All Pharmaceutical Microbiology articles – Page 2
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NewsNew antibody–drug conjugate strategy to block HIV infection
New antibody–drug conjugates (ADCs) combine a CD4 mimic with neutralizing antibodies for enhanced suppression of HIV infection. By targeting the gp120 on the viral envelope via a two-step mechanism, the ADCs effectively block viral entry.
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NewsA yeast enzyme helps human cells overcome mitochondrial defects
An international team has experimentally uncoupled nucleotide synthesis from mitochondrial activity using ScURA, a yeast-derived genetic tool now available to the research community that will enable new explorations of cellular metabolism.
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NewsRhododendron-derived drugs now made by bacteria
Bioengineered E. coli bacteria can now produce a group of compounds with anticancer, anti-HIV, antidiabetic and anti-inflammatory activities. The compounds, orsellinic acid-derived meroterpenoids, are produced by Rhododendron species.
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NewsImmunity against common virus leveraged against pancreatic cancer
Researchers have discovered a promising new treatment approach for pancreatic cancer. The approach leverages the body’s natural immune response to cytomegalovirus (CMV), a common but typically harmless virus that most people are infected with at some point in their lives.
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NewsHIV antibody opens up new approaches for vaccine development and combination therapies
An international research team has identified a novel HIV antibody that targets the virus at a particularly vulnerable site and overcomes previous limitations of known antibodies. The study opens up new perspectives for the development of vaccines and therapeutics against HIV-1.
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NewsBasic research on Listeria bacteria leads to unique cancer therapy
After nearly 40 years of research on how After nearly 40 years of research on how Listeria bacteria manipulate our cells and battle our immune system to cause listeriosis, researchers have discovered a way to turn the bacteria into a potent booster of the immune system — and a potential weapon against cancer.
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NewsResearchers develop new inhalable treatment for TB
Researchers have developed an inhalable, immunomodulating, biocompatible nanoparticle system encapsulating rifampin, one of the most important TB drugs.
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NewsVirus-based therapy boosts anti-cancer immune responses to brain cancer
A study has shown that a single injection of an oncolytic virus—a genetically modified virus that selectively infects and destroys cancer cells—can recruit immune cells to penetrate and persist deep within brain tumors.
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NewsShorter treatment regimens are safe options for preventing active tuberculosis
A study comparing one- and three-month antibiotic treatments to prevent active tuberculosis (TB) finds that a high percentage of patients successfully completed both regimens and suffered few adverse side effects.
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NewsGenotype-specific response to 144-week entecavir therapy for HBeAg-positive chronic hepatitis B
HBV genotype B demonstrates superior histological responses to ETV therapy compared with genotype C, supporting the clinical value of HBV genotyping for personalized CHB management. These findings highlight the importance of considering viral genotype when evaluating treatment outcomes.
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NewsEthris and German Center for Infection Research (DZIF) announce strategic collaboration to develop mRNA-based vaccines
Ethris GmbH, a clinical-stage biotechnology company pioneering next-generation RNA therapeutics and vaccines, and the German Center for Infection Research (DZIF), have announced a strategic research collaboration to develop mRNA-based vaccines for the prevention and treatment of infectious diseases.
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NewsResearchers on the cusp of a vaccine for a global health threat
Researchers are on the cusp of a new vaccine to prevent chikungunya, a global health threat which attacks human joint tissue. The team tested whether they could engineer E. coli to assemble biopolymer particles which displayed chikungunya antigens and performed as a vaccine.
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NewsDiscovery of SARS-CoV-2 PLpro inhibitors and RIPK1 inhibitors with synergistic antiviral efficacy in a mouse COVID-19 model
A new article publication discusses the discovery of SARS-CoV-2 PLpro inhibitors and RIPK1 inhibitors with synergistic antiviral efficacy in a mouse COVID-19 model.
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New vaccine platform promotes rare protective B cells
Based on a virus-like particle built with a DNA scaffold, the approach could generate broadly neutralizing antibody responses against HIV or influenza.
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NewsGreen chemistry: Friendly bacteria can unlock hidden metabolic pathways in plant cell cultures
Co-culturing plant cells with harmless bacteria can expand the diversity of obtainable plant-derived compounds for pharmaceuticals, cosmetics, and agrochemicals, a new study shows.
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NewsScientists demonstrate first-ever single-shot HIV vaccine neutralization success
Scientists have developed an HIV vaccine candidate that achieves something never before observed in the field: inducing neutralizing antibodies against HIV after a single immunization in nonhuman primates.
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NewsLaunch of clinical trial of investigative nasal spray medicine to prevent illnesses from respiratory viruses
A new clinical trial will test a new experimental intranasal spray designed to boost immune defenses and reduce illness from respiratory viruses.
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NewsResearchers enable microorganisms to build molecules with light
Researchers are continually looking for new ways to hack the cellular machinery of microbes to make useful products. A new study shows they can expand the biosynthetic capabilities of these microbes by using light to help access new types of chemical transformations.
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NewsSynthetic compound has the potential to treat malaria and prevent its transmission
Tests on cell cultures and rodents have shown that the new molecule acts on all three stages of the disease cycle, eliminating the parasite from human blood and liver and preventing transmission to mosquitoes.
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NewsNatural sunscreen compounds show potential to support skin health and blood pressure
Researchers have discovered that natural ‘sunscreen’ compounds found in algae and cyanobacteria may also support skin and heart health.