All Pharmaceutical Microbiology articles – Page 3
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NewsA digestive ‘treasure chest’ shows promise for targeted drug treatment in the gut
A new approach to drug design can deliver medicine directly to the gut in mice at significantly lower doses than current inflammatory bowel disease treatments.
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NewsA symbiotic gut fungus wards off liver disease in mice
Researchers have found a new ally in the fight against a serious liver disease: a symbiotic gut-dwelling fungus that produces a molecule shown to be capable of reversing disease progression in mice.
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NewssiRNA plus nanovaccine yields stable functional cure for chronic hepatitis B
Researchers have developed an innovative therapy for chronic hepatitis B, synergistically combining their proprietary ferritin nanoparticle-preS1 (Ferritin-NP-preS1) therapeutic vaccine with a preclinically validated HBV-specific siRNA.
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NewsCutting off parasite’s energy supply could help fight malaria
Once inside the body of an infected person, the malaria parasite relies on a process called glycolysis to produce energy and stay alive. Blocking the enzymes involved in this process could cut off the parasite’s primary energy source and kill it.
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NewsFungi dwelling on human skin may provide new antibiotics
Researchers have uncovered a molecule produced by yeast living on human skin that showed potent antimicrobial properties against a pathogen responsible for a half-million hospitalizations annually in the United States.
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NewsNew COVID-19 drug shows greater promise against resistant viral strains
A new standalone oral drug candidate has proven to be effective against Paxlovid-resistant COVID-19 strain in animal models. It works with low doses and cause no drug interaction-induced side effects.
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NewsAn antiviral chewing gum to reduce influenza and herpes simplex virus transmission
Researchers have used a clinical-grade antiviral chewing gum to substantially reduce viral loads of two herpes simplex viruses and two influenza A strains in experimental models. The chewing gum could also work against bird flu.
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NewsSome gut bacteria could make certain drugs less effective
Researchers discovered that gut bacteria can metabolize oral administered drugs that target G protein-coupled receptor (GPCR) and potentially other chemicals and food compounds, leading to impacts on the effectiveness of medication to patients.
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NewsYellow pigment from Streptomyces coelicolor offers potential weapon against breast cancer
A new study aims to explore the effect of a yellow pigment (OR3), from a new isolate of Streptomyces coelicolor JUACT03 on metastatic breast cancer.
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NewsSea buckthorn extract exerts anti-free radical, antibacterial and whitening effects on skin
Sea buckthorn flavonoids exhibited excellent antimicrobial, anti-inflammatory and whitening effects in a new study. The inhibitory effect of sea buckthorn flavonoids on Propionibacterium acnes were assessed by plate antibacterial assays.
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NewsBreakthrough as researchers discover new class of antibiotics
Researchers have identified a strong candidate to challenge even some of the most drug-resistant bacteria on the planet: a new molecule called lariocidin.
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NewsThe gut microbiota-metabolites-brain axis mediates social behavior dysfunction following anaesthesia
New research shows that the anaesthetic Sevoflurane (Sev) influences social functioning via the gut-brain axis, with microbiota-derived bile acids serving as critical mediators in this pathway.
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NewsResearchers achieve de novo biosynthesis of plant lignans using synthetic yeast consortia
Researchers have achieved the biosynthesis of the antiviral ingredient lignan glycoside in yeast Saccharomyces cerevisiae. By mimicking the spatial and temporal regulation of plant biosynthesis, they designed a system with obligated mutualism, enabling metabolic division of labor among different yeast strains.
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NewsNew study reveals a safer alternative for long-term hepatitis B treatment
Researchers have studied the effects of switching from long-term tenofovir disoproxil fumarate to the antiviral besifovir dipivoxil maleatein (BSV) in patients with chronic hepatitis B. Switching to BSV may improve patient kidney and bone health.
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NewsBreaking antibiotic-resistant bacteria’s protective shields opens door for immune system response
Researchers have made progress in uncovering how Streptococcus pneumoniae constructs its capsule, which serves as a protective shield. This capsule is a primary target for vaccine development.
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NewsAntibody-based therapy is several steps closer to treat lethal mucormycosis
A new paper discusses the use of monoclonal antibodies to target a key fungal cell surface protein, CotH, which enables the Mucorales fungus to invade human cells and cause mucormycosis, which has high mortality rates in people with weakened immune systems.
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NewsNew model predicts how bacteria navigate obstacles to spread
A scientist has developed the first analytical model for predicting how bacteria spread in environments filled with obstacles. This model will help inform strategies for curbing bacterial infections or for designing better drug delivery.
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NewsResearchers test new, more reliable method to detect chagas disease
Researchers have successfully tested a faster, more sensitive and reliable way to diagnose Chagas disease, a debilitating parasitic illness that affects approximately 6 million people worldwide.
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NewsSelective G6PDH inactivation for Helicobacter pylori eradication with transformed polysulfide
A new study highlights a novel mechanism of action driven by polysulfides, presenting a promising alternative strategy for combating H. pylori infections.
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NewsJapanese plant Daphne pseudomezereum yields anti-HIV daphnane diterpenoids
Scientists have discovered for the first time that Daphne pseudomezereum (commonly known as Onishibari) contains a substance inhibiting replication of human immunodeficiency virus (HIV).