All Pharmaceutical Microbiology articles – Page 4
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NewsLab identifies gap in malaria vaccines, added peptides can strengthen response
The two vaccines in use today rally the immune system against a single region of the malaria parasite. A new study finds that adding short peptides for two overlooked regions broadens the response and strengthens protection.
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NewsResearchers uncover unexpected twist in fight against antibiotic resistance
A group of Cornell College students and their professor have discovered surprising results in their research on antimicrobial peptides, which are being studied as a method of combating antibiotic resistance.
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NewsResearchers develop new drug to attack an enduring killer
Researchers have developed a new antimalarial drug designed to thwart even the most drug-resistant forms of the infection.
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NewsPromising single-dose malaria treatment advances toward pan-African clinical trial
A promising single-dose malaria treatment that could help address growing drug resistance and simplify treatment for patients.
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NewsHidden genome variation steers growth in fungus-dependent orchid
A chromosome-level genome and population survey of the fungus-dependent orchid Gastrodia elata has revealed how hidden genetic differences may shape growth, tuber form, and carbohydrate allocation.
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NewsReshaping the gut microbiome can boost chemotherapy delivery to tumors
A common antibiotic reshaped gut bacteria in preclinical models, significantly reducing liver clearance and doubling how long chemotherapy remained in circulation to reach tumors.
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NewsScientists fight drug-resistant parasites with nature-inspired drugs
As parasites become increasingly resistant to existing drugs, researchers are working to develop a new generation of treatments for two serious infectious diseases: malaria and babesiosis.
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NewsTwo deadly flowers have big medical potential
Two plants that cause neurotoxicity and paralysis in the tiniest doses are also known to counter pain, malaria, cancer and pests. For the first time, researchers have discovered a way to recreate these powerful compounds in the lab - with the help of yeast.
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NewsTuberculosis drug discovery gets smarter with AI
Scientists have built an artificial intelligence tool to help scientists focus their efforts after initial screening of potential tuberculosis drugs. The team is also using AI to organize years of collaborative data into a searchable form.
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NewsNew antimicrobials could help tackle deadly drug-resistant infections
Scientists have developed a promising new way to create safer and more effective treatments for life-threatening fungal infections. Using genome mining, they identified bacterial species capable of producing new, undiscovered antifungals.
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NewsRemdesivir for COVID-19 linked to better outcomes for adult kidney transplant recipients
Adults with kidney transplants who were treated for COVID-19 with the antiviral remdesivir within a week of diagnosis were less likely than kidney transplant recipients who did not receive the antiviral to experience cardiovascular or kidney problems up to a year later.
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NewsBeyond antibiotics—a paradigm shift toward bacteria-control-centric therapies
A novel extracellular vesicle platform helps polymyxins kill multidrug-resistant gram-negative bacteria at lower and potentially safer doses.
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News A secret weapon against superbugs
A molecular library of potential adjuvants has been used to help restore the activity of vancomycin, a powerful antibiotic widely used to treat serious infections such as MRSA and Clostridium difficile (C. diff).
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NewsResearchers find a new way to tackle drug-resistant infections - starvation
A drug designed to block ECF transporters would attack the bacteria while leaving human cells largely unaffected, substantially reducing the risk of side effects. A research team has succeeded in developing exactly such a drug candidate.
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NewsLast-line antibiotics at risk as children’s resistance rises
Antimicrobial resistance in children is rising globally and will worsen over the next decade, threatening the effectiveness of life‑saving antibiotics, according to a world-first monitoring platform.
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NewsExpanding uses for bioengineered bacterial spores
Fused to the outer layer of bacterial spores, things like enzymes, biosensors, and drugs are easily stored under even extreme conditions.
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NewsNovel antifungal drug shows promise in some patients with Valley Fever
A study found that olorofim, a first-in-class orotomide antifungal agent, showed efficacy in patients with disseminated coccidioidomycosis (DCM), a rare complication of Valley Fever where the fungus spreads from the lungs to other parts of the body.
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NewsROS–Jak2/Stat3 signaling drives HBV-induced liver inflammation
Scientists investigated the mechanisms underlying HBV-induced liver inflammation and identified a reactive oxygen species (ROS)-dependent signaling cascade that activates the Jak2/Stat3 pathway, thereby triggering hepatic inflammatory responses.
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NewsGenetically engineered Bifidobacterium shows potential for oral delivery of cancer vaccines
A novel oral vaccine platform using genetically engineered Bifidobacterium could enhance anti-tumor immunity. In an exploratory phase I clinical study, the vaccine was well tolerated and generated immunologic and clinical findings that warrant further investigation.
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NewsFirst clinical proof of concept for ibuprofen as an adjunctive treatment for tuberculosis
Scientists have published the results of a phase IIa pilot clinical trial assessing ibuprofen as a host-directed therapy in patients with pre-extensively drug-resistant tuberculosis (pre-XDR-TB) and extensively drug-resistant tuberculosis (XDR-TB).