All Proteomics & Enzymology articles – Page 2
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Scientists unveil how the oceans’ most abundant bacteria impact global nutrient flows
A new paper has revealed how key bacterial proteins contribute to global carbon, sulfur and other nutrient cycles.
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Extreme microbe reveals how life’s building blocks adapt to high pressure
An AI tool has helped scientists discover how the proteins of a heat-loving microbe respond to the crushing conditions of the planet’s deepest ocean trenches, offering new insights into how building blocks of life might have evolved under early Earth conditions.
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Scientists close in on mystery of deadly Hep C virus
A new study by a cross-disciplinary research team has identified the protein complex at the surface of the hepatitis C virus that enables it to bind to human cells, opening a pathway to vaccine candidates that can prevent the virus from infecting the cells.
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Study of mosquito spit could lead to therapies for viruses like West Nile and yellow fever
Researchers are analyzing samples of noninfectious mosquito saliva in the fight against arboviruses — viruses spread by arthropods like mosquitoes.
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Surprise find in study of environmental bacteria could advance search for better antibiotics
In what they labeled a “surprising” finding, researchers studying bacteria from freshwater lakes and soil say they have determined a protein’s essential role in maintaining the germ’s shape.
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Researchers find promising new weapon against certain types of antibiotic-resistant bacteria
Researchers have discovered a new combination of substances that appears to combat a range of bacteria that causes conditions such as stomach ulcers and urinary tract infections, and that are increasingly developing antibiotic resistance.
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Study reveals oleoyl-ACP-hydrolase underpins lethal respiratory viral disease
Respiratory infections can be severe, even deadly, in some individuals, but not in others. Scientists have gained new understanding of why this is the case by uncovering an early molecular driver that underpins fatal disease.
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Marine algae use massive enzymes of unprecedented size to biosynthesize fish-killing toxins
Marine algae Prymnesium parvum use massive enzymes dubbed PKZILLAs – some of the largest proteins ever to be identified in nature – to make large and complex prymnesin neurotoxins responsible for mass fish kills during harmful algal blooms worldwide.
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Scientists get to the bottom of COVID’s worst pediatric complication
Scientists investigating multisystem inflammatory syndrome in children (MIS-C) found their immune systems had latched onto a part of the coronavirus that closely resembles a protein found in their bodies, launching an attack on their own tissues.
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Enzyme discovery could lead to anti-bacterial pesticides targeting plant disease
Researchers investigating Xanthomonas plant pathogens have identified XccOpgD, a glycoside hydrolase (GH186) that plays a pivotal role in the biosynthesis of CβG16α, which suppresses essential plant defense mechanisms.
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Study identifies protein that affects health of gut microbiota and response to bacterial infection
A new study shows how the presence of a specific protein called IL-22BP affects the composition of the gut microbiota and the body’s response to bacterial infection.
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Phage-derived enzyme targets biofilms to mitigate acute graft-versus-host disease
Scientists investigating acute graft-versus-host disease probe gut microbiome to detect presence of a bacteriophage-derived enzyme known as endolysin, exhibiting potent antibacterial activity specifically targeting E. faecalis.
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Scientists isolate amylase enzyme produced by indigenous bacteria from sugar factory waste
Experts in wastewater processing and treatment have isolated amylase-producing bacteria from the liquid waste of sugar local factories and optimized the production of the amylase enzyme.
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Degradation of cell wall key in the spread of resistance
A new study shows how an enzyme breaks down the bacteria’s protective outer layer, the cell wall, and thus facilitates the transfer of genes for resistance to antibiotics.
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Water-soluble version of bacterial enzyme may help researchers develop new antibiotics
Researchers created a water-soluble version of an important bacterial enzyme, which can now be used in drug screens to identify new antibiotics.
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Scientists unveil hepatitis B virus core protein as a Rab-GAP suppressor driving liver disease progression
In liver cells under oxidative stress, HBV core protein (HBc) perturbs mitochondrial dynamics and prevents cellular recycling of damaged mitochondria, thereby driving liver disease progression, a new study finds.
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New, modified CRISPR protein can fit inside virus used for gene therapy
Researchers have developed a novel version of a key CRISPR gene-editing protein that shows efficient editing activity and is small enough to be packaged within a non-pathogenic virus that can deliver it to target cells. Hongjian Wang and colleagues at Wuhan University, China, present these findings May 23rd in the ...
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Researchers may have come up with second chance for antibiotic agent
A new study focuses on the protein peptide deformylase (PDF), which is involved in protein maturation processes in bacterial cells. While the original drug candidate had to be discarded, modification of the molecule could offer a second chance.
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Bioengineered enzyme creates natural vanillin from plants in one step
Researchers have developed an enzyme which can convert ferulic acid from plant waste into vanillin – the classic vanilla flavored compound.
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Enzyme that reproduces Meinwald reaction offers hope as bionanomachine for green chemistry
Researchers have for the first time precisely characterised the enzyme styrene oxide isomerase, which can be used to produce valuable chemicals and drug precursors in an environmentally friendly manner.
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