All Proteomics & Enzymology articles – Page 3
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NewsMicrobes contribute a surprisingly large array of proteins in fermented foods
A study examining the proteins found in fermented foods like yogurt, cheese and bread found that a surprisingly large number, and percentage, of microbial proteins contribute to their overall protein content.
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NewsScientists catch a fungal enzyme open for business
A new study shows that caspofungin, a widely used antifungal drug, works only when its target enzyme is active, pointing the way toward designing better treatments.
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NewsResearchers disable antimicrobial resistance in cystic fibrosis-associated bacteria
A newly discovered mechanism renders antibiotic-resistant bacteria vulnerable by disabling both their individual resistance and a process known as cross-protection, the ability of resistant bacteria to shield nearby, otherwise sensitive strains.
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NewsNew research reveals cell proteins that drive severe viral infections
Researchers have identified two human cell proteins, NUP98 and NUP153, that play a crucial role in how viruses such as tick-borne encephalitis virus (TBEV), West Nile virus, and dengue virus replicate in the body.
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NewsBlood test using artificial intelligence paves the way for early diagnosis of leprosy
A new blood test combined with a standardized questionnaire and artificial intelligence may transform the way leprosy is diagnosed in Brazil. The method showed potential for identifying the disease in its initial stages, when symptoms are subtle and traditional laboratory tests often fail.
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NewsNipah virus hijacks host protein NSUN2 to fuel replication
Researchers have decoded a critical survival strategy of the deadly Nipah virus (NiV), identifying a key host protein hijacked by the pathogen and translating this discovery into a promising new treatment approach.
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NewsSoil bacteria break down toxic chemicals in the environment
Soil bacteria can help to break toxic aromatic compounds down. For one of these, Rhodococcus opacus 1CP, researchers have analyzed the genome and identified many potential metabolic pathways that the bacterium can employ to act as a ‘clean-up specialist’.
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NewsScientists solve 40-year-old biological mystery behind sleeping sickness
Scientists have cracked a 40-year-old biological cold case by revealing how the parasite that causes sleeping sickness stays one step ahead of the human immune system.
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NewsResearchers move closer to preventing pandemics
Researchers have developed an AI tool that can help determine whether unfamiliar bacteria carry genetic features linked to disease. By enabling the detection of harmful bacteria before they infect humans, this could transform pandemic preparedness.
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NewsFluorescent imaging reveals how a global parasite develops, opening new paths for drug treatment
Researchers adapted a fluorescent imaging system typically used to study human cells, enabling real-time observation the parasite’s growth, a promising breakthrough against an organism that that infects both humans and animals.
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NewsFantastic fungi found with ability to freeze water
An international group of researchers has discovered the identity of fungal proteins that can catalyze ice formation at high subzero temperatures. One potential application of this discovery could be to engineer weather.
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NewsTargeting two flu proteins sharply reduces airborne spread
A study in ferrets — which have remarkably similar respiratory systems to humans — suggests that immunity to two proteins in the H1N1 influenza virus sharply reduces transmission.
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NewsStudy writes the catalog of plasma membrane repair proteins
A new study identifies 80 proteins involved in plasma membrane repair in budding yeast, laying the foundation for membrane repair studies and future therapeutic applications.
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NewsHerpes virus fluidizes cell nuclei to multiply faster
A new study finds that herpes simplex virus uses a protein called infected cell protein 4 (ICP4) to make the human nucleus more fluid-like, which in turn makes it easier for the virus to replicate itself. Blocking the ability of ICP4 to fluidize the nuclear compartment caused a drop in viral copy production.
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NewsA highly precise target for medications against tropical diseases
Researchers have discovered a critical vulnerability shared by the pathogens that cause African sleeping sickness, Chagas disease and leishmaniasis. The PEX38 protein plays a crucial role in the formation of certain organelles of the trypanosomes that are essential for their energy supply.
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NewsProtein interplay offers insights into how the immune system recognizes viral RNA
A new study reveals how two proteins cooperate in a key early step of antiviral detection. Using cryo-electron microscopy and high-speed atomic force microscopy, researchers found that LGP2 binds to viral RNA and recruits MDA5 molecules, as if threading beads on a string.
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NewsScientists identify key protein that stops malaria parasite growth
An international team of scientists have identified a unique protein essential for the malaria parasite’s survival and transmission. Aurora-related kinase 1 (ARK1) acts as a ‘traffic controller’ during the parasite’s unusual cell division and growth process.
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NewsHidden architecture inside cellular droplets reveals new targets for cancer and neurodegeneration
Cells rely on biomolecular condensates to coordinate essential biological processes without surrounding membranes. Scientists long assumed condensates lacked internal organization and functioned as a simple liquid, but a new study has discovered that some are built from intricate networks of thread-like protein filaments.
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NewsNew insights into how bacteria control DNA synthesis open the door to next generation antimicrobials
A new study combines structural biology, biophysical characterisation and functional assays to delineate how the bacterial transcriptional regulator NrdR’s quaternary structure responds to different nucleotide states and how these changes affect its regulatory activity.
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NewsA ring to transcribe them: The unique path of poxviruses
A study shows for the first time the mechanical elegance with which the viral protein VITF-3 controls the transcription process. Vaccinia viruses, the most widely studied model viruses from the poxvirus family, were examined at the molecular level.