All Pharmaceutical Microbiology articles
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NewsNew antimicrobials could help tackle deadly drug-resistant infections
Scientists have developed a promising new way to create safer and more effective treatments for life-threatening fungal infections. Using genome mining, they identified bacterial species capable of producing new, undiscovered antifungals.
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NewsRemdesivir for COVID-19 linked to better outcomes for adult kidney transplant recipients
Adults with kidney transplants who were treated for COVID-19 with the antiviral remdesivir within a week of diagnosis were less likely than kidney transplant recipients who did not receive the antiviral to experience cardiovascular or kidney problems up to a year later.
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NewsBeyond antibiotics—a paradigm shift toward bacteria-control-centric therapies
A novel extracellular vesicle platform helps polymyxins kill multidrug-resistant gram-negative bacteria at lower and potentially safer doses.
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News A secret weapon against superbugs
A molecular library of potential adjuvants has been used to help restore the activity of vancomycin, a powerful antibiotic widely used to treat serious infections such as MRSA and Clostridium difficile (C. diff).
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NewsResearchers find a new way to tackle drug-resistant infections - starvation
A drug designed to block ECF transporters would attack the bacteria while leaving human cells largely unaffected, substantially reducing the risk of side effects. A research team has succeeded in developing exactly such a drug candidate.
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NewsLast-line antibiotics at risk as children’s resistance rises
Antimicrobial resistance in children is rising globally and will worsen over the next decade, threatening the effectiveness of life‑saving antibiotics, according to a world-first monitoring platform.
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NewsExpanding uses for bioengineered bacterial spores
Fused to the outer layer of bacterial spores, things like enzymes, biosensors, and drugs are easily stored under even extreme conditions.
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NewsNovel antifungal drug shows promise in some patients with Valley Fever
A study found that olorofim, a first-in-class orotomide antifungal agent, showed efficacy in patients with disseminated coccidioidomycosis (DCM), a rare complication of Valley Fever where the fungus spreads from the lungs to other parts of the body.
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NewsROS–Jak2/Stat3 signaling drives HBV-induced liver inflammation
Scientists investigated the mechanisms underlying HBV-induced liver inflammation and identified a reactive oxygen species (ROS)-dependent signaling cascade that activates the Jak2/Stat3 pathway, thereby triggering hepatic inflammatory responses.
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NewsGenetically engineered Bifidobacterium shows potential for oral delivery of cancer vaccines
A novel oral vaccine platform using genetically engineered Bifidobacterium could enhance anti-tumor immunity. In an exploratory phase I clinical study, the vaccine was well tolerated and generated immunologic and clinical findings that warrant further investigation.
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NewsFirst clinical proof of concept for ibuprofen as an adjunctive treatment for tuberculosis
Scientists have published the results of a phase IIa pilot clinical trial assessing ibuprofen as a host-directed therapy in patients with pre-extensively drug-resistant tuberculosis (pre-XDR-TB) and extensively drug-resistant tuberculosis (XDR-TB).
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NewsNew project ORIGIN aims to redefine how society accesses natural ingredients
The ORIGIN consortium will develop an integrated AI-supported platform designed to accelerate the path from natural molecules to sustainable, fermentation-based ingredients. The project aims to reduce development timelines to two to three years.
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NewsBrazil, Malaysia, and Thailand set to start global clinical trial to test promising dengue treatment
Following a licensing agreement signed between the Serum Institute of India (SII) and DNDi, a Phase III clinical trial is expected to begin early next year, with the aim of developing a safe, effective, and globally accessible therapeutic for dengue.
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NewsResearchers identify a marine bacterial enzyme that opens a new route to build bioactive compound libraries
A research team has provided new insight into HapC, an enzyme from the marine bacterium Hahella chejuensis. They used modified short-chain versions of one key chemical building block and examined whether HapC could join them with another precursor to form new prodiginine compounds.
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NewsGene-editing tool can unearth new cancer treatments from fungi
Engineers have developed a gene-editing tool built specifically for fungi, unlocking a hidden library of molecules—including some with early anti-cancer promise—from one of biology’s most overlooked kingdoms.
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NewsCommon COVID-19 drugs may pose hidden risks to marine life, study finds
A new study suggests that several drugs widely used during the COVID-19 pandemic can be toxic to marine organisms, even at relatively low concentrations. Five pharmaceuticals were tested on nauplii of the brine shrimp Artemia salina.
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NewsThe case for fewer antibiotics in joint replacement surgery
Infections are a leading cause of joint replacement failures, however a new study suggests prescription of an extended courses of antibiotics after patients leave the hospital may not be needed.
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NewsRice-grown chaga reveals genes behind valuable triterpenoids
New study links triterpenoid accumulation in Inonotus obliquus with rising expression of key biosynthetic genes, providing a genetic foundation for future work to improve sustainable production of Chaga-derived compounds.
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NewsBreakthrough for aquaculture: Oral vaccine protects fish from fatal nervous necrosis virus
A novel oral vaccine, that can be mixed into fish feed, provides an effective, practical and cost-effective method to protect fish from the highly deadly nervous necrosis virus.
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NewsBack in action: Researchers make drug-resistant bacteria vulnerable again
New findings show that disabling a single bacterial protein can restore vancomycin’s power against resistant bacteria – and point to a new strategy for overcoming antibiotic resistance.