All Pharmaceutical Microbiology articles – Page 25
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News‘Subway map’ of Lyme disease pathways IDs potential treatment targets
Researchers have developed a genome-scale metabolic model of key metabolic activities of the bacterium that causes Lyme disease, successfully identifying two compounds that selectively target routes only used by Lyme disease to infect a host.
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NewsYeast speeds discovery of medicinal compounds in plants
Researchers have harnessed the power of baker’s yeast to create a cost-effective and highly efficient approach for unraveling how plants synthesize medicinal compounds, and used the new method to identify key enzymes in a kratom tree.
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NewsResearchers probe >10,000 drug combinations to beat AMR
In an extensive investigation, researchers have tested over 10,000 drug combinations against some of the leading pathogenic bacteria carrying antimicrobial resistance and causing mortality.
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NewsAlert immune system in respiratory tract protects children from severe Covid
Scientists have discovered that the immune system in the upper respiratory tract is much more alert and active in children before infection than in adults and is therefore better equipped to fight the virus.
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NewsNovel enzyme family could provide insights into bacterial pathogenicity
Researchers discover a new family of Gram-negative bacterial enzymes related to infection capability.
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News‘Remarkable’ medical discovery for sepsis moves to next phase of human trials
Florey researchers, working with hospital intensive care clinicians, have shown that sodium ascorbate – a pH-balanced formulation of vitamin C – is effective in treating sepsis.
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NewsNovel biomaterial delivers medication directly to fish gut
In addition to helping combat antimicrobial resistance, the bioparticle avoids the waste and pollution created by excessive amounts of drugs in water bodies.
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NewsStudy IDs six drugs that can be repurposed for treatment of toxoplasmosis
Brazilian researchers screened 160 compounds known to be effective against SARS-CoV-2 and identified those that also act against the protozoan parasite Toxoplasma gondii.
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NewsResearchers developing an oral therapeutic to treat drug-resistant bacterial pneumonia
Australian researchers aim to rescue common antibiotics with a new therapeutic approach, using a drug originally developed to treat neurodegenerative disorders.
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NewsVersatile vaccine candidate fights measles, mumps and Covid
Altered measles and mumps viruses could be used as a platform to create a trivalent COVID-19 vaccine that triggers immunity to multiple variant strains of the SARS-CoV-2 virus, new research in animals suggests. The study builds upon previous studies that involved inserting a highly stable segment of ...
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NewsSRI spins off AI-powered drug discovery platform Synfini, Inc
SRI International has announced it is spinning off Synfini, a biosciences platform that accelerates the process by which pharmaceutical and other companies can design, synthesize, and bring to market molecules for drug development.
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NewsAntibiotics can help some bacteria survive for longer
Scientists have found a surprising effect of some antibiotics on certain bacteria – that the drugs can sometimes benefit bacteria, helping them live longer.
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NewsResearchers pioneer safe chemotherapy methods for treating bacterial infections
Antibiotic resistant bacteria are a threat to human lives, and yet the development of new drugs to treat bacterial infections is slow. A group of proven drugs used in cancer treatment for decades could possibly be the solution. A new class of antibiotics is now being developed by researchers at ...
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NewsAntiviral drug linked to SARS-CoV-2 mutations
Researchers have uncovered a link between an antiviral drug for COVID-19 infections called molnupiravir and a pattern of mutations in the SARS-CoV-2 virus.
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News Fast-track strain engineering for speedy biomanufacturing
The time and money required to engineer microbes to produce vital medicines and chemicals can be dramatically reduced with a new model-based method.
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NewsBlood cancer drug shows promise in killing ‘silent’ HIV cells
An existing blood cancer drug has shown promise in killing ‘silent’ HIV cells and delaying reinfections – a significant pre-clinical discovery that could lead to a future cure for the disease.
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NewsNewly engineered versions of bacterial enzyme reveal how antibiotics could be more potent
Researchers have generated the full inventory of mutations in the bacterial species Escherichia coli where the antibiotic rifampicin attaches to and disables an essential bacterial enzyme known as RNA polymerase (RNAP).
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NewsResearch uncovers possible monoclonal antibody treatment for Lassa fever
New research potentially points to an effective treatment for Lassa fever, a dangerous, often fatal disease common to much of West Africa but considered a major threat to global health.
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NewsCargo system inhibits E.coli biofilms with a fraction of the antibiotic dose
Scientists have designed a bacteria-targeted cargo system that is capable of inhibiting a quinolone resistant Escherichia coli biofilm using much lower levels of antibiotic. The researchers, from Koç University School of Medicine in collaboration with College of Science, Department of Chemistry, encapsulated the antibiotic ciprofloxacin into superparamagnetic iron oxide nanoparticles ...
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NewsResearchers decode new antibiotic clovibactin
Researchers have discovered and deciphered the mode of action of a new antibiotic, clovibactin, which is derived from a soil bacterium.