All Pharmaceutical Microbiology articles – Page 3
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NewsInsights for future research and practical approaches in truncal acne
In a new study, researchers have systematically described the mechanisms of truncal acne, evaluated the methods and evaluated the mechanisms, targets, and pros/cons of several treatment products to guide clinical choices.
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NewsFlightpath Biosciences licenses microbiome-sparing antibiotic developed at Illinois
Flightpath Biosciences, Inc., has licensed a class of antibiotics developed at the University of Illinois Urbana-Champaign. The original antibiotic agent, lolamicin, effectively treated bacterial infections in animal models of disease without wiping out beneficial gut microbes.
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NewsClinical trials reveal promising alternatives to high-toxicity tuberculosis drug
Research shows two novel antibiotics could spare patients from severe side effects. The drugs sutezolid and delpazolid have demonstrated strong antimicrobial activity and a notably better safety profile compared to linezolid.
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NewsCancer-fighting herpes virus shown to be an effective treatment for some advanced melanoma
A genetically engineered herpes simplex virus, when combined with immunotherapy, reduces or eliminates tumors in one-third of clinical trial patients, according to a new study.
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NewsTiny antibody has big impact on deadly viruses
Researchers have discovered a strategy to neutralise two lethal viruses for which there is currently no approved vaccine or cure. The team identified the first ever nanobody to work against Nipah and Hendra, henipaviruses which have jumped from animals to people.
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NewsResearchers find compound that inhibits cutaneous HPVs
Researchers have identified a promising new compound that inhibits cutaneous HPV. In lab studies, the compound inhibited viral replication genes in cutaneous HPVs without damaging host cells.
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NewsMediterranean bacteria may harbor new mosquito solution
Researchers recently identified bacteria in Crete producing metabolites that quickly kill mosquito larvae in lab tests. The compounds might be useful for the development of new biopesticides, though developing the right formulations and delivery method remains a challenge.
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NewsNew breakthrough uncovers how to kill ‘zombie’ TB cells resistant to antibiotics
Researchers exposed a library of over 500,000 genetically modified tuberculosis bacteria to two commonly used antibiotics. By analysing the survivors, they pinpointed genes whose disruption significantly reduced the number of surviving persisters.
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NewsStudy reveals engineered bacterial vesicles to combat antimicrobial resistance
Researchers studying extracellular vesicles (EVs)-membrane-bound nanoparticles released by cells that transport biologically active molecules like proteins or nucleic acids have engineered EVs derived from lactic acid bacteria to carry pathogen-specific endolysins on their surface.
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NewsFirst systematic review finds gut-brain axis impacts treatment outcomes in bipolar patients
A new review suggests that there is a significant connection between the gut and brain in patients treated for bipolar disorder and that this affects the ways in which a patient responds to treatment.
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NewsStudy validates DenovAI’s platform for programmable de novo-designed protein therapeutics
Researchers introduce a new class of experimentally validated AI-driven protein design tools that have the potential to accelerate drug development.
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NewsIlluminated changes: Enhancing D-lactic acid output with UV irradiation
Researchers have developed a Komagataella phaffii (K. phaffii) yeast strain that can efficiently produce D-lactic acid, a raw material for pharmaceuticals and bioplastics, from methanol.
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NewsAI could accelerate protein engineering – key for developing new medicines
An AI approach developed by researchers from the University of Sheffield and AstraZeneca could make it easier to design proteins needed for new treatments.
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NewsLaunch of first-in-human clinical trial of next-generation rotavirus vaccine delivered via dissolvable microarray technology
Scientists have announced the first clinical trial of a novel rotavirus vaccine, CC24, delivered via dissolvable microarray technology, is now enrolling participants.
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NewsStudy highlights role of jaundice-associated pigment in protecting against malaria
New research suggests that a pigment that causes yellowing of the skin, or jaundice, may help protect people from the most severe consequences of malaria.
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NewsBroad-spectrum coronavirus drug developed through AI-enabled dynamic modeling
Multidisciplinary AI- and physics-driven modeling of the viral fusion process enables discovery of an orally available drug inhibiting infection with multiple coronaviruses.
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NewsResearchers discover protein necessary for SARS-CoV-2 to evade the body’s defenses
Researchers have identified a protein that plays a key role in helping SARS-CoV-2 hide from the body’s defenses by suppressing the production of viral double-stranded (dsRNA), leading to increased viral replication while limiting the body’s immune response.
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NewsEvolutionary model for antibiotic resistance reveals dose timing critical to care
The study that uses a “fitness seascape” to incorporate a patient’s dosage schedule into models that predict whether an infection will develop antibiotic resistance has found that inconsistent timing and missing early doses can lead to treatment failure.
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NewsGlobal action urgently needed to tackle antimicrobial resistance, experts warn
Scientists have called for urgent changes to the way new antibiotics are developed to address the growing problem of antimicrobial resistance (AMR). They outline the scientific, economic, and regulatory barriers that are slowing progress.
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NewsGreen light activates this antibiotic only where it’s needed
To make a more efficient antibiotic treatment, researchers have modified penicillin so that it’s activated only by green light. In early tests, the approach precisely controlled bacterial growth and improved survival outcomes for infected insects.