All Microbial Genetics articles
-
NewsCRISPR map reveals 6,500 genetic interactions in tuberculosis bacteria
Researchers have created the most detailed map yet of how essential genes interact in Mycobacterium tuberculosis. By uncovering nearly 6,500 genetic relationships, the study reveals hidden gene functions and points to new ways of identifying drug targets and more effective antibiotic combinations.
-
NewsNew CRISPR proteins expand editing access to heart disease genes
A researcher has used his AI-supported Sequence Display technology to expand the targeting abilities of CRISPR/Cas9, evolving several variants of a compact Cas9 that could efficiently target stretches of DNA previously inaccessible for editing. The evolved Cas9s were successfully used to edit two genes found in coronary heart disease.
-
NewsCattle genetics and gut microbes could help cut methane emissions
Researchers are uncovering how cattle genetics and rumen microbes work together to shape methane emissions and feed efficiency. The findings could support new feed additives, probiotics and microbial strategies that reduce emissions while helping cattle extract more energy from their diet.
-
NewsA type of Arctic Ocean bacteria may be using acetone to turn carbon into food
A newly identified Arctic Ocean bacterium may have an unusual way of making the building blocks it needs to grow. Using acetone, a common chemical in seawater, the bacteria incorporate carbon dioxide (CO2) into their metabolisms, allowing them to survive in waters where nutrients and usable organic matter are scarce.
-
NewsCould newly identified gene targets help prevent and treat Salmonella infections?
Investigators identified three genes that are essential for biofilm formation in the foodborne bacterial pathogen Salmonella Typhimurium. Their experiments showed that disrupting these genes impaired biofilm structure and adhesion, and also resulted in decreased host colonization and virulence.
-
NewsAMI members call for microbiome-focused approach to EU biotechnology regulation
Members of Applied Microbiology International (AMI) have urged the European Commission to put microbial communities at the heart of environmental risk assessments for genetically modified microorganisms, as part of its response to the EU Biotech Act consultation.
-
NewsSimulator predicts jumping genes’ roles in changing genome size
Researchers have created a new computational tool that works from an inferred ancestral point and evolves forward to the modern-day genome to trace the insertion and deletion dynamics of these ’jumping genes’, known as transposable elements.
-
NewsNew AI tool helps scientists identify bacteria hidden in soil
A handful of soil holds a crowded world of bacteria, fungi and other organisms. Scientists can collect their DNA, but much of it remains difficult to identify. Now, researchers have developed an artificial intelligence tool that recognizes bacterial DNA in tiny genetic fragments, making it faster and easier to study the complex communities living in soil.
-
NewsScreening for putative essential genes in Brucella abortus strains A19 and S2308 using transposon mutagenesis
The categorization of functional genes in Brucella requires refinement. This knowledge gap was addressed by classifying gene essentiality through constructing a transposon mutant library. Mariner transposon mutant libraries were independently constructed for Brucella abortus A19 and S2308.
-
NewsTwo-in-one tool tracks viral RNA inside live infected cells in real time
The tool lets researchers film activity of Zika and chikungunya viruses in high resolution and identify virus-host interactions, a key step to developing effective antiviral strategies that could stop infections
-
NewsHow E. coli eavesdrops and senses Bifidobacterium
Gut bacteria may be quietly listening in on one another’s metabolism. Researchers have discovered that E. coli can detect chemical signals released by Bifidobacterium, allowing it to sense what nearby bacteria are doing and adjust its own metabolism in response.
-
NewsResearchers engineer more sensitive CRISPR tool for virus detection
Researchers have engineered a more sensitive version of the RNA-targeting CRISPR enzyme Cas13a, improving its detection performance by 100-fold without sacrificing stability. The tool could support faster and more adaptable tests for HIV and a wide range of other RNA viruses.
-
NewsAn unusual bacterial defence system hides a powerful molecular switch
Researchers have uncovered a bacterial immune system that appears to work backwards. Unlike known retrons, which keep a toxin suppressed until infection, type VI retrons use phage-triggered DNA production to switch toxin activity on, revealing an unusually complex defence strategy that could inspire new gene-editing tools and antimicrobials.
-
NewsBeetles build with a yellow pigment gene
More than 80 years ago scientists discovered that differences in yellow pigmentation were critical to courtship success and failure for fruit flies. New research has added a deeper perspective to the study of Yellow, showing how in tortoise beetles this protein has been co-opted as a building material to house symbiotic bacteria.
-
NewsScientists propose an endosymbiont-mediated framework for cryptic speciation in insects
Endosymbionts drive ecological divergence by conferring different physiological capabilities on hosts, providing the impetus for population differentiation under natural selection, a new paper suggests.
-
NewsGermany marks first CRISPR therapy success
A 19-year-old with severe beta-thalassemia has become the first patient in Germany to receive an approved CRISPR-based therapy as part of routine medical care. Four months after treatment at Charité, he no longer requires regular blood transfusions, marking a major step in bringing gene editing from the laboratory into everyday clinical practice.
-
NewsNew type of human jumping gene found in a poxvirus
Until now, no one has observed a human gene that is both mobile and required for bodily functions. Scientists have found a human genetic element in a poxvirus and discovered it was both an important gene for brain function and a jumping gene capable of moving and inserting itself in genomes.
-
NewsNabsys announces first publication showcasing CRISPR/Cas9 mediated approach to expand the capabilities of electronic genome mapping
This study is the first to demonstrate the potential of combining Electronic Genome Mapping (EGM) with CRISPR/Cas9 to both characterize CRISPR/Cas9 activity and enhance the capabilities of genome mapping.
-
NewsNew study uncovers how the malaria parasite boosts its transmission potential under stress conditions
Researchers reveal the molecular mechanism by which Plasmodium falciparum responds to stress by increasing the production of the sexual forms required for transmission.
-
NewsDeleting yeast DNA to save lives
People with weakened immune systems and some other conditions can experience an overgrowth of Candida yeasts, leading to a type of infection known as candidiasis. It might be possible to save these patients by using CRISPR to delete the very genes that let infectious Candida resist treatment - but which genes are responsible?