All Pharmaceutical Microbiology articles
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NewsGLP-1s may alleviate depression in mice through the microbiome
Some people taking GLP-1 drugs for diabetes and obesity experience mental health benefits. In a mouse model study, researchers report that these improvements appear to result from gut microbiome changes that lead to an abundance of a microbe strain known to have a favorable effect on neurons related to stress.
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NewsResearchers test two treatments to protect against deadly cattle disease
As cases of a deadly cattle disease rise in Arkansas, researchers are testing two treatments they hope will help ranchers protect their herds. The disease is bovine theileriosis and is caused by the parasite Theileria orientalis Ikeda, carried primarily by the invasive Asian longhorned tick.
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NewsPlants could be used to grow medicines in space, study shows
Astronauts on long space missions may one day use plants to produce fresh stocks of medicines on demand. Researchers developed a simple method to grow and repeatedly harvest plant virus-based pharmaceuticals from plants under space-like conditions, without destroying the plants or generating large amounts of waste.
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NewsFlu drugs show promise against cognitive decline
A class of flu drugs may reduce cognitive decline and premature aging in people living with chronic viral infection. Scientists identified a new biological culprit: the degradation of protective sugar molecules in our bodies, known as glycans, that normally help keep inflammation in check.
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NewsResearchers combine bacteria and viruses to demonstrate a new way to fight cancer
Researchers have designed non-toxic Salmonella bacteria to deliver viruses that are safe to humans but potent against liver and pancreatic cancer tumors. Animal models treated with this combination of bacteria and viruses saw almost all their tumors eliminated and lived significantly longer.
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NewsResearcher investigates how a bioengineered peptide can break through harmful bacterial ‘fortresses’ and curb severe infections
A researcher is refining a powerful therapy for drug-resistant bacteria that pierces the gooey coating that anchors and protects such germs from the drugs we take to kill them. She has found that an antimicrobial peptide naturally found in cows weakens the biofilm defenses of Klebsiella pneumoniae bacteria and destroys it.
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NewsResearchers discover a new antibiotic — and a new way to kill drug-resistant bacteria
Researchers have discovered a new antibiotic that kills some of the world’s most dangerous and drug-resistant bacteria by targeting a previously unknown vulnerability. Manikomycin has shown early effectiveness against priority pathogens including Salmonella, E. coli, and Klebsiella.
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NewsResearcher studying probiotics to fight acid reflux and esophageal cancer
Patients with acid reflux, which occurs when stomach acid pushes up into the esophagus, know the symptoms all too well: heartburn, belching, chest pain and trouble swallowing. Acid reflux also increases the risk of esophageal cancer, but researchers are investigating how a simple probiotic could treat and prevent both conditions.
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NewsResearchers discover how to turn one germ’s drug resistance into an Achilles’ heel
As Mycobacterium tuberculosis mutates to protect itself from rifampicin, it also creates new weak points that other therapies could exploit. A new study shows that the most common rifampicin-resistance mutation slows bacterial RNA polymerase, creating vulnerabilities that future combination therapies may be able to target.
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NewsBiomaterial made from jackfruit latex is a promising treatment for periodontitis
Researchers have developed a biomaterial containing jackfruit latex, pomegranate peel extract, and simvastatin that shows promising efficacy in treating periodontitis. This chronic inflammatory disease of infectious origin leads to the progressive destruction of the tissues supporting the teeth, resulting in bone resorption and loss of attachment.
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NewsStudy identifies serious infection risks linked to targeted cancer therapies
A major real-world study has found serious blood-related side effects associated with antibody-drug conjugates, an increasingly important class of targeted cancer therapies. Some ADCs were associated with substantial rates of severe neutropenia – dangerously low levels of infection-fighting white blood cells – and related complications.
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NewsResearchers evaluate NASA medication storage protocols
Researchers evaluated NASA’s medication handling practices, which currently call for removing medications from their original packaging and storing them in resealable plastic bags. The investigation found that active pharmaceutical ingredients degrade at a higher rate when stored in bags.
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NewsPrecigen presents new long-term durability data for PAPZIMEOS, recently granted seven-year market exclusivity
Precigen, Inc. has announced updated long-term follow-up data from the pivotal study of PAPZIMEOS™ (zopapogene imadenovec-drba) for the treatment of adults with recurrent respiratory papillomatosis (RRP).
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NewsHealth researchers call for support to develop pandemic prevention
The Vanderbilt Center for Antibody Therapeutics has received large-scale government grants and contracts to fund the discovery of human antiviral antibodies. The problem is the next step — finding corporate partners to develop the antibodies through human testing.
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NewsResearchers aim to improve access to high-quality research and biomanufacturing tools in resource-limited settings
Researchers have demonstrated the effectiveness of a suite of low-cost, portable biotechnology tools designed to improve access to laboratory research and diagnostics in resource-limited settings.
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NewsNovel therapeutic drug for tuberculosis is proposed using high-precision molecular simulation
Researchers have proposed a novel therapeutic agent for tuberculosis, using high-precision molecular simulation techniques. The proposed drug is anticipated to bind strongly to the drug-metabolizing enzyme cytochrome P450 (CYP).
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NewsNew antibiotic design could help treat drug-resistant infections
A new study has shown that antibiotics can be chemically redesigned so they are less easily removed by efflux pumps. This allows the antibiotic to remain inside the bacterial cell at higher concentrations, restoring its ability to kill bacteria even when resistance mechanisms are present.
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NewsGenetic engineering of cyanobacteria for the production of sulfated polysaccharide
Researchers have developed a novel strategy to genetically engineer bacteria for the production of sulfated polysaccharides. They demonstrated the successful transfer and functional integration of an entire gene cluster responsible for producing a sulfated polysaccharide known as “synechan.”
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NewsExperimental gene therapy shields brain from toxic protein damage
An experimental gene therapy could help protect the brain from the damage and cognitive decline linked to TDP-43-related proteinopathy, a type of neurodegeneration.
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NewsNew immune system enhancer extends COVID-19 vaccine protection reducing need for repeated boosters
Researchers demonstrated that pairing the original COVID-19 mRNA vaccine with an adjuvant extended the duration of the vaccine’s protection in mice from a few months up to two years. The combo also showed a more pronounced response against omicron viral components than the vaccine alone.