All Pharmaceutical Microbiology articles – Page 10
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NewsStudy identifies ‘Achilles heel’ of drug-resistant pathogens
A study has found a highly vulnerable weakness in drug-resistant Mycobacterium tuberculosis, using a genetic platform to identify biological pathways in a drug-resistant strain of the bacterium that are highly sensitive to inhibition.
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NewsPotential single-dose smallpox and mpox vaccine moves forward
Scientists report on studies suggesting that the horsepox virus in the experimental vaccine is substantially more attenuated—and less likely to trigger a systemic infection—than the vaccinia virus used in the single-dose vaccine already approved by the FDA.
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NewsResearchers seek out shorter, simpler TB treatments
Scientists are working to develop treatment options for tuberculosis that require fewer pills, shorter treatment periods (ideally 2-3 months), and consist of 3-4 medications that reduce the risk of resistance while minimizing toxicity.
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NewsScientists assess efficacy of clinical drugs targeting SARS-CoV-2 main protease
A critical player in the virus’s life cycle is the main protease (Mpro), also known as NSP5 or 3CL protease, which plays a crucial role in the cleavage and maturation of SARS-CoV-2 proteins within the host cells.
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NewsNew bacterial toxins discovered: A key to fighting infections
Researchers have discovered a new group of bacterial toxins that can kill harmful bacteria and fungi, opening the door to potential new treatments. Found in over 100,000 microbial genomes, they can destroy the cells of bacteria and fungi without harming other organisms.
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NewsGenetic analysis of bacteria from humans and animals paves the way for new active ingredients
A research team has set itself the goal of finding natural products that can be used to treat non-infectious diseases by directly searching the bacteria that colonize humans and animals and play a role in the development of diseases.
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NewsBacterial vaccine shows promise as cancer immunotherapy
Researchers have engineered bacteria as personalized cancer vaccines that activate the immune system to specifically seek out and destroy cancer cells.
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NewsSymbiosis between bacteria and toxic bird yields discovery of new antimicrobials
A research team has identified two new classes of active substances with antimicrobial properties from bacteria that live in symbiosis with a toxic bird.
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NewsStudy identifies potential targets for treatment of visceral leishmaniasis
Discovery of a novel class of proteins that help regulate the parasite’s essential cellular functions could lead to the development of more effective drugs against the disease. More than 3,500 new cases are notified each year in Brazil.
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NewsSelfishness mechanism points way to optimizing inhibitors that fight antibiotic resistance
Resistance can be fought by targeting bacteria that are ’selfish’ with their antibiotic resistance tools, according to a new study.
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NewsZika virus offeres potential as treatment for brain cancer: review
Fourteen studies showed that Zika virus reduced cell viability, inhibited the growth and proliferation of glioma stem cells (GSCs), and decreased Bcl2 expression in central nervous system tumors, potentially enhancing chemotherapy and radiotherapy effects.
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NewsScientists discover series of SARS-CoV-2 mpro inhibitors for potential COVID-19 treatments
New research has identified a novel series of SARS-CoV-2 Mpro inhibitors that may lead to potential new COVID-19 treatments that, according to preclinical testing, effectively inhibits COVID-19 and synergizes with existing anti-COVID therapies.
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NewsTrials show common cold medication significantly improved symptoms in less than two days
Applied Biological Laboratories will present results of a clinical trial which showed Biovanta significantly improved common cold symptoms including sore throat, cough, runny nose, congestion, chills, and sneezing in less than two days.
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NewsRates of a tick-borne parasitic disease are on the rise
Cases of babesiosis increased 9% per year, on average, between 2015 and 2022 and nearly half were co-infected with another tick-borne illness such as Lyme disease, according to a new study.
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NewsStudy identifies potential novel drug to treat tuberculosis
A new study demonstrates that a novel semi-synthetic compound can be derived from natural compounds to produce potent activity against Mycobacterium tuberculosis, including multi-drug resistant strains.
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NewsPlant compound used in traditional medicine may help fight tuberculosis
A compound found in African wormwood — a plant used medicinally for thousands of years to treat many types of illness — could be effective against tuberculosis, according to a new study.
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NewsNew images of RSV may expose stubborn virus’s weak points
Using cryo-electron tomography, researchers have revealed details of molecules and structures essential to RSV’s form and function.
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NewsHigh-throughput modular click chemistry synthesis of catechol derivatives to target Covid protease
Researchers performed high-throughput synthesis of catechol derivatives from the bioactive catechol-terminal alkyne scaffold A4, by using modular click chemistry, in a bid to target the Covid virus’s 3C-like protease (3CLpro).
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NewsScientists design new drug to fight malaria
Scientists have designed a new drug against malaria and identified its mechanism of action. MED6-189 is effective against drug-sensitive and drug-resistant P. falciparum strains in vitro as well as in a humanized mouse model.
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CareersFarm gates and facial fungi: Tanu charts her journey towards commercialisation
AMI Global Ambassador for New Zealand Tanushree Gupta is bringing an antifungal product to market that will make a huge difference to the hundreds of farms affected by facial eczema - so here’s how it’s going.