All Pharmaceutical Microbiology articles
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NewsCompound from Antarctic microorganism can be used to produce food, cosmetics, and medicine
A bioactive compound produced by the microorganism Bacillus licheniformis, found on Deception Island in Antarctica, has properties that qualify it for use in producing food, cosmetics, pharmaceuticals, and biodegradable materials.
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NewsCould targeted steroid use offer a universal complimentary treatment to fight TB?
Newly published research provides evidence that treating patients with steroids may enhance the function of their macrophages to kill the mycobacteria, while diminishing pathways of inflammatory damage.
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News‘Cocktails’ of common pharmaceuticals in our waterways may promote antibiotic resistance
New research has shown, for the first time, how mixtures of commonly used medications which end up in our waterways and natural environments might increase the development of antibiotic resistant bacteria.
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NewsStructural diversity of pyripyropenes via biosynthetic gene cluster design and heterologous expression in Aspergillus nidulans
Researchers have designed a reconstituted biosynthetic gene cluster (BGC) for producing structurally diversified deacetylated pyripyropenes, using the native pyripyropene A BGC from the wild-type strain Aspergillus fumigatus Af 293 as a template.
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NewsTraditional Chinese medicine combined with peginterferon α-2b in chronic hepatitis B
A new study demonstrates that adjunctive Traditional Chinese Medicine significantly enhances the antiviral efficacy of peginterferon α-2b in HBeAg-positive chronic hepatitis B while concurrently mitigating treatment-limiting myelosuppression.
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NewsScientists reveal role of paeoniflorin in mediating microbiota-gut-brain axis
Paeoniflorin treatment significantly reduced depression-like behaviours in stressed rats, while gut microbiota analysis revealed that the treatment corrected imbalances in key metabolites associated with brain function, a study shows.
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NewsSlime mold metabolites are a promising, eco-friendly repellent of root-knot nematodes
A team of researchers has discovered 14 compounds secreted by slime molds that repel root-knot nematodes (RKNs) - worm-like parasites of the genus Meloidogyne - and could be the source of new, non-toxic anti-RKN pesticides.
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NewsEngineered bacterial therapy activates immune response in cancer preclinical studies
Researchers have developed a new bacterial immunotherapy that delivers immune-activating proteins directly to solid tumors, which can often suppress the immune system. ACTM-838 targets phagocytic immune cells within the tumor microenvironment.
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NewsProtein nanorings designed to detect and neutralize SARS-CoV2 virus
Scientists have generated a new ring-shaped protein nanomaterial capable of strongly binding to and neutralising the SARS-CoV2 virus. The new nanomaterial is formed by a scaffold based on recombinant ring-like proteins (RLPs), to which mini proteins were incorporated.
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NewsIn a nasal spray, gold nanoparticles deliver a targeted treatment to the brain
In the form of a ‘nasal spray’, tiny gold particles act as carriers, delivering a treatment directly to the brain: a new nanotechnological device for the treatment and prevention of neuropsychiatric and neurodegenerative diseases and infections.
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NewsResearchers find key to stopping deadly infection
New research has identified a key step that enables rotavirus to infect cells. The researchers found that disabling the process in tissue culture and in mice prevented infection.
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NewsProfessor awarded $3.9 million to fight deadly parasites that threaten children and immunocompromised adults
A multi-institutional team will develop effective drugs that are urgently needed to manage cryptosporidiosis in young children, immunocompromised adults and as a countermeasure to epidemic outbreaks.
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NewsScientists blaze new path to fighting viral diseases
Scientists have identified a potential new drug against the virus that causes COVID-19 - and devised a powerful new platform for finding medicines to fight many types of infectious diseases. Compound 6, led SARS-CoV-2 viral proteins to misfold, malfunction, and ultimately, be destroyed and removed by cells, in lab tests.
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NewsAntibody discovered that blocks almost all known HIV variants in neutralization assays
An international research team has discovered an antibody that could advance the fight against HIV. The newly identified antibody 04_A06 proved to be particularly effective in laboratory tests. It was able to neutralize 98.5 percent of more than 300 different HIV strains, making it one of the broadest antibodies against HIV identified.
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NewsThe RESTART trial: a drug to block a toxic HIV molecule
What if the presence of a well-known but misunderstood viral protein explains why some people living with HIV (PLWH) never recover their health, even with antiretroviral treatment? Researchers will explore this in a groundbreaking clinical trial this fall.
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NewsSummer studentship: Shen explores how a novel peptide can destabilise the outer membrane of E. coli
Li Shen reports back on his AMI-sponsored summer studentship which investigated a novel antibiotic adjuvant at the Centre for Bacterial Resistance Biology, Imperial College London.
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NewsGenetic ‘Trojan horse’ selectively kills cancer cells linked to Kaposi’s sarcoma
A highly targeted gene therapy that could revolutionize treatment for cancers linked to a common herpesvirus harnesses an adeno-associated virus (AAV) to deliver a genetic “Trojan horse” into infected cells.
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NewsNew herpes virus–based vaccine could cure cancer in the future without side effects
The Herpes simplex virus is a widespread virus that often causes cold sores, and most people carry it. By removing a virulence gene, i.e. a gene that makes the virus harmful to humans, the herpes virus can be repurposed as a cancer vaccine.
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NewsPeptide study paves path toward new weapon against antibiotic-resistant bacteria
New research into antimicrobial peptides, small chains of amino acids able to damage bacterial cells, shows why some peptides are more effective at doing that and also why some cells are more vulnerable.
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NewsSummer studentship: Eoin probes medicine-microbiome interactions using in vitro gut model
Eoin McKernan reports back on his AMI-sponsored summer studentship which focused on the relationships between the gut microbiome and the metabolism of variable response drugs.