All Research News articles – Page 14
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Antibodies that recognize lipids: A new path for HIV vaccines and autoimmune disease treatments
Scientists have used computer modeling to illustrate how a specific class of antibodies actually use lipids to recognize the HIV virus. The work highlights antibody features that could help people design better vaccines for HIV and autoimmune diseases.
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Scientists uncover the link between ‘good’ gut bacteria and rheumatoid arthritis
After spending years tracing the origin and migration pattern of an unusual type of immune cell in mice, researchers have shown how activity of “good” microbes in the gut is linked to rheumatoid arthritis and, potentially, other autoimmune diseases.
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Monoclonal antibody nirsevimab provides strong protection against severe RSV in infants
Nirsevimab, a monoclonal antibody, is highly effective in real-world conditions at preventing severe respiratory syncytial virus (RSV) infections in infants, suggests a meta-analysis.
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A symbiotic gut fungus wards off liver disease in mice
Researchers have found a new ally in the fight against a serious liver disease: a symbiotic gut-dwelling fungus that produces a molecule shown to be capable of reversing disease progression in mice.
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Designer microbe shows promise for reducing mercury absorption from seafood
Scientists who inserted DNA-encoding methylmercury detoxification enzymes into the genome of an abundant human gut bacterium found it detoxified methylmercury in the gut of mice and dramatically reduced the amount that reached other tissues.
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Study of facial bacteria could lead to probiotics that promote healthy skin
Researchers have revealed the dynamics of interactions between two dominant skin bacterial species in more detail than previously possible, shedding light on when and how new bacterial strains emerge on the skin of the face.
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Bacterial villain behind Lake Erie’s ‘potent toxin’ unveiled by study
In Lake Erie, cyanobacteria can proliferate out of control, creating algal blooms that produce toxins that can harm wildlife and human health. Researchers have IDed the organism responsible for the toxins: a cyanobacteria called Dolichospermum.
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Protein sources change the gut microbiome – some drastically
A new study shows that protein sources in an animal’s diet can have major effects on both the population and function of the gut microbiome. The two largest effects of dietary protein were on amino acid metabolism and complex sugar degradation.
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Bacteria deployed as living test tubes to study human gene mutations
Bioengineers have developed a new simple approach to rapidly check on human gene changes and also screen chemicals as potential drugs by turning everyday bacteria into living test tubes.
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New AI technique can uncover antiviral compounds using limited data
Artificial intelligence algorithms have been combined with traditional laboratory methods to uncover promising drug leads against human enterovirus 71 (EV71), the pathogen behind most cases of hand, foot and mouth disease.
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Herpesvirus protein mimics host enzyme to balance infection and latency
Researchers have uncovered a novel regulatory mechanism of CDK mimicry that may help herpesviruses coexist and expand within host cells while balancing host survival with viral persistence throughout the host’s lifespan.
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Long COVID biomarkers found – associated with respiratory problems
Researchers have identified biomarkers in the blood associated with symptoms of long COVID, particularly severe respiratory disorders. The discovery can pave the way for future diagnosis and treatment.
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siRNA plus nanovaccine yields stable functional cure for chronic hepatitis B
Researchers have developed an innovative therapy for chronic hepatitis B, synergistically combining their proprietary ferritin nanoparticle-preS1 (Ferritin-NP-preS1) therapeutic vaccine with a preclinically validated HBV-specific siRNA.
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Cutting off parasite’s energy supply could help fight malaria
Once inside the body of an infected person, the malaria parasite relies on a process called glycolysis to produce energy and stay alive. Blocking the enzymes involved in this process could cut off the parasite’s primary energy source and kill it.
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Bacteria use ancient war trick to outsmart viruses – and it could help us fight superbugs
Scientists have discovered a new type of immune defense in E. coli bacteria that turns viral infection machinery against the virus itself. They’ve named it Kongming after the Chinese military strategist who famously used enemy weapons to defeat his foes.
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Novel compound inhibits the growth of tumor-associated Fusobacteria
Researchers seeking ways to eliminate fusobacteria in carcinomas have made an unexpected discovery: their control compound, FUS79, which did not target a specific transcript, exhibited strong activity against five fusobacterial strains without affecting other tested bacterial species.
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New study reveals emerging cases of babesiosis in Mid-Atlantic region
A newly published study provides critical insights into the emergence of babesiosis in the Mid-Atlantic region, documenting human cases and the presence of Babesia microti in local tick populations.
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Pediatric investigation review discusses the challenges, innovations, and future directions in dengue vaccine development
A new review discusses the current status and implications of dengue vaccines like CYD-TDV, TAK-003, and Butantan-DV while exploring the challenges in Dengue vaccine development like ADE, and proposes future directions in this field.
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Chiral phytovirucide targets viral Nia protein to inhibit proliferation
A new study focuses on the search for small molecules to target the Nia protein of Potato virus Y (PVY), one of the most economically destructive viruses affecting Solanaceous crops such as potatoes, peppers, and tomatoes.
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Researchers reveal how human genetics and intratumoral microbiota affect colorectal cancer
A study shows that the single-nucleotide polymorphism (SNP) rs2355016—a tiny DNA change that some people carry—affects how intratumoral microbiota adhere to tumor cells, promoting colorectal cancer progression.