All Proteomics & Enzymology articles – Page 4
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NewsWater-soluble version of bacterial enzyme may help researchers develop new antibiotics
Researchers created a water-soluble version of an important bacterial enzyme, which can now be used in drug screens to identify new antibiotics.
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NewsScientists unveil hepatitis B virus core protein as a Rab-GAP suppressor driving liver disease progression
In liver cells under oxidative stress, HBV core protein (HBc) perturbs mitochondrial dynamics and prevents cellular recycling of damaged mitochondria, thereby driving liver disease progression, a new study finds.
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NewsNew, modified CRISPR protein can fit inside virus used for gene therapy
Researchers have developed a novel version of a key CRISPR gene-editing protein that shows efficient editing activity and is small enough to be packaged within a non-pathogenic virus that can deliver it to target cells. Hongjian Wang and colleagues at Wuhan University, China, present these findings May 23rd in the ...
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NewsResearchers may have come up with second chance for antibiotic agent
A new study focuses on the protein peptide deformylase (PDF), which is involved in protein maturation processes in bacterial cells. While the original drug candidate had to be discarded, modification of the molecule could offer a second chance.
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NewsBioengineered enzyme creates natural vanillin from plants in one step
Researchers have developed an enzyme which can convert ferulic acid from plant waste into vanillin – the classic vanilla flavored compound.
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NewsEnzyme that reproduces Meinwald reaction offers hope as bionanomachine for green chemistry
Researchers have for the first time precisely characterised the enzyme styrene oxide isomerase, which can be used to produce valuable chemicals and drug precursors in an environmentally friendly manner.
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NewsResearchers may have found an Achilles heel for Hepatitis B
Researchers have revealed never-before-seen mechanisms that may lead to new therapeutic approaches for HBV.
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NewsTransfected SARS-CoV-2 spike DNA suppresses cancer cell response to chemotherapy
Researchers have examined the interaction between SARS-CoV-2 spike, p53 and MDM2 (E3 ligase, which mediates p53 degradation) in cancer cells using an immunoprecipitation assay.
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NewsDiscovery of bacterial proteins that induce asexual reproduction in insects
From microbes in the human gut to symbiotic algae in coral reefs, research in recent decades has increasingly revealed the pivotal roles that microorganisms (or microbial species) play in shaping the biology of host organisms and of broader ecosystems. For example, some endosymbionts—microbes that live within the cells of a ...
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NewsResearchers uncover key biomolecule involved in whooping cough infection
Researchers have identified a new complex-carbohydrate biomolecule, or glycan, that plays a key role in the nasal colonization of the Bordetella bacteria responsible for whooping cough.
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NewsResearch uncovers a new path to drug diversity
By exploring protein evolution, scientists have found new “fusion sites” that enable faster and more targeted drug development.
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NewsMembrane-producing enzyme offers promising target
The enzyme LpxC, which catalyzes the first irreversible step in the biosynthesis of the outer membrane of Gram-negative bacteria, is a highly promising target for the development of antibiotics.
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NewsMutation linked to neurological disorders delivers double-pronged attack at cellular level
A mutation linked to neurological disorders knocks out not just one protein involved in translating the genetic code, but the entire cellular translation machinery. That’s the discovery of a team from the University of Maryland who were investigating how editing defects in threonyl-tRNA synthetase (ThrRS) work at ...
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NewsDiscovery opens new possibilities for maximizing nitrogenase’s potential
Researchers have discovered two essential electron carriers which play a key role in determining the performance of iron (Fe) nitrogenase, thus opening up new possibilities for elucidating and maximizing nitrogenase’s potential.
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NewsAI provides the most complete map of interactions key to bacterial survival
Researchers have produced the most complete map of the bacterial essential interactome, i.e. how proteins combine and interact to perform functions essential for their survival.
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NewsDNA particles that mimic viruses hold promise as vaccines
Using a DNA-based scaffold carrying viral proteins, researchers created a vaccine that provokes a strong antibody response against SARS-CoV-2.
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NewsViral protein fragments may unlock mystery behind serious COVID-19 outcomes
‘Zombie’ virus fragments continue to cause inflammation after the virus is destroyed, a new study finds.
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NewsScientists uncover how coronavirus defends itself against our immune system
A research team identifies “protective switches” in the protein of the SARS-CoV-2 virus.
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NewsProtein may be the ‘glue’ that helps COVID virus stick
A study found that perlecan LG3 – a protein most commonly found in blood vessels and the brain – readily formed a stable bond with the COVID spike protein and perhaps enhanced the virus’ ability to bind with cells.
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NewsScientists make COVID receptor protein in mouse cells
Initially motivated to make receptor-based sensors and therapies for COVID-19, scientists develop general strategy for producing other complex proteins.