All Pharmaceutical Microbiology articles – Page 7
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NewsPegylated interferon-based treatment improves response rates in immune-tolerant patients with chronic hepatitis B
A new study aimed to investigate the efficacy and predictive factors of a pegylated interferon (Peg-IFN)-based treatment strategy in IT patients with chronic HBV infection.
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NewsChemists use sea sponge bacteria to create new molecules for drug discovery
Chemists have synthesized new molecules derived from bacteria found in a Pacific Ocean sea sponge. They are the first to successfully synthesize two new marine natural products: tetradehydrohalicyclamine B and epi-tetradehydrohalicyclamine B.
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NewsProtein engineering and testing condensed to a single day
Engineered proteins must be created in the real world and tested for performance - a labor-intensive process that involves constructing the DNA instructions for each protein in yeast or bacteria and growing individual clones for protein production and testing. Researchers say they have condensed the time-intensive protein building and testing process to just 24 hours.
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NewsImplantable living materials autonomously deliver therapeutics using contained engineered bacteria
Researchers have introduced an implantable “living material” that contains bacteria that sense infections. It can release these therapeutic molecules on demand, while keeping them physically separated from the surrounding tissue.
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NewsInfluenza virus platforms: New hope for vaccines and cancer immunotherapy
Influenza virus is now being engineered to carry foreign genes and reduce virulence, serving not only for next-generation influenza vaccines but also as delivery vectors for heterologous antigens against other infections and cancers, supported by its ability to trigger robust mucosal and systemic immune responses.
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NewsProbiotic Lactobacillus rhamnosus CMU-pb-7 shows promise in alleviating diabetic nephropathy via antioxidative pathway
Rats with diabetic nephropathy treated with the probiotic strain Lactobacillus rhamnosus CMU-pb-7 showed marked improvements in general condition and serum biochemical profiles, including significant reductions in cholesterol, triglycerides, blood urea nitrogen, and serum creatinine.
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NewsResearchers develop promising drug candidate for control and elimination of malaria
Researchers have developed a novel chemical compound that shows promise for the treatment and prevention of malaria, one of the world’s deadliest diseases. T111 has the potential to become a single-encounter malaria drug that would simplify treatment and prevent relapses that drive ongoing transmission.
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NewsCRISPR system inhibits hepatitis E virus
Researchers have developed a novel antiviral concept - using the CRISPR/Cas13 system, they were able to specifically suppress the replication of the hepatitis E virus in human cells.
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NewsInvisible smart bug fights gum disease
Current treatments for periodontitis often fail because they cannot simultaneously eliminate stubborn bacterial biofilms and calm the runaway inflammation that follows. Now researchers have engineered a living bacterium that does both, in the right order.
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NewsScientists take crucial step in developing world’s first measles treatment
Scientists have characterized human antibodies capable of neutralizing measles virus. These antibodies bind to key sites on measles virus and prevent the virus from entering host cells.
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News‘Atomic snapshots’ of proofreading enzyme could lead to better COVID-19 drugs
A research team used images generated by a cryogenic electron microscope (cryo-EM) to observe the interplay between SARS-CoV-2 proofreading enzyme exoribonuclease (ExoN) and RNA incorporated with antivirals such as remdesivir, sofosbuvir and bemnifosbuvir.
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NewsNew kind of CRISPR could treat viral infection and cancer by shredding sick cells’ DNA
A new technology uses a relative of the CRISPR-Cas9 gene editing system to kill target cells. When activated by a specific, programmable genetic target, the Cas12a2 protein rips a cell’s genome apart. Researchers programmed Cas12a2 to kill virus-infected cells or cancer cells while leaving healthy cells untouched.
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NewsKey magic mushroom ingredient makes fish less aggressive and lazier
Psilocybin, the chemical compound in magic mushrooms, may reduce energetically costly social behaviors like aggressive swimming bursts, shows a study demonstrating the first evidence of a calming effect in fish.
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NewsDeath-defying protein found in tardigrades preserves synthetic cells
Researchers have shown how a tardigrade protein protects cell membranes, using the proteins to preserve synthetic cells that were dried out and rehydrated in the lab. The finding could lead to a way to store and transport “microfactories” for producing medicines and other biological products.
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NewsResearchers identify potential new route for antimalarial drug design
Researchers have uncovered a promising new potential target for drug discovery. The team focused on an enzyme called aminopeptidase P (PfAPP) from Plasmodium falciparum, the parasite responsible for the most severe form of malaria in humans.
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NewsWhy antibiotics may soon fail to curb the plague bacterium - and where we can find new strategies
A new review shows that while most infections caused by the Yersinia plague bacterium can currently be treated with antibiotics, concerns about rising antimicrobial resistance mean that we need to come up with new ways to disarm the bacteria instead of killing them.
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NewsStudy confirms effectiveness of medicinal plant against SARS-CoV-2 virus
A study has revealed that galloylquinic acids extracted from the leaves of Copaifera lucens Dwyer, a tree endemic to Brazil primarily found in the Atlantic Forest, have a multi-targeted effect against SARS-CoV-2, the virus that causes COVID-19.
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NewsAncient, insect-targeting bacterial toxin may have implications for human health, agriculture, and drug discovery
Scientists have identified and characterized a new class of Streptomyces-produced toxins that are very distantly related to the deadly toxin that causes diphtheria, a serious and contagious infection, in humans.
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NewsNew cellular target prevents hepatitis E infection
To replicate, a virus must first enter a host cell. In a recent study, the researchers specifically investigated host cell processes required for successful HEV infection. In doing so, they identified the enzyme PIKfyve as a crucial factor for viral entry.