All Pharmaceutical Microbiology articles – Page 7
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NewsResearchers discover how to turn one germ’s drug resistance into an Achilles’ heel
As Mycobacterium tuberculosis mutates to protect itself from rifampicin, it also creates new weak points that other therapies could exploit. A new study shows that the most common rifampicin-resistance mutation slows bacterial RNA polymerase, creating vulnerabilities that future combination therapies may be able to target.
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NewsBiomaterial made from jackfruit latex is a promising treatment for periodontitis
Researchers have developed a biomaterial containing jackfruit latex, pomegranate peel extract, and simvastatin that shows promising efficacy in treating periodontitis. This chronic inflammatory disease of infectious origin leads to the progressive destruction of the tissues supporting the teeth, resulting in bone resorption and loss of attachment.
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NewsStudy identifies serious infection risks linked to targeted cancer therapies
A major real-world study has found serious blood-related side effects associated with antibody-drug conjugates, an increasingly important class of targeted cancer therapies. Some ADCs were associated with substantial rates of severe neutropenia – dangerously low levels of infection-fighting white blood cells – and related complications.
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NewsResearchers evaluate NASA medication storage protocols
Researchers evaluated NASA’s medication handling practices, which currently call for removing medications from their original packaging and storing them in resealable plastic bags. The investigation found that active pharmaceutical ingredients degrade at a higher rate when stored in bags.
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NewsPrecigen presents new long-term durability data for PAPZIMEOS, recently granted seven-year market exclusivity
Precigen, Inc. has announced updated long-term follow-up data from the pivotal study of PAPZIMEOS™ (zopapogene imadenovec-drba) for the treatment of adults with recurrent respiratory papillomatosis (RRP).
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NewsHealth researchers call for support to develop pandemic prevention
The Vanderbilt Center for Antibody Therapeutics has received large-scale government grants and contracts to fund the discovery of human antiviral antibodies. The problem is the next step — finding corporate partners to develop the antibodies through human testing.
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NewsResearchers aim to improve access to high-quality research and biomanufacturing tools in resource-limited settings
Researchers have demonstrated the effectiveness of a suite of low-cost, portable biotechnology tools designed to improve access to laboratory research and diagnostics in resource-limited settings.
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NewsNovel therapeutic drug for tuberculosis is proposed using high-precision molecular simulation
Researchers have proposed a novel therapeutic agent for tuberculosis, using high-precision molecular simulation techniques. The proposed drug is anticipated to bind strongly to the drug-metabolizing enzyme cytochrome P450 (CYP).
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NewsNew antibiotic design could help treat drug-resistant infections
A new study has shown that antibiotics can be chemically redesigned so they are less easily removed by efflux pumps. This allows the antibiotic to remain inside the bacterial cell at higher concentrations, restoring its ability to kill bacteria even when resistance mechanisms are present.
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NewsGenetic engineering of cyanobacteria for the production of sulfated polysaccharide
Researchers have developed a novel strategy to genetically engineer bacteria for the production of sulfated polysaccharides. They demonstrated the successful transfer and functional integration of an entire gene cluster responsible for producing a sulfated polysaccharide known as “synechan.”
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NewsExperimental gene therapy shields brain from toxic protein damage
An experimental gene therapy could help protect the brain from the damage and cognitive decline linked to TDP-43-related proteinopathy, a type of neurodegeneration.
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NewsNew immune system enhancer extends COVID-19 vaccine protection reducing need for repeated boosters
Researchers demonstrated that pairing the original COVID-19 mRNA vaccine with an adjuvant extended the duration of the vaccine’s protection in mice from a few months up to two years. The combo also showed a more pronounced response against omicron viral components than the vaccine alone.
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NewsResearchers investigate soil microbes from around the world for new antibacterial drugs
A team of researchers is looking to nature to find microbes that can be used to create new antibiotics to treat the growing threat of drug-resistant bacteria. They will screen soil microbes from around the world to hunt for sources of new antibacterial drugs.
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NewsThe ocean’s pharmacy: scientists chart a new path for marine peptide drug discovery
A review surveys how new extraction, chromatography, and bioinformatics tools are accelerating the discovery of bioactive peptides from the sea. Researchers provide an integrated overview of how marine bioactive peptides are produced, purified, and evaluated, and how bioinformatics is reshaping the discovery pipeline.
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NewsTrial tests virus-immunotherapy combination for neuroendocrine tumors
A phase I clinical trial is testing whether a tumor-targeting virus can help immunotherapy work more effectively against aggressive neuroendocrine tumors that often resist treatment. The ongoing study has completed its first three dose levels with no severe treatment-related side effects reported to date.
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NewsMicrobiome insights may help predict immunotherapy benefit in kidney cancer
City of Hope researchers report that gut microbiome composition may influence how patients respond to immunotherapy combinations in metastatic renal cell carcinoma, pointing to a potential biomarker that could help guide treatment selection in the future. The microbiome is a rising focus at City of Hope, highlighted ...
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NewsPegylated interferon-based treatment improves response rates in immune-tolerant patients with chronic hepatitis B
A new study aimed to investigate the efficacy and predictive factors of a pegylated interferon (Peg-IFN)-based treatment strategy in IT patients with chronic HBV infection.
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NewsChemists use sea sponge bacteria to create new molecules for drug discovery
Chemists have synthesized new molecules derived from bacteria found in a Pacific Ocean sea sponge. They are the first to successfully synthesize two new marine natural products: tetradehydrohalicyclamine B and epi-tetradehydrohalicyclamine B.
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NewsProtein engineering and testing condensed to a single day
Engineered proteins must be created in the real world and tested for performance - a labor-intensive process that involves constructing the DNA instructions for each protein in yeast or bacteria and growing individual clones for protein production and testing. Researchers say they have condensed the time-intensive protein building and testing process to just 24 hours.
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NewsImplantable living materials autonomously deliver therapeutics using contained engineered bacteria
Researchers have introduced an implantable “living material” that contains bacteria that sense infections. It can release these therapeutic molecules on demand, while keeping them physically separated from the surrounding tissue.