic changes, potentially resulting in the development of diseases like cancer.
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NewsCRISPR discovery could lead to single diagnostic test for COVID, flu, RSV
Researchers report newly discovered details about the Cas12a3 immune system that precisely targets transfer RNA in invading pathogens, without destroying host cells.
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NewsStudy identifies a molecular switch that controls transitions between single-celled and multicellular forms
How did multicellular life evolve from single cells? Researchers have identified genes in marine yeast that may help answer this fundamental question.
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NewsCandida auris: genetic process revealed which could be treatment target for deadly fungal disease
Scientists have discovered a genetic process which could unlock new ways to treat a mysterious and deadly fungal infection which has shut down multiple hospital intensive care units.
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NewsResearch reveals how ancient viral DNA shapes early embryonic development
New research focuses on a viral transposable element called MERVL. This element becomes highly active for a short window of time when a mouse embryo reaches the 2-cell stage – the point at which a fertilised egg has divided into two cells and switches on its own genome for the first time.
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NewsSmarter tools for peering into the microscopic world
In a pair of new studies, researchers introduce powerful tools that make it easier, more accurate and more scalable to figure out how microbes are related. One tool improves how scientists build microbial family trees. The other provides a software foundation used worldwide to analyze biological data.
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NewsAlgae show how to make two proteins from one messenger RNA
Scientists have uncovered a hidden feature of protein translation in green algae, offering a new perspective on the basic rules of gene expression.
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NewsAll life copies DNA unambiguously into proteins. Archaea may be the exception.
A study shows how a methane-producing member of the Archaea, interprets one three-letter sequence — normally a stop codon that signals the end of a protein — in two different ways, synthesizing two different proteins seemingly at random, though biased by conditions in the environment.
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NewsSingle-celled organisms found to have a more complex DNA epigenetic code than multicellular life
Researchers discovered that in more ‘primitive’ unicellular organisms, both the adenine and the cytosine bases are methylated. This would suggest that in some ways, these unicellular organisms are more complex than their multicellular peers.
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NewsMap of bacterial gene interactions reveals potential drug targets
Researchers have developed a new technique called Dual transposon sequencing (Dual Tn-seq), which allows for rapid identification of genetic interactions. It maps how bacterial genes work together, revealing vulnerabilities that could be targeted by future antibiotics.
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NewsFungi set the stage for life on land hundreds of millions of years earlier than thought
New research indicates the diversification of fungi hundreds of millions of years before the emergence of land plants. It suggests a common ancestor of living fungi dating to roughly 1.4–0.9 billion years ago.
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NewsHow viruses build perfectly symmetrical protective shells
Researchers used a new simulation framework to capture key biological factors like protein diffusion, genome flexibility, and shape-shifting behavior to model how viral proteins self-assemble into symmetric shells.
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NewsEngineered gut bacteria improves survival outcomes in colorectal cancer tumors
A genetically modified Salmonella typhimurium strain can colonise tumours and release a therapeutic protein, LIGHT, to induce the formation of mature tertiary lymphoid structures (mTLSs) in laboratory models.
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NewsHPV integration: Moving from carcinogenesis mechanisms to clinical applications
The clinical significance of HPV integration into the host genome is substantial, particularly in cervical cancer screening programs. Integration testing has emerged as a valuable triage tool for detecting high-grade cervical intraepithelial neoplasia (CIN III+).
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NewsHow HIV enters the genome – researchers identify previously unknown mechanism
Researchers have decoded a previously unknown mechanism by which HIV-1 selects its integration targets in the human genome. A research team identified RNA:DNA hybrids (R-loops) as molecular signposts for the virus.
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NewsTargeted delivery of microRNA sponge short-hairpin RNA via VIR-inspired biotechnical vector
The Vir-inspired Biotechnical Vector (VIBV) is a novel hybrid platform that combines viral and non-viral elements with nanotechnology to enable personalized, tumor-specific gene therapy.
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NewsWar, trade and agriculture spread rice disease across Africa
Since the mid-1800s, human activities have rapidly facilitated the spread of rice yellow mottle virus (RYMV), a pathogen that infects rice, far and wide across Africa, according to a new study.
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FeaturesGenome sleuths: using DNA to trace the evolution of animal-to-human pathogens
Zoonotic spillovers have become a significant focus of global health, with outbreaks like SARS and COVID-19 underscoring how quickly these events can escalate into worldwide crises. Genomics is crucial in tracing the origins and predicting the emergence of zoonotic threats.