All Proteomics & Enzymology articles – Page 2
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NewsDigital model guides cleaner biohydrogen production
A research team has developed an enzyme-aware digital model that explains why hydrogen-producing microbes often struggle to grow fast and generate hydrogen efficiently at the same time. The study reveals how limited enzyme resources shape the balance between cell growth, by-product formation, and hydrogen generation.
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NewsHow are chloroplasts communicating with the nucleus? Bacterial enzymes show the way
By utilizing bacterial enzymes that cleave heme molecules at different sites, researchers have developed a method to dissect phytochrome-dependent light and heme retrograde signaling pathways in plants, which have previously been difficult to discuss separately.
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News‘Accidental’ discovery lays foundation for novel flu treatment strategies
Scientists investigating how influenza viruses replicate within cells “accidentally” discovered that different flu viruses use distinct strategies to infiltrate cells in the first place. They also found that it is possible to target specific molecules to prevent the viruses from entering new cells, thereby stopping their replication.
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NewsRedesigning an elusive bacterial enzyme into an efficient green catalyst
Scientists engineer the CYP107J1 enzyme from Bacillus subtilis into a more practical tool for selective oxidation chemistry.
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NewsWhat is the link between HIV and chronic pain?
A mouse study reveals a mechanism linking HIV to chronic pain. Targeting each of the molecular players in this mechanism alleviates pain and may hold treatment promise for HIV-associated pain, though more work is needed.
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NewsResearchers discover tick protein that may block disease transmission
Researchers have found that ticks produce an exosomal glycine-rich protein that plays a vital role in helping ticks feed and transmit viruses. When they used genetic tools to silence the gene responsible for this protein, ticks lacking the protein struggled to feed effectively and showed reduced body weight after feeding.
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NewsOrangutans breastfeed their young for six and a half years, the longest among mammals
Researchers show that wild orangutan juveniles keep consuming their mother’s milk continuously until at least six and a half years of age. The study also suggests that the more milk a juvenile consumes, the stronger its biological defenses and the higher the presence of probiotic intestinal bacteria.
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NewsA common disinfectant could affect how well your liver works
Common household cleaners and pharmaceutical products contain benzalkonium chlorides (BACs), a type of disinfectant. A new study shows that exposure to these compounds caused changes in gut microbiome composition in mice, as well as the genes that encode for liver enzymes that metabolize drugs.
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NewsAs day turns to night, blue-green algae undergo a molecular rewiring
Traditionally, biotechnology researchers have modified genes when engineering microbes. But researchers are using predictive phenomics to uncover additional layers of biological control, tracking how environmental changes reshape molecular activity inside a cell and how those shifts translate to function.
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NewsProtein engineering and testing condensed to a single day
Engineered proteins must be created in the real world and tested for performance - a labor-intensive process that involves constructing the DNA instructions for each protein in yeast or bacteria and growing individual clones for protein production and testing. Researchers say they have condensed the time-intensive protein building and testing process to just 24 hours.
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NewsNo refrigeration needed for killer disease vaccine
Malaria kills more than half a million people every year, but a new vaccine is showing promise as it not only offers long-lasting strong protection but also inhibits transmission of malaria by mosquitos. The vaccine is predicted to be low cost and its cold-chain independence strongly enhances its deployability.
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NewsAnti-CRISPR stops the protein assembly line in bacteria
Bacteria fend off invading viruses with molecular scissors that slice up viral DNA, but viruses can fight back with a molecular trick that stops the scissors from ever being made. A viral “anti-CRISPR” protein sits on the ribosome and jams it as a CRISPR protein named Cas12 begins to form.
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News‘Atomic snapshots’ of proofreading enzyme could lead to better COVID-19 drugs
A research team used images generated by a cryogenic electron microscope (cryo-EM) to observe the interplay between SARS-CoV-2 proofreading enzyme exoribonuclease (ExoN) and RNA incorporated with antivirals such as remdesivir, sofosbuvir and bemnifosbuvir.
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NewsStudy uncovers new kind of cold sensor
Investigators studying a bacterial protein have identified a new mechanism of sensing cold temperatures. The finding points to the possibility that this same type of mechanism exists in other organisms, including humans, and may have relevance for disorders involving faulty temperature regulation.
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NewsResearchers identify potential new route for antimalarial drug design
Researchers have uncovered a promising new potential target for drug discovery. The team focused on an enzyme called aminopeptidase P (PfAPP) from Plasmodium falciparum, the parasite responsible for the most severe form of malaria in humans.
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NewsFungi utilize ancient antimicrobial proteins to attack hosts and their microbiomes
An international research team has discovered the surprising evolutionary origin of fungal effector proteins: molecules that pathogens use today to infect their hosts appear to have evolved from ancient antimicrobial proteins.
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NewsPolymer ‘bristles’ could help repel proteins — and germs — from surfaces in medical settings
A non-toxic coating made of polydimethylsiloxane prevents proteins from sticking to surfaces — potentially offering a new tool in the fight against hospital-acquired infections.
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NewsJ. Craig Venter, genomics pioneer and founder of JCVI and Diploid Genomics, Inc., dies at 79
The J. Craig Venter Institute (JCVI) has announced that J. Craig Venter, Ph.D., the Institute’s founder, board chair, and chief executive officer, died in San Diego following a brief hospitalization for unexpected side effects that arose from treatment of recently diagnosed cancer.
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NewsResearchers uncover three families of ‘sponge’ proteins deployed by phages
Using an innovative research approach that combines artificial intelligence with experimental biology, researchers have uncovered new families of sponge proteins in phage genomes that disrupt immune communication in bacteria.
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NewsIn mice, viruses gain virulence in some individuals, depending on genetics and sex
New research demonstrates that some hosts appear to serve as “evolutionary accelerators” that could enable viruses to gain virulence more quickly.