All Proteomics & Enzymology articles – Page 3
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NewsProtein interplay offers insights into how the immune system recognizes viral RNA
A new study reveals how two proteins cooperate in a key early step of antiviral detection. Using cryo-electron microscopy and high-speed atomic force microscopy, researchers found that LGP2 binds to viral RNA and recruits MDA5 molecules, as if threading beads on a string.
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NewsScientists identify key protein that stops malaria parasite growth
An international team of scientists have identified a unique protein essential for the malaria parasite’s survival and transmission. Aurora-related kinase 1 (ARK1) acts as a ‘traffic controller’ during the parasite’s unusual cell division and growth process.
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NewsHidden architecture inside cellular droplets reveals new targets for cancer and neurodegeneration
Cells rely on biomolecular condensates to coordinate essential biological processes without surrounding membranes. Scientists long assumed condensates lacked internal organization and functioned as a simple liquid, but a new study has discovered that some are built from intricate networks of thread-like protein filaments.
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NewsNew insights into how bacteria control DNA synthesis open the door to next generation antimicrobials
A new study combines structural biology, biophysical characterisation and functional assays to delineate how the bacterial transcriptional regulator NrdR’s quaternary structure responds to different nucleotide states and how these changes affect its regulatory activity.
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NewsA ring to transcribe them: The unique path of poxviruses
A study shows for the first time the mechanical elegance with which the viral protein VITF-3 controls the transcription process. Vaccinia viruses, the most widely studied model viruses from the poxvirus family, were examined at the molecular level.
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NewsExposing a hidden anchor for HIV replication
Scientists investigating HIV have revealed a previously unknown role for the viral protein integrase, which helps HIV insert itself into human DNA. A new study provides the first direct evidence that integrase plays a critical structural role earlier on in HIV’s life cycle — when the virus matures into an infectious force.
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NewsHow bacteria may promote breast cancer
Researchers have discovered how certain pathogenic bacteria in gut and breast tissue can promote breast cancer development and progression by hijacking a key metabolic enzyme known as spermine oxidase (SMOX).
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NewsA yeast enzyme helps human cells overcome mitochondrial defects
An international team has experimentally uncoupled nucleotide synthesis from mitochondrial activity using ScURA, a yeast-derived genetic tool now available to the research community that will enable new explorations of cellular metabolism.
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NewsLiving material makes harmful UV light visible – Functional coating made from proteins and bacteria
Researchers have developed a T-shirt coating - using proteins and bacteria - that reliably detects contact with UV-A radiation, is bio‑based, and could open the door to a wide range of new materials that draw on the biological functions of cells.
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NewsHow the joint defence mechanism of two bacteria works
Back in 2021, researchers showed that bacteria of the genera Pseudomonas and Paenibacillus join forces to protect themselves from their predator, an amoeba. Now, they have been able to show exactly how this defense mechanism works.
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NewsWhat drives a mysterious sodium pump?
The enzyme Na⁺-NQR is a sodium pump that drives the respiration of many marine and pathogenic bacteria, powering the transportation of sodium ions across the membrane. A new study found that the sodium pump changes its structure in response to electron transfer inside the protein.
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NewsResearchers enable microorganisms to build molecules with light
Researchers are continually looking for new ways to hack the cellular machinery of microbes to make useful products. A new study shows they can expand the biosynthetic capabilities of these microbes by using light to help access new types of chemical transformations.
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NewsResurrected ancient enzyme offers new window into early Earth and the search for life beyond it
By resurrecting a 3.2-billion-year-old enzyme and studying it inside living microbes, researchers have created a new way to improve our understanding of the origins of life on Earth. The study uses synthetic biology to reverse-engineer modern enzymes and rebuild their possible ancestors.
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NewsScientists engineer quantum-enabled proteins, opening a new frontier in biotechnology
A new study reports the creation of a new class of biomolecules, magneto-sensitive fluorescent proteins, that can interact with magnetic fields and radio waves. This is enabled by quantum mechanical interactions within the protein, and occur when it is exposed to light of an appropriate wavelength.
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NewsReconstructing nature’s oxindole factory: yeast-based biosynthesis of medicinal indole alkaloids
By identifying four key enzymes from a North American plant and reconstituting them in yeast, scientists have achieved complete de novo biosynthesis of complex oxindole molecules that are difficult to obtain from plants or chemical synthesis.
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NewsScientists develop new biosynthetic route to optically pure S-2-Hydroxyisovalerate
By uncovering an unexpected enzyme activity and combining it with precise metabolic engineering, scientists has transformed Escherichia coli into a microbial factory capable of producing gram-per-liter levels of optically pure S-HIV from renewable carbon sources.
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NewsWhat causes some people’s gut microbes to produce high alcohol levels?
A study of people with a rare condition known as auto-brewery syndrome has found a link between gut microbes and symptoms of intoxication, pointing to new treatment strategies.
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NewsNew findings on Candida auris open up potential targets for future therapies
A study shows for the first time that Candida auris uses a CO₂-based metabolic strategy to survive in the nutrient-poor conditions of the skin and to better tolerate antifungal therapies – especially amphotericin B.
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NewsAn enzyme neutralizes pathogens by cleaving a bacterial toxin
Researchers have discovered an enzyme that neutralizes the virulence factor malleicyprol in the bacterium Burkholderia pseudomallei, considered one of the most dangerous bacterial pathogens in the tropics.
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NewsBreakthrough AI speeds up discovery of life-supporting microbes
Scientists have developed a powerful new artificial intelligence tool called LA⁴SR that can rapidly identify previously overlooked proteins in microalgae - tiny organisms that produce much of the Earth’s oxygen and support entire aquatic ecosystems.