All Antimicrobial Resistance articles – Page 9
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NewsJumbo phages deploying secret handshakes could usher in new antibiotics
Jumbo phages create a restricted space inside bacteria where they can copy their DNA while surrounded by a protective shield. A new study reveals that the shield works via a set of ’secret handshakes’, allowing only a specific set of useful proteins to pass through.
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NewsPersister act: Why antibiotics can fail even against non-resistant bacteria
A new study challenges the concept that persisters are the cause of antibiotic ineffectiveness, demonstrating that standard laboratory tests of antimicrobial clearance produce misleading results, giving a false impression of a small group of particularly resilient persisters.
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NewsNew phage platform pinpoints viruses that can deliver a knockout blow for killer bacteria
An international group of microbial experts has launched a powerful and flexible free online genomic toolkit for more rapid development of phage therapy. They say it is capable of assessing if a phage is suitable for a targeted therapy in under 10 minutes.
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NewsRising threat of carbapenem-resistant Enterobacteriales (CRE) spurs urgent healthcare alert
The deteriorating epidemiological situation of carbapenem-resistant Enterobacteriales (CRE) has spurred ECDC to alert EU/EAA countries to the importance of controlling the spread of CRE infections to safeguard their healthcare systems.
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CareersSummer studentship: Ojewale finds novel Actinomycetes offer rare antimicrobial metabolites
Ojewale Ifeoluwa Florence reports back on her AMI-sponsored summer studentship which focused on the investigation of Actinobacteria found in local freshwater environments in Ogun State, Nigeria, under supervisor Dr. Amina Badmos.
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NewsNew method offers faster response to new virus variants
Researchers present a promising approach for swift identification of mutations that are crucial for the immune escape that enables the rapid adaptation of vaccines to new virus variants. It is based on a previously established method called mutational scanning.
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NewsAntibiotics of the future are prone to bacterial resistance
Two studies have found that resistance can develop against new antibiotics even before they are widely used, compromising their effectiveness from the start. The studies focused on five critical bacterial species and examined 18 new antibiotics.
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NewsStudy finds three new safe, effective ways to treat drug-resistant tuberculosis
An international clinical trial has found three new safe and effective drug regimens for tuberculosis that is resistant to rifampin, the most effective of the first-line antibiotics used to treat TB.
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NewsResearchers identify genetic ‘fingerprint’ to predict drug resistance in bacteria
To avoid antibiotic overuse and allow precise bacterial infection treatment, particularly against bacteria with multidrug resistance, a diagnostic tool was developed that identifies the pattern of DNA repair deficiencies acting as the bacterial antibiotic resistance ‘fingerprint’.
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NewsCARB-X funds Rhode Island Hospital to assess feasibility of direct from blood detection of bacterial pneumonia
Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator (CARB-X) will award Rhode Island Hospital at Brown University Health US$1M to demonstrate proof-of-concept of a polymerase chain reaction (PCR) approach informed by RNA sequencing to detect bacterial pneumonia directly from whole blood.
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NewsNew study uncovers mechanisms of bacterial dormancy involving protein aggregation
Researchers have revealed a mechanism involving protein aggregation that allows bacteria to enter a dormant state, a phenomenon that is associated with the persistence of infections and the challenge of antibiotic resistance.
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NewsNovel nanoreactor CU@G - AMPs: A promising solution for antibacterial therapy
A novel sustainable antibacterial therapy - an antibiotic-free complex, Cu@G-AMPs, has been developed by a team of Chinese scientists to combat drug-resistant bacteria such as MRSA.
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NewsV-161: A breakthrough in the fight against antibiotic-resistant VRE infections
Researchers from Japan have identified V-161, a compound that inhibits Enterococcus hirae V-ATPase activity, disrupting Na+ transport and effectively inhibiting VRE growth.
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NewsCuriosity-driven experiment helps unravel antibiotic-resistance mystery
An international collaboration has achieved an important breakthrough in understanding the genetic mechanisms that allow bacteria to build resistance to drugs.
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NewsShorter, smarter, safer: Short-course antibiotics can revolutionize healthcare
Researchers suggest that short-course antibiotic treatment could be the next game-changing strategy to treat ventilator-associated pneumonia (VAP) in various economic settings. It provides a cost-effective and practical approach that benefits both patients and the healthcare systems.
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NewsAntibiotic treatment for drug-resistant tuberculosis found to be safe and effective in clinical trial
Two clinical trials were conducted to successfully test an oral antibiotic levofloxacin for the preventive treatment of multidrug-resistant tuberculosis (MDR-TB).
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NewsNew computer models open door to far more targeted antibiotics
A powerful computer-modelling approach has been developed to give the antibiotics a laser-like precision for targeting specific types of bacteria among specific parts of the human body.
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NewsCARB-X funds Melio to develop rapid diagnostic to detect neonatal sepsis
CARB-X will award biotechnology company Melio US$3.5M to develop and execute a technical feasibility workplan for its culture-free platform designed to identify blood stream infections including neonatal sepsis.
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NewsHow fungi strengthen their defenses - and how we could break through them
A research team has discovered that the enzyme Mod5 in the fungus Aspergillus fumigatus plays an important role in the modification of fungal tRNA and helps confer temporary antifungal resistance.
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NewsManure management in China cuts river antibiotic pollution but raises groundwater contamination risks
A study of antibiotic pollution patterns in China’s water systems over the past decade found a 59% decrease in antibiotic pollution in rivers, primarily due to reduced direct manure discharge, but antibiotic leaching into groundwater has increased by 15%.